When COVID-19 pandemic hit China,Chinese clinical psychologists,counselors and other practitioners reacted quickly to provide psychological interventions for different target groups.Different professional ethical conc...When COVID-19 pandemic hit China,Chinese clinical psychologists,counselors and other practitioners reacted quickly to provide psychological interventions for different target groups.Different professional ethical concerns and potential transgressions arose during different stages of pandemic.This paper aimed to summarize different ethical concerns and transgressions during different stages of pandemic in China,as well as how the professional ethical workgroup in the registration system of clinical psychologists and professional organizations of Chinese Psychological Society(CPS)to publish a series of documents as recommendations on ethical practice.It is hoped by providing a picture of“problems vs.solutions”in terms of professional ethical issues on psychological interventions for COVID-19 pandemic in China,the paper may provide certain inspirations as well as emotional support to clinical practitioners from other countries and regions who have beenfighting the pandemic.展开更多
Circulating cell-free DNAs(cfDNAs)are fragmented DNA molecules released into the blood by cells.Previous studies have suggested that mitochondria-originated cfDNA fragments(mt-cfDNAs)in cancer patients are more fragme...Circulating cell-free DNAs(cfDNAs)are fragmented DNA molecules released into the blood by cells.Previous studies have suggested that mitochondria-originated cfDNA fragments(mt-cfDNAs)in cancer patients are more fragmented than those from healthy controls.However,it is still unknown where these short mtcfDNAs originate,and whether the length of mt-cfDNAs can be correlated with tumor burden and cancer progression.In this study,we first performed whole-genome sequencing analysis(WGS)of cfDNAs from a human tumor cell line-xenotransplantation mouse model and found that mt-cfDNAs released from transplanted tumor cells were shorter than the mouse counterpart.We next analyzed blood cfDNA samples from hepatocellular carcinoma and prostate cancer patients and found that mt-cfDNA lengths were inversely related to tumor size as well as the concentration of circulating tumor DNA.Our study suggested that monitoring the size of mt-cfDNAs in cancer patients would be a useful way to estimate tumor burden and cancer progression.展开更多
Drug efficiency delivery and release to target site play an important role in the treatment of cancer. To achieve these goals, developing drug delivery systems is the key step. The common materials used for drug deliv...Drug efficiency delivery and release to target site play an important role in the treatment of cancer. To achieve these goals, developing drug delivery systems is the key step. The common materials used for drug delivery like liposomes, micelles, dendrimers cannot control the delivery and releasing by spatial and temporal. In this paper, we design a photoresponsive drug delivery system to reduce the side effects of traditional chemotherapy on normal cells and improve therapeutic efficacy in treating cancers. We synthesized two kinds of photo-responsive polymers using two different monomers containing two photoresponsive groups. The two monomers were crosslinked by poly （ethylene glycol） dimethacrylate to form polymers and then encapsulated β-lapachone into the nanoparticles, after UV irradiation, the particle will degrade and release the drug. This method may provide new strategies for the photoresponsive nanomaterials.展开更多
文摘When COVID-19 pandemic hit China,Chinese clinical psychologists,counselors and other practitioners reacted quickly to provide psychological interventions for different target groups.Different professional ethical concerns and potential transgressions arose during different stages of pandemic.This paper aimed to summarize different ethical concerns and transgressions during different stages of pandemic in China,as well as how the professional ethical workgroup in the registration system of clinical psychologists and professional organizations of Chinese Psychological Society(CPS)to publish a series of documents as recommendations on ethical practice.It is hoped by providing a picture of“problems vs.solutions”in terms of professional ethical issues on psychological interventions for COVID-19 pandemic in China,the paper may provide certain inspirations as well as emotional support to clinical practitioners from other countries and regions who have beenfighting the pandemic.
基金We would like to thank Dr.Anthony E.Sisk Jr.at UCLA Genitourinary Pathology Unit for histological analysis.This study is funded by National Institutes of Health(Grant No:RO1 DE DE025474,P50CA092131,and P50CA211015),and CIRM Stem Cell Genomics Centers of Excellence Award.
文摘Circulating cell-free DNAs(cfDNAs)are fragmented DNA molecules released into the blood by cells.Previous studies have suggested that mitochondria-originated cfDNA fragments(mt-cfDNAs)in cancer patients are more fragmented than those from healthy controls.However,it is still unknown where these short mtcfDNAs originate,and whether the length of mt-cfDNAs can be correlated with tumor burden and cancer progression.In this study,we first performed whole-genome sequencing analysis(WGS)of cfDNAs from a human tumor cell line-xenotransplantation mouse model and found that mt-cfDNAs released from transplanted tumor cells were shorter than the mouse counterpart.We next analyzed blood cfDNA samples from hepatocellular carcinoma and prostate cancer patients and found that mt-cfDNA lengths were inversely related to tumor size as well as the concentration of circulating tumor DNA.Our study suggested that monitoring the size of mt-cfDNAs in cancer patients would be a useful way to estimate tumor burden and cancer progression.
文摘Drug efficiency delivery and release to target site play an important role in the treatment of cancer. To achieve these goals, developing drug delivery systems is the key step. The common materials used for drug delivery like liposomes, micelles, dendrimers cannot control the delivery and releasing by spatial and temporal. In this paper, we design a photoresponsive drug delivery system to reduce the side effects of traditional chemotherapy on normal cells and improve therapeutic efficacy in treating cancers. We synthesized two kinds of photo-responsive polymers using two different monomers containing two photoresponsive groups. The two monomers were crosslinked by poly （ethylene glycol） dimethacrylate to form polymers and then encapsulated β-lapachone into the nanoparticles, after UV irradiation, the particle will degrade and release the drug. This method may provide new strategies for the photoresponsive nanomaterials.
