Construction of clinical research nurse training program based on position competence

BACKGROUND As one of the most important members in clinical trials,the number of clinical research nurses(CRN)can't keep up with the growth of experimental projects,so it is urgent to build clinical research training and strengthen the background knowledge of nurses.AIM To construct CRN training program based on position competence,accelerate the construction of CRN talent pool,and provide scientific guidance significance for CRN training.METHODS Based on the position competence model,combined with literature research and qualitative interview results,the first draft was prepared of the CRN training program.Two rounds of correspondence with 16 experts were conducted using the Delphi method to determine the training program.RESULTS The effective recovery rate of the expert correspondence questionnaire was 100%and the authority coefficients of the 2 rounds of experts were 0.826 and 0.895.Finally,4 first-level indicators and determine 15 s-level indicators of training objectives.The training program included 4 first-level indicators,training requirements,content,methods,assessment and evaluation,15 s-level indicators,and 74 third-level indicators.CONCLUSION The CRN training program based on position competence is scientific and extendable,providing a basis for participation in CRN training.

Intrathecal dexamethasone and methotrexate treatment of neoplastic meningitis from solid tumors

Aim:Neoplastic meningitis(NM)from solid tumors is an advanced malignancy with poor prognosis.Intrathecal chemotherapy is a reliable treatment,and we have obtained some experiences in the treatment of NM with intrathecal dexamethasone and methotrexate(IT DXM and MTX).Methods:Retrospective study of 23 patients with NM from lung cancer(n=11),breast cancer(n=3),gastric cancer(n=1),malignant melanoma(n=1),unknown cancer(n=7)was conducted.Among these patients,eight received IT DXM and MTX treatment,and 15 patients were placed into a palliative care group.Overall survival(OS)was compared,and the patients’characteristics,symptoms,and some laboratory examinations were analyzed to find the risk factors affecting OS.Results:OS of IT DXM and MTX group was significantly longer than that of the palliative care group(P=0.01).The median survival(MS)of palliative care group was 7.53 weeks(5.50-9.57;n=15),and of the IT DXM and MTX group,28.63 weeks(12.50-44.75;n=8);IT DXM and MTX prolonged the OS of NM patients(regression coefficient=−2.923),with odds ratio(OR)being 0.054(0.09-0.323).Spinal nerves damage decreased the OS(regression coefficient=1.595),with OR being 4.928(1.382-17.579).Conclusion:IT DXM and MTX have prolonged the patients’MS,which could be used as a fundamental treatment of NM.Time of induction treatment should be flexible and individualized,and induction treatment could restart when central nervous system relapse.Patients with spinal nerves damage are apt to live shorter.