Hypersensitivity Reaction Caused by Intravenous Gadolinium-based MRI Contrast Agents

Objective To present a rare case of skin allergic reaction to gadobutrol,a magnetic resonance imaging(MRI)contrast agent,in a 37-year-old man.Methods The adverse reactions of gadobutrol were analyzed combined with the instructions and related literatures.Results and Conclusion The presence of this patient is consistent with the adverse reactions in the instructions of gadobutrol.The incidence of ADR in gadobutrol is considered to be low,although sometimes patients report a hypersensitivity reaction when undergoing MRI.There are only a few cases of immediate adverse reactions to gadobutrol.However,we should improve the ability of medical staff to use drugs safely and take preventive measures.

锝[^(99)Tc]亚甲基二膦酸盐治疗骨质疏松症的研究进展

目的分析概述锝[^(99)Tc]亚甲基二膦酸盐(^(99)Tc-MDP)治疗骨质疏松症(OP)的药理作用和临床应用研究进展。方法通过检索PubMed、CBM、CNKI、万方、维普等国内外数据库,归纳总结有关^(99)Tc-MDP治疗OP的药理作用和临床研究。结果^(99)Tc-MDP具有抑制破骨细胞活性、影响细胞因子表达、促进骨形成等作用,目前广泛应用于各种原发性和继发性骨质疏松症。结论 ^(99)Tc-MDP用于治疗OP具有疗效好、不良反应少等优点,值得临床进一步推广。