Objective: To investigate the correlation of serum pepsinogen Ⅰ/Ⅱ ratio and gastrin-17 content with malignant proliferation of cancer cells in patients with gastric cancer. Methods:Superficial gastritis group (n=247...Objective: To investigate the correlation of serum pepsinogen Ⅰ/Ⅱ ratio and gastrin-17 content with malignant proliferation of cancer cells in patients with gastric cancer. Methods:Superficial gastritis group (n=247), gastric ulcer group (n=159) and gastric cancer group (n=97) who were pathologically diagnosed by gastroscopy in Chongqing wanzhou district people's hospital of 5 between August 2016 and August 2017 were selected, and the differences in serum pepsinogen Ⅰ/Ⅱ ratio and gastrin-17 content as well as proliferation and apoptosis gene expression in lesion tissue were compared among the three groups. Pearson test was used to evaluate the correlation of pepsinogen Ⅰ/Ⅱ ratio and gastrin-17 content with malignant proliferation activity of cancer cells in patients with gastric cancer. Results: Serum pepsinogenⅠ/Ⅱ ratio and gastrin-17 content in gastric cancer group were lower than those in gastric ulcer group and superficial gastritis group. Proliferation genes EIF5A2, MACF1 and PIK3CD mRNA expression levels in gastric cancer group were higher than those in gastric ulcer group and superficial gastritis group whereas SIRT1 mRNA expression level was lower than that in gastric ulcer group and superficial gastritis group;apoptosis gene Livin mRNA expression level was higher than that in gastric ulcer group and superficial gastritis group whereas Bad and Noxa mRNA expression levels were lower than those in gastric ulcer group and superficial gastritis group;serum pepsinogen Ⅰ/Ⅱ ratio and gastrin-17 content in gastric cancer group were negatively correlated with EIF5A2, MACF1, PIK3CD and Livin mRNA expression levels, and positively correlated with SIRT1, Bad and Noxa mRNA expression levels. Conclusion: The serum pepsinogen Ⅰ/Ⅱ ratio and gastrin-17 content abnormally reduce in patients with gastric cancer, and the specific levels are directly correlated with gastric cancer cell proliferation and apoptosis activity.展开更多
Corrosion at the taper/trunnion interface of total hip replacement(THR)often results in severe complications.However,the underlying mechanisms of biotribocorrosion at the taper/trunnion interface during the long-term ...Corrosion at the taper/trunnion interface of total hip replacement(THR)often results in severe complications.However,the underlying mechanisms of biotribocorrosion at the taper/trunnion interface during the long-term walking gait cycles remain to be fully understood.In this study,a hip joint simulator was therefore instrumented with an electrochemical cell for in-situ monitoring of the tribocorrosion evolution in a metal-on-polyethylene(MoP)THR during a typical long-term walking gait.In addition,the biotribocorrosion mechanism was investigated via surface and chemical characterizations.The experimental results confirmed that the taper/trunnion interface dominated the contemporary MoP hip joint corrosion.Three cyclic variations in the open circuit potential(OCP)were observed throughout the long-term electrochemical measurements,attributed to the formation and disruption of the adsorbed protein layer.The corrosion exhibited an initial increase at each period,peaking at approximately 0.125 million cycles,followed by a subsequent gradual reduction.Surface and chemical analyses revealed the formation of a tribochemical reaction layer(tribolayer)on the worn surface of the taper/trunnion interface.The surface/chemical characterizations and the electrochemical measurements indicated that the adhesion force of the adsorbed protein layer was weaker than that of the tribolayer.In contrast,the opposite was true for the corrosion resistance.Based on the observations from this study,the tribocorrosion mechanism of the taper/trunnion interface under the long-term walking gait cycles is deduced.展开更多
The destruction of a regular black hole event horizon might provide us the possibility to access regions inside black hole event horizon.This paper investigates the possibility of overcharging a charged Taub-NUT regul...The destruction of a regular black hole event horizon might provide us the possibility to access regions inside black hole event horizon.This paper investigates the possibility of overcharging a charged Taub-NUT regular black hole via the scattering of a charged field and the absorption of a charged particle.For the charged scalar field scattering,both the near-extremal and extremal charged Taub-NUT regular black holes cannot be overcharged.For the test charged particle absorption,the result shows that the event horizon of the extremal charged Taub-NUT regular black hole still exists while the event horizon of the near-extremal one can be destroyed.However,if the charge and energy cross the event horizon in a continuous path,the near-extremal charged Taub-NUT regular black hole might not be overcharged.展开更多
