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Milk fat globule epidermal growth factor 8 alleviates liver injury in severe acute pancreatitis by restoring autophagy flux and inhibiting ferroptosis in hepatocytes
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作者 qing cui Hang-Cheng Liu +5 位作者 Wu-Ming Liu Feng Ma Yi Lv Jian-Cang Ma Rong-Qian Wu Yi-Fan Ren 《World Journal of Gastroenterology》 SCIE CAS 2024年第7期728-741,共14页
BACKGROUND Liver injury is common in severe acute pancreatitis(SAP).Excessive autophagy often leads to an imbalance of homeostasis in hepatocytes,which induces lipid peroxidation and mitochondrial iron deposition and ... BACKGROUND Liver injury is common in severe acute pancreatitis(SAP).Excessive autophagy often leads to an imbalance of homeostasis in hepatocytes,which induces lipid peroxidation and mitochondrial iron deposition and ultimately leads to ferroptosis.Our previous study found that milk fat globule epidermal growth factor 8(MFG-E8)alleviates acinar cell damage during SAP via binding toαvβ3/5 integrins.MFG-E8 also seems to mitigate pancreatic fibrosis via inhibiting chaperone-mediated autophagy.AIM To speculate whether MFG-E8 could also alleviate SAP induced liver injury by restoring the abnormal autophagy flux.METHODS SAP was induced in mice by 2 hly intraperitoneal injections of 4.0 g/kg L-arginine or 7 hly injections of 50μg/kg cerulein plus lipopolysaccharide.mfge8-knockout mice were used to study the effect of MFG-E8 deficiency on SAPinduced liver injury.Cilengitide,a specificαvβ3/5 integrin inhibitor,was used to investigate the possible mechanism of MFG-E8.RESULTS The results showed that MFG-E8 deficiency aggravated SAP-induced liver injury in mice,enhanced autophagy flux in hepatocyte,and worsened the degree of ferroptosis.Exogenous MFG-E8 reduced SAP-induced liver injury in a dose-dependent manner.Mechanistically,MFG-E8 mitigated excessive autophagy and inhibited ferroptosis in liver cells.Cilengitide abolished MFG-E8’s beneficial effects in SAP-induced liver injury.CONCLUSION MFG-E8 acts as an endogenous protective mediator in SAP-induced liver injury.MFG-E8 alleviates the excessive autophagy and inhibits ferroptosis in hepatocytes by binding to integrinαVβ3/5. 展开更多
关键词 Autophagy flux Ferroptosis Liver injury Milk fat globule epidermal growth factor 8 αvβ3/5 integrins Acute pancreatitis
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An Alternating Iterative Method and Its Application in Statistical Inference 被引量:4
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作者 Ning Zhong SHI Guo Rong HU qing cui 《Acta Mathematica Sinica,English Series》 SCIE CSCD 2008年第5期843-856,共14页
This paper studies non-convex programming problems. It is known that, in statistical inference, many constrained estimation problems may be expressed as convex programming problems. However, in many practical problems... This paper studies non-convex programming problems. It is known that, in statistical inference, many constrained estimation problems may be expressed as convex programming problems. However, in many practical problems, the objective functions are not convex. In this paper, we give a definition of a semi-convex objective function and discuss the corresponding non-convex programming problems. A two-step iterative algorithm called the alternating iterative method is proposed for finding solutions for such problems. The method is illustrated by three examples in constrained estimation problems given in Sasabuchi et al. (Biometrika, 72, 465472 (1983)), Shi N. Z. (J. Multivariate Anal., 50, 282-293 (1994)) and El Barmi H. and Dykstra R. (Ann. Statist., 26, 1878 1893 (1998)). 展开更多
关键词 semi-convex function alternating iterative method accumulation point maximum likelihood estimation order restriction
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Unique fluorescence properties of a self-assembling bis-pyrene molecule
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作者 Zhaozhong Li Yang Li +4 位作者 Dong Wang qing cui Zhengqiang Li Lei Wang Huai Yang 《Chinese Chemical Letters》 SCIE CAS CSCD 2018年第11期1645-1647,共3页
A self-assembling bis-pyrene (BP) molecule with π-π interactions was designed and synthesized. In condensed state, the BP self-assembled into highly-ordered mesophase at room temperature, which was characterized b... A self-assembling bis-pyrene (BP) molecule with π-π interactions was designed and synthesized. In condensed state, the BP self-assembled into highly-ordered mesophase at room temperature, which was characterized by using differential scanning calorimetry (DSC), polarized optical microscope (POM), and 1 D wide angle X-ray diffraction (WAXD) techniques. In solution, the BP self-assembled into nanoflbers in the mixed dichloromethane and hexane (1:1 volume ratio) solvent. Interestingly, the BP was not fluorescent when dissolved in dichloromethane solution. However, the self-assembled nanostructures of BP in the mixed solvent showed high intensity of green fluorescence. The advantages of self-assembly and fluorescence feature exhibited that BP could be promising fluorescence nanoprobes or nanosensors for various applications. 展开更多
关键词 Bis-pyrene FLUORESCENCE Self-assembly MESOPHASE π-π Interaction
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我国工伤保险事故预防机制初探——激励相容约束理论的视角
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作者 崔庆 《中国公共政策评论》 2011年第1期39-49,共11页
近年来,我国工伤事故频发、职业安全形势严峻,工伤保险事故预防没有发挥其应有的作用。本文在借鉴已有研究的基础上,对我国工伤保险事故预防机制的制度设计及现状进行博弈分析。并基于激励相容约束理论,分析当前我国工伤保险事故预防机... 近年来,我国工伤事故频发、职业安全形势严峻,工伤保险事故预防没有发挥其应有的作用。本文在借鉴已有研究的基础上,对我国工伤保险事故预防机制的制度设计及现状进行博弈分析。并基于激励相容约束理论,分析当前我国工伤保险事故预防机制的激励约束条件,得出我国工伤保险事故预防机制没有发挥有效作用的主要原因在于激励机制不合理,最后在已有法律框架内提出相应的政策建议。 展开更多
关键词 工伤保险 预防机制 激励相容
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