Eukaryotes package their DNA into chromatin with histones. An ever-growing number of histone post-translational modifications have been discovered, which facilitate and modulate chromatinbased fundamental processes, s...Eukaryotes package their DNA into chromatin with histones. An ever-growing number of histone post-translational modifications have been discovered, which facilitate and modulate chromatinbased fundamental processes, such as transcription, DNA damage repair, and DNA replication. Lysine residues are the most modified histone residues. Acetylation and methylation on lysine residues are the two most studied histone modifications, and they differ greatly in one biophysical property.展开更多
Heart regeneration is a fascinating and complex biological process. Decades of intensive studies have revealed asophisticated molecular network regulating cardiac regeneration in the zebrafish and neonatal mouse heart...Heart regeneration is a fascinating and complex biological process. Decades of intensive studies have revealed asophisticated molecular network regulating cardiac regeneration in the zebrafish and neonatal mouse heart. Here,we review both the classical and recent literature on the molecular and cellular mechanisms underlying heartregeneration, with a particular focus on how injury triggers the cell-cycle re-entry of quiescent cardiomyocytes toreplenish their massive loss after myocardial infarction or ventricular resection. We highlight several importantsignaling pathways for cardiomyocyte proliferation and propose a working model of how these injury-inducedsignals promote cardiomyocyte proliferation. Thus, this concise review provides up-to-date research progresses onheart regeneration for investigators in the field of regeneration biology.展开更多
Organ regeneration is an important, fascinating, and old topic while much remains unknown in spite of extensiveinvestigations for decades. From March 25th to 27th, 2021, the Third Chinese Symposium on Organ Regenerati...Organ regeneration is an important, fascinating, and old topic while much remains unknown in spite of extensiveinvestigations for decades. From March 25th to 27th, 2021, the Third Chinese Symposium on Organ Regenerationtook place in the beautiful ocean city of Zhoushan, Zhejiang, China. This biennial conference attracted ~ 300 academicattendees: students, postdoctoral fellows, and principal investigators, in addition to few industrial investigators.The mixed live and virtual talks covered the broad field of organ regeneration from different animal organisms tohuman organoids, and concluded with some impressive advances on inflammatory signaling, regenerative signalingmechanisms, new technologies, and applications for organ regeneration.展开更多
基金supported by the National Natural Science Foundation of China (32288102)the K.C.Wong Educational Foundation (GJTD-2020-06)the Youth Innovation Promotion Association (2020097) of the Chinese Academy of Sciences。
文摘Eukaryotes package their DNA into chromatin with histones. An ever-growing number of histone post-translational modifications have been discovered, which facilitate and modulate chromatinbased fundamental processes, such as transcription, DNA damage repair, and DNA replication. Lysine residues are the most modified histone residues. Acetylation and methylation on lysine residues are the two most studied histone modifications, and they differ greatly in one biophysical property.
基金This paper was supported by grants from the National Key Research&Development Program of China(2018YFA080051)the National Natural Science Foundation of China(31730061 and 81870198).
文摘Heart regeneration is a fascinating and complex biological process. Decades of intensive studies have revealed asophisticated molecular network regulating cardiac regeneration in the zebrafish and neonatal mouse heart. Here,we review both the classical and recent literature on the molecular and cellular mechanisms underlying heartregeneration, with a particular focus on how injury triggers the cell-cycle re-entry of quiescent cardiomyocytes toreplenish their massive loss after myocardial infarction or ventricular resection. We highlight several importantsignaling pathways for cardiomyocyte proliferation and propose a working model of how these injury-inducedsignals promote cardiomyocyte proliferation. Thus, this concise review provides up-to-date research progresses onheart regeneration for investigators in the field of regeneration biology.
基金The authors were supported by grants from the National Key R&D Program of China(2018YFA0800501 and 2019YFA0801602)the National Natural Science Foundation of China(31730061 and 31430059)。
文摘Organ regeneration is an important, fascinating, and old topic while much remains unknown in spite of extensiveinvestigations for decades. From March 25th to 27th, 2021, the Third Chinese Symposium on Organ Regenerationtook place in the beautiful ocean city of Zhoushan, Zhejiang, China. This biennial conference attracted ~ 300 academicattendees: students, postdoctoral fellows, and principal investigators, in addition to few industrial investigators.The mixed live and virtual talks covered the broad field of organ regeneration from different animal organisms tohuman organoids, and concluded with some impressive advances on inflammatory signaling, regenerative signalingmechanisms, new technologies, and applications for organ regeneration.