文摘Objective: To investigate the correlation of serum pepsinogen Ⅰ/Ⅱ ratio and gastrin-17 content with malignant proliferation of cancer cells in patients with gastric cancer. Methods:Superficial gastritis group (n=247), gastric ulcer group (n=159) and gastric cancer group (n=97) who were pathologically diagnosed by gastroscopy in Chongqing wanzhou district people's hospital of 5 between August 2016 and August 2017 were selected, and the differences in serum pepsinogen Ⅰ/Ⅱ ratio and gastrin-17 content as well as proliferation and apoptosis gene expression in lesion tissue were compared among the three groups. Pearson test was used to evaluate the correlation of pepsinogen Ⅰ/Ⅱ ratio and gastrin-17 content with malignant proliferation activity of cancer cells in patients with gastric cancer. Results: Serum pepsinogenⅠ/Ⅱ ratio and gastrin-17 content in gastric cancer group were lower than those in gastric ulcer group and superficial gastritis group. Proliferation genes EIF5A2, MACF1 and PIK3CD mRNA expression levels in gastric cancer group were higher than those in gastric ulcer group and superficial gastritis group whereas SIRT1 mRNA expression level was lower than that in gastric ulcer group and superficial gastritis group;apoptosis gene Livin mRNA expression level was higher than that in gastric ulcer group and superficial gastritis group whereas Bad and Noxa mRNA expression levels were lower than those in gastric ulcer group and superficial gastritis group;serum pepsinogen Ⅰ/Ⅱ ratio and gastrin-17 content in gastric cancer group were negatively correlated with EIF5A2, MACF1, PIK3CD and Livin mRNA expression levels, and positively correlated with SIRT1, Bad and Noxa mRNA expression levels. Conclusion: The serum pepsinogen Ⅰ/Ⅱ ratio and gastrin-17 content abnormally reduce in patients with gastric cancer, and the specific levels are directly correlated with gastric cancer cell proliferation and apoptosis activity.
基金supported by the National Natural Science Foundation of China(52035012)the Science and Technology Planning Project of Sichuan Province(2020YJ0032)the 111 Project(B20008).
文摘Corrosion at the taper/trunnion interface of total hip replacement(THR)often results in severe complications.However,the underlying mechanisms of biotribocorrosion at the taper/trunnion interface during the long-term walking gait cycles remain to be fully understood.In this study,a hip joint simulator was therefore instrumented with an electrochemical cell for in-situ monitoring of the tribocorrosion evolution in a metal-on-polyethylene(MoP)THR during a typical long-term walking gait.In addition,the biotribocorrosion mechanism was investigated via surface and chemical characterizations.The experimental results confirmed that the taper/trunnion interface dominated the contemporary MoP hip joint corrosion.Three cyclic variations in the open circuit potential(OCP)were observed throughout the long-term electrochemical measurements,attributed to the formation and disruption of the adsorbed protein layer.The corrosion exhibited an initial increase at each period,peaking at approximately 0.125 million cycles,followed by a subsequent gradual reduction.Surface and chemical analyses revealed the formation of a tribochemical reaction layer(tribolayer)on the worn surface of the taper/trunnion interface.The surface/chemical characterizations and the electrochemical measurements indicated that the adhesion force of the adsorbed protein layer was weaker than that of the tribolayer.In contrast,the opposite was true for the corrosion resistance.Based on the observations from this study,the tribocorrosion mechanism of the taper/trunnion interface under the long-term walking gait cycles is deduced.
基金supported by the National Natural Science Foundation of China(Grant Nos.11875151,and 11522541)the Fundamental Research Funds for the Central Universities(Grant Nos.lzujbky2019-it21,and lzujbky-2019-ct06)。
文摘The destruction of a regular black hole event horizon might provide us the possibility to access regions inside black hole event horizon.This paper investigates the possibility of overcharging a charged Taub-NUT regular black hole via the scattering of a charged field and the absorption of a charged particle.For the charged scalar field scattering,both the near-extremal and extremal charged Taub-NUT regular black holes cannot be overcharged.For the test charged particle absorption,the result shows that the event horizon of the extremal charged Taub-NUT regular black hole still exists while the event horizon of the near-extremal one can be destroyed.However,if the charge and energy cross the event horizon in a continuous path,the near-extremal charged Taub-NUT regular black hole might not be overcharged.
