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Intrinsic fluctuation and susceptibility in somatic cell reprogramming process
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作者 沈健 张小敏 +3 位作者 李齐亮 王歆宇 赵蕴杰 贾亚 《Chinese Physics B》 SCIE EI CAS CSCD 2019年第4期113-120,共8页
Based on the coherent feedforward transcription regulation loops in somatic cell reprogramming process, a stochastic kinetic model is proposed to study the intrinsic fluctuations in the somatic cell reprogramming. The... Based on the coherent feedforward transcription regulation loops in somatic cell reprogramming process, a stochastic kinetic model is proposed to study the intrinsic fluctuations in the somatic cell reprogramming. The Fano factor formulas of key genes expression level in the coherent feedforward transcription regulation loops are derived by using of Langevin theory. It is found that the internal fluctuations of gene expression levels mainly depend on itself activation ratio and degradation ratio. When the self-activation ratio(or self-degradation ratio) is increased, the Fano factor increases reaches a maximum and then decreases. The susceptibility is used to measure the sensitivity of steady-state response to the variation in systemic parameters. It is found that with the increase of the self-activation ratio(or self-degradation ratio), the susceptibility of steady-state increases at first, it reaches a maximum, and it then decreases. The magnitude of the maximum is increased with the increase of activated ratio by the upstream transcription factor. 展开更多
关键词 INTRINSIC FLUCTUATION SUSCEPTIBILITY coherent feedforward LOOPS SOMATIC cell REPROGRAMMING
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Sent2Agri System Based Crop Type Mapping in Yellow River Irrigation Area 被引量:2
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作者 Jinlong FAN Pierre DEFOURNY +7 位作者 Qinghan DONG Xiaoyu ZHANG Mathilde De VROEY Nicolas BELLEMANS Qi XU qiliang li Lei ZHANG Hao GAO 《Journal of Geodesy and Geoinformation Science》 2020年第4期110-117,共8页
Agricultural monitoring is essential for adequate management of food production and distribution.Crop land and crop type classification,using remote sensing time series,form an important tool to capture the agricultur... Agricultural monitoring is essential for adequate management of food production and distribution.Crop land and crop type classification,using remote sensing time series,form an important tool to capture the agricultural production information.The recently launched Sentinel-2 satellites provide unprecedented monitoring capacities in terms of spatial resolution,swath width,and revisit frequency.The Sentinel-2 for Agriculture(Sen2-Agri)system has been developed to fully exploit those capacities,by providing four relevant earth observation products for agricultural monitoring.Under the Dragon 4 Program,the crop mapping with various satellite images and a specific focus on the Yellow River irrigated agricultural area in the Ningxia Hui Autonomous Region in China was carried out with the Sentinel-2 for Agriculture system(Sent2Agri).9 types of crops were classified and the crop type map in 2017 was produced based on 35 scenes Sentinel 2A/B images.The overall accuracy computed from the error confusion matrix is 88%,which includes the cropped and uncropped types.After the removal of the uncropped area,the overall accuracy for a cropped decrease to 73%.In order to further improve the crop classification accuracy,the training dataset should be further improved and tuned. 展开更多
关键词 crop mapping Dragon Program Sentinel 2 Sent2Agri system
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Pediatric reference intervals in China(PRINCE):design and rationale for a large,multicenter collaborative cross-sectional study 被引量:13
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作者 Xin Ni Wenqi Song +25 位作者 Xiaoxia Peng Ying Shen Yaguang Peng qiliang li Yan Wang lixin Hu Yanying Cai Hong Shang Min Zhao Hong Jiang Yaoguo Huang Runqing Mu Wenxiang Chen Mingting Peng Chuanbao Zhang Jie Zeng Chenbin li Hongling Yang Yongmei Jiang Jin Xu Guixia li Hongbing Chen Yun Xiang Sancheng Cao Zhenxin Guo Dapeng Chen 《Science Bulletin》 SCIE EI CAS CSCD 2018年第24期1626-1634,共9页
There is a lack of accurate pediatric reference intervals(RIs) in China, with most commonly used RIs established without consideration of the effect of age and gender. The Pediatric Reference Intervals in China(PRINCE... There is a lack of accurate pediatric reference intervals(RIs) in China, with most commonly used RIs established without consideration of the effect of age and gender. The Pediatric Reference Intervals in China(PRINCE) project aims to establish and verify pediatric RIs for 31 common laboratory measurands.The project will be a large, multicenter cross-sectional study:14,490 healthy children and adolescents aged up to 19 years will be surveyed by 10 children's hospitals and one pediatric department of a university hospital. To evaluate the feasibility and efficiency of the study methods, 602 children were surveyed in the pilot phase of the PRINCE study in April 2017: it found that some measurands were distinctly age dependent and that there were differences between values for males and females. The results of the pilot study affirmed the necessity of the PRINCE project for Chinese pediatrics. The pilot also indicated potential difficulties in the full survey, e.g., difficulties in recruiting children aged under 3 years and insufficient collection of blood samples from infants. The operation of the PRINCE project has been modified based on the findings in the pilot study toward improving the validity of the PRINCE project and promoting its openness and transparency. 展开更多
关键词 Reference INTERVAL PEDIATRIC China CROSS-SECTIONAL study
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Controlled manipulation of conductive ferroelectric domain walls and nanoscale domains in BiFeO_(3) thin films 被引量:1
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作者 Dongfeng Zheng Guo Tian +9 位作者 Yadong Wang Wenda Yang Luyong Zhang Zoufei Chen Zhen Fan Deyang Chen Zhipeng Hou Xingsen Gao qiliang li Jun-Ming liu 《Journal of Materiomics》 SCIE 2022年第2期274-280,共7页
Recently,there is a surge of research interest in configurable ferroelectric conductive domain walls which have been considered as possible fundamental building blocks for future electronic devices.In this work,by usi... Recently,there is a surge of research interest in configurable ferroelectric conductive domain walls which have been considered as possible fundamental building blocks for future electronic devices.In this work,by using piezoresponse force microscopy and conductive atomic force microscopy,we demonstrated the controlled manipulation of various conductive domain walls in epitaxial BiFeO_(3) thin films,e.g.neutral domain walls(NDW)and charged domain walls(CDWs).More interestingly,a specific type of nanoscale domains was also identified,which are surrounded by highly conductive circular CWDs.Similar nano-scale domains can also be controlled created and erasured by applying local field via conductive probe,which allow nondestructive current readout of different domain states with a large on/off resistance ratio up to 102.The results indicate the potential to design and develop high-density non-volatile ferroelectric memories by utilizing these programable conductive nanoscale domain walls. 展开更多
关键词 BiFeO_(3)thin film Conductive domain wall Nanoscale domain High density memory
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