Since the end of 2019,COVID-19 has caused worldwide pandemic.SARS-CoV-2,the culprit of this epidemic,binds to the host receptor Angiotensin converting enzyme 2(ACE2)using spike(S)protein for cell entry.Recent studies ...Since the end of 2019,COVID-19 has caused worldwide pandemic.SARS-CoV-2,the culprit of this epidemic,binds to the host receptor Angiotensin converting enzyme 2(ACE2)using spike(S)protein for cell entry.Recent studies showed that ACE2 expressed at a low level in the main target organs such as lung and bronchial tissues.How SARS-CoV-2 efficiently invades into the respiratory system or other organs with low levels of ACE2 is an urgent problem to be solved.展开更多
Gene selection is an indispensable step for analyzing noisy and high-dimensional single-cell RNA-seq(scRNA-seq)data.Compared with the commonly used variance-based methods,by mimicking the human maker selection in the ...Gene selection is an indispensable step for analyzing noisy and high-dimensional single-cell RNA-seq(scRNA-seq)data.Compared with the commonly used variance-based methods,by mimicking the human maker selection in the 2D visualization of cells,a new feature selection method called HRG(Highly Regional Genes)is proposed to find the informative genes,which show regional expression patterns in the cell-cell similarity network.We mathematically find the optimal expression patterns that can maximize the proposed scoring function.In comparison with several unsupervised methods,HRG shows high accuracy and robustness,and can increase the performance of downstream cell clustering and gene correlation analysis.Also,it is applicable for selecting informative genes of sequencing-based spatial transcriptomic data.展开更多
基金supported by Clinical Research Cultivation Project of First Affiliated Hospital of Nanchang University(China)(No.YFYLCYJPY202001).
文摘Since the end of 2019,COVID-19 has caused worldwide pandemic.SARS-CoV-2,the culprit of this epidemic,binds to the host receptor Angiotensin converting enzyme 2(ACE2)using spike(S)protein for cell entry.Recent studies showed that ACE2 expressed at a low level in the main target organs such as lung and bronchial tissues.How SARS-CoV-2 efficiently invades into the respiratory system or other organs with low levels of ACE2 is an urgent problem to be solved.
基金supported by the National Key Research and Development Program(2020YFA0712403,2020YFA0906900)National Natural Science Foundation of China(61922047,81890993,61721003,62133006)BNRIST Young Innovation Fund(BNR2020RC01009)。
文摘Gene selection is an indispensable step for analyzing noisy and high-dimensional single-cell RNA-seq(scRNA-seq)data.Compared with the commonly used variance-based methods,by mimicking the human maker selection in the 2D visualization of cells,a new feature selection method called HRG(Highly Regional Genes)is proposed to find the informative genes,which show regional expression patterns in the cell-cell similarity network.We mathematically find the optimal expression patterns that can maximize the proposed scoring function.In comparison with several unsupervised methods,HRG shows high accuracy and robustness,and can increase the performance of downstream cell clustering and gene correlation analysis.Also,it is applicable for selecting informative genes of sequencing-based spatial transcriptomic data.
