The complement system,a key component of innate immunity,is a first-line defender against foreign pathogens such as HIV-1.The role of the complement system in HIV-1 pathogenesis appears to be multifaceted.Although the...The complement system,a key component of innate immunity,is a first-line defender against foreign pathogens such as HIV-1.The role of the complement system in HIV-1 pathogenesis appears to be multifaceted.Although the complement system plays critical roles in clearing and neutralizing HIV-1 virions,it also represents a critical factor for the spread and maintenance of the virus in the infected host.In addition,complement regulators such as human CD59 present in the envelope of HIV-1 prevent complement-mediated lysis of HIV-1.Some novel approaches are proposed to combat HIV-1 infection through the enhancement of antibody-dependent complement activity against HIV-1.In this paper,we will review these diverse roles of complement in HIV-1 infection.展开更多
文摘The complement system,a key component of innate immunity,is a first-line defender against foreign pathogens such as HIV-1.The role of the complement system in HIV-1 pathogenesis appears to be multifaceted.Although the complement system plays critical roles in clearing and neutralizing HIV-1 virions,it also represents a critical factor for the spread and maintenance of the virus in the infected host.In addition,complement regulators such as human CD59 present in the envelope of HIV-1 prevent complement-mediated lysis of HIV-1.Some novel approaches are proposed to combat HIV-1 infection through the enhancement of antibody-dependent complement activity against HIV-1.In this paper,we will review these diverse roles of complement in HIV-1 infection.
