Multiple endocrine neoplasia type 2A （MEN2A）, a subtype of MEN2, is characterized by medullary thyroid cancer, pheochromocytoma, and primary hyperparathyroidism. A Han Chinese pedigree with MEN2A was investigated fo...Multiple endocrine neoplasia type 2A （MEN2A）, a subtype of MEN2, is characterized by medullary thyroid cancer, pheochromocytoma, and primary hyperparathyroidism. A Han Chinese pedigree with MEN2A was investigated following confirmation of the proband＇s diagnosis by pathological findings and DNA/biochemical screening. DNA samples from 4 other family members were collected and exon 5, 8, 10, 11, 13, 16 and 18 of the RET proto-oncogene were sequenced and then analyzed. A missense mutation of TGG （Trp） to TGC （Cys） at codon 634 （the classic MEN2A mutation） in exon 11 of the RET gene was detected in 3 family members, including the proband. Sequencing data were compared with the human gene mutation database. Elevated serum calcitonin level was detected initially; medullary thyroid carcinoma was revealed in the 3 cases and adrenal pheochromocytoma was also found in the proband. Elective operations were successfully performed on the adrenal and thyroid glands because of pheochromocytoma and medullary thyroid carcinoma. Our case study confirms that integrated DNA-based/biochemical screening is crucial for early diagnosis of MEN2A and is helpful in the screening of their relatives. In addition, DNA-based screening may occasionally uncover a previously unknown RET sequence.展开更多
We experimentally demonstrate that,based on operational condition optimization,a common quantum well (QW) semiconductor optical amplifier (SOA) has the ability of amplitude regeneration for return-to-zero (RZ) differe...We experimentally demonstrate that,based on operational condition optimization,a common quantum well (QW) semiconductor optical amplifier (SOA) has the ability of amplitude regeneration for return-to-zero (RZ) differential phase shift keying (DPSK) signals.For a single-channel RZ-DPSK regeneration scheme,a significant eye-opening enhancement and a negative power penalty of about 1.0 dB are obtained.For dual-channel RZ-DPSK regeneration,it can also be found that the eye-opening improvement and power penalty decrease in each channel.In addition,the DPSK regeneration scheme based on a single QW SOA is quite simple and stable.展开更多
We experimentally demonstrate single and multicasting inverted wavelength conversion at 80 Gb/s by using the cross-gain modulation and cross-phase modulation in a single semiconductor optical amplifier(SOA).In all the...We experimentally demonstrate single and multicasting inverted wavelength conversion at 80 Gb/s by using the cross-gain modulation and cross-phase modulation in a single semiconductor optical amplifier(SOA).In all the cases,converted signals with a high extinction ratio(ER)and large eye opening are obtained.For singlechannel wavelength conversion,the ER of the output signal is as high as 30.10 dB.For three-channel wavelength multicasting,high quality converted signals could also be observed.The ERs with three channels are 21.54 dB,18.58 dB and 17.72 dB,respectively.Thus,one-and three-channel wavelength conversion with high performance can be achieved by using a single quantum-well SOA.展开更多
基金supported by grant 81170747 from the National Natural Sciences Foundation of Chinagrant H201106 from Health Promotion Foundation of Jiangsu Provincegrant from the Office of Human Resources and Social Security of Jiangsu Province (Peak of the Six Personnel in Jiangsu Province) to Hongwen Zhou
文摘Multiple endocrine neoplasia type 2A （MEN2A）, a subtype of MEN2, is characterized by medullary thyroid cancer, pheochromocytoma, and primary hyperparathyroidism. A Han Chinese pedigree with MEN2A was investigated following confirmation of the proband＇s diagnosis by pathological findings and DNA/biochemical screening. DNA samples from 4 other family members were collected and exon 5, 8, 10, 11, 13, 16 and 18 of the RET proto-oncogene were sequenced and then analyzed. A missense mutation of TGG （Trp） to TGC （Cys） at codon 634 （the classic MEN2A mutation） in exon 11 of the RET gene was detected in 3 family members, including the proband. Sequencing data were compared with the human gene mutation database. Elevated serum calcitonin level was detected initially; medullary thyroid carcinoma was revealed in the 3 cases and adrenal pheochromocytoma was also found in the proband. Elective operations were successfully performed on the adrenal and thyroid glands because of pheochromocytoma and medullary thyroid carcinoma. Our case study confirms that integrated DNA-based/biochemical screening is crucial for early diagnosis of MEN2A and is helpful in the screening of their relatives. In addition, DNA-based screening may occasionally uncover a previously unknown RET sequence.
基金Supported in part by the National Natural Science Foundation of China under Grant No 61007042the Doctoral Program Foundation of Institutions of Higher Education of China(20090142110052)the National Basic Research Program of China under Grant No 2011CB301704.
文摘We experimentally demonstrate that,based on operational condition optimization,a common quantum well (QW) semiconductor optical amplifier (SOA) has the ability of amplitude regeneration for return-to-zero (RZ) differential phase shift keying (DPSK) signals.For a single-channel RZ-DPSK regeneration scheme,a significant eye-opening enhancement and a negative power penalty of about 1.0 dB are obtained.For dual-channel RZ-DPSK regeneration,it can also be found that the eye-opening improvement and power penalty decrease in each channel.In addition,the DPSK regeneration scheme based on a single QW SOA is quite simple and stable.
基金by the National Natural Science Foundation of China under Grant No 61007042the Doctoral Program Foundation of Institutions of Higher Education of China(20090142110052)the National Basic Research Program of China under Grant No 2011CB301704。
文摘We experimentally demonstrate single and multicasting inverted wavelength conversion at 80 Gb/s by using the cross-gain modulation and cross-phase modulation in a single semiconductor optical amplifier(SOA).In all the cases,converted signals with a high extinction ratio(ER)and large eye opening are obtained.For singlechannel wavelength conversion,the ER of the output signal is as high as 30.10 dB.For three-channel wavelength multicasting,high quality converted signals could also be observed.The ERs with three channels are 21.54 dB,18.58 dB and 17.72 dB,respectively.Thus,one-and three-channel wavelength conversion with high performance can be achieved by using a single quantum-well SOA.
