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抗IgLON5抗体脑炎1例报告
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作者 李才明 徐均洋 +4 位作者 郑燕霞 陈绮莉 吴楚妍 邱志维 黄文城 《阿尔茨海默病及相关病杂志》 2023年第1期12-14,共3页
目的:分析抗IgLON5抗体相关脑炎的临床特征、发病机制、诊断及治疗,以提高临床医师对该疾病的认识。方法:收集1例抗IgLON5抗体相关脑炎患者的临床表现、影像学、免疫抗体、基因检测结果等资料,结合文献进行复习。结果:患者男性,61岁,主... 目的:分析抗IgLON5抗体相关脑炎的临床特征、发病机制、诊断及治疗,以提高临床医师对该疾病的认识。方法:收集1例抗IgLON5抗体相关脑炎患者的临床表现、影像学、免疫抗体、基因检测结果等资料,结合文献进行复习。结果:患者男性,61岁,主要临床表现为认知障碍、睡眠障碍、球麻痹和癫痫,脑脊液抗IgLON5抗体IgG阳性(1:100),血清抗IgLON5抗体IgG阳性(1:300),基因检测HLA单倍型HLA-DQB1*05:01-DRB1*10:01。入院后予激素冲击治疗、丙戊酸抗癫痫,症状明显改善。结论:本文报道1例以认知障碍、睡眠障碍、球麻痹和癫痫为主要表现抗IgLON5抗体相关脑炎,对激素治疗有反应。 展开更多
关键词 抗IgLON5抗体脑炎 激素治疗 自身免疫病
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Road Safety Performance Function Analysis With Visual Feature Importance of Deep Neural Nets 被引量:1
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作者 Guangyuan Pan Liping Fu +2 位作者 qili chen Ming Yu Matthew Muresan 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2020年第3期735-744,共10页
Road safety performance function(SPF) analysis using data-driven and nonparametric methods, especially recent developed deep learning approaches, has gained increasing achievements. However, due to the learning mechan... Road safety performance function(SPF) analysis using data-driven and nonparametric methods, especially recent developed deep learning approaches, has gained increasing achievements. However, due to the learning mechanisms are hidden in a"black box" in deep learning, traffic features extraction and intelligent importance analysis are still unsolved and hard to generate.This paper focuses on this problem using a deciphered version of deep neural networks(DNN), one of the most popular deep learning models. This approach builds on visualization, feature importance and sensitivity analysis, can evaluate the contributions of input variables on model's "black box" feature learning process and output decision. Firstly, a visual feature importance(Vi FI) method that describes the importance of input features is proposed by adopting diagram and numerical-analysis. Secondly,by observing the change of weights using Vi FI on unsupervised training and fine-tuning of DNN, the final contributions of input features are calculated according to importance equations for both steps that we proposed. Sequentially, a case study based on a road SPF analysis is demonstrated, using data collected from a major Canadian highway, Highway 401. The proposed method allows effective deciphering of the model's inner workings and allows the significant features to be identified and the bad features to be eliminated. Finally, the revised dataset is used in crash modeling and vehicle collision prediction, and the testing result verifies that the deciphered and revised model achieves state-of-theart performance. 展开更多
关键词 DEEP learning DEEP NEURAL network(DNN) feature IMPORTANCE ROAD safety PERFORMANCE function
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Detection and Prevention of Environmental Hormone 被引量:1
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作者 qili chen Ling Pan +4 位作者 Yanhong Xv Xuan Fu Hongzhen Sun Hongyan Li Pingping Liu 《Meteorological and Environmental Research》 CAS 2013年第12期61-62,共2页
The sorts and detection methods of environmental hormone were analyzed firstly,and then the effects of environmental hormone on organisms and humanity were discussed. Finally the control measures of environmental horm... The sorts and detection methods of environmental hormone were analyzed firstly,and then the effects of environmental hormone on organisms and humanity were discussed. Finally the control measures of environmental hormone pollution,such as reducing the use of goods and pesticide and the study of new substitutes and degradation technology are advanced. 展开更多
关键词 Environmental hormone Environmental pollution Exogenous compound China
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