Preliminary Model Study for Forecasting a Hot Weather Process in Guangdong Province Using CMA-TRAMS

In this paper, the CMA-TRAMS tropical high-resolution system was used to forecast a typical hot weather process in Guangdong, China with different horizontal resolutions and surface coverage. The results of resolutions of 0.02° and 0.06° were presented with the same surface coverage of the GlobeLand30 V2020, companies with the results of resolution 0.02° with the USGS global surface coverage. The results showed that, on the overall assessment the 2 km model performed better in forecasting 2 m temperature, while the 6 km model was more accurate in predicting 10 m wind speed. In the evaluation of representative stations, the 2 km model performed better in forecasting 2 m temperature and 2 m relative humidity at the coastal stations, and the 2 km model was also better in forecasting 2 m pressure at the representative stations. However, the 6 km model performed better in forecasting 10 m wind speed at the representative stations. Furthermore, the 2 km model, owing to its higher horizontal resolution, presented a more detailed stratification of various meteorological field maps, allowing for a more pronounced simulation of local meteorological element variations. And the use of the surface coverage data of the GlobeLand30 V2020 improved the forecasting of 2 m temperature, and 10 m wind speed compared to the USGS surface coverage data.

Uncovering potential distinctive acoustic features of healing music

S Background Music therapy is a promising complementary intervention for addressing various mental health conditions.Despite evidence of the beneficial effects of music,the acoustic features that make music effective in therapeutic contexts remain elusive.Aims This study aimed to identify and validate distinctive acoustic features of healing music.Methods We constructed a healing music dataset(HMD)based on nominations from related professionals and extracted 370 acoustic features.Healing-distinctive acoustic features were identified as those that were(1)independent from genre within the HMD,(2)significantly different from music pieces in a classical music dataset(CMD)and(3)similar to pieces in a five-element music dataset(FEMD).We validated the identified features by comparing jazz pieces in the HMD with a jazz music dataset(JMD).We also examined the emotional properties of the features in a Chinese affective music system(CAMS).Results The HMD comprised 165 pieces.Among all the acoustic features,74.59%shared commonalities across genres,and 26.22%significantly differed between the HMD classical pieces and the CMD.The equivalence test showed that the HMD and FEMD did not differ significantly in 9.46%of the features.The potential healing-distinctive acoustic features were identified as the standard deviation of the roughness,mean and period entropy of the third coefficient of the mel-frequency cepstral coefficients.In a three-dimensional space defined by these features,HMD's jazz pieces could be distinguished from those of the JMD.These three features could significantly predict both subjective valence and arousal ratings in the CAMS.Conclusions The distinctive acoustic features of healing music that have been identified and validated in this study have implications for the development of artificial intelligence models for identifying therapeutic music,particularly in contexts where access to professional expertise may be limited.This study contributes to the growing body of research exploring the potential of digital technologies for healthcare interventions.

砂砾岩体沉积期次划分及其与物性的关系——以东营凹陷北部陡坡带Y920区块沙四上亚段为例

砂砾岩体储层岩性复杂、非均质性强,且扇体多期叠置,沉积期次划分困难。以东营凹陷北部陡坡带Y920区块沙四上亚段砂砾岩体为研究对象,建立以岩心、FMI图像为基础,以测井信息小波变换技术为核心,以三维地震为约束的砂砾岩扇体沉积期次划分方法。基于岩心、FMI图像可直观识别沉积期次界面,进而标定常规测井资料;经测井信息小波变换后表现出周期性振荡特征的小波系数曲线可反映沉积界面响应特征,结合功率谱筛选尺度因子,可定量对单井沉积期次进行划分;通过井-震结合,实现全区域期次界面的等时对比,将Y920区块砂砾岩体划分为8个沉积期次。沉积期次的发育控制着沉积相及岩性的分布,与物性展布也密切相关。研究结果表明,研究区块地层自下而上(8至1沉积期次)表现出退积沉积初始阶段(扇根—扇中)沉积期次中上部物性较好,沉积中间阶段(扇中)整个沉积期次物性均较好,而沉积末期阶段(扇中—扇端)沉积期次中下部物性较好,进而统计单井各期次有效储层的厚度,分期次刻画有效储层平面展布特征,发现3,4,5沉积期次的西北部为Y920区块有利储层展布范围。研究结果为东营凹陷北部陡坡带砂砾岩体油藏的精细勘探开发提供了依据。

Serum Helicobacter pylori Kat A and Ahp C antibodies as novel biomarkers for gastric cancer

AIM: To investigate catalase(Kat A) and alkyl hydroperoxide reductase(Ahp C) antibodies of Helicobacter pylori as biomarkers for gastric cancer(GC).METHODS: This study included 232 cases and 264 controls. Recombinant Kat A and Ahp C proteins were constructed and the levels of antibodies were tested by indirect enzyme-linked immunosorbent assay(ELISA). Logistic regression was applied to analyze the relationships between Kat A, Ahp C and GC. The χ2 trend test was used to evaluate the dose-response relationships between serum Kat A and Ahp C antibody levels and GC. Receiver operating characteristic(ROC) curve was used to evaluate the screening accuracy of Kat A and Ahp C as biomarkers. Combined analysis was used to observe screening accuracy of predictors for GC.RESULTS: In all subjects, the association between Kat A and Ahp C and GC risk was significant(P < 0.001) with odds ratio(OR) = 12.84(95%CI: 7.79-21.15)and OR = 2.4(95%CI: 1.55-3.73), respectively. Kat A and Ahp C antibody levels were strongly related to GC risk with a dose-dependent effect(P for trend < 0.001). The area under the ROC(AUC) for Kat A was 0.806, providing a sensitivity of 66.81% and specificity of 86.36%; and the AUC for Ahp C was 0.615, with a sensitivity of 75.65% and specificity of 45.49%. The AUC was 0.906 for Kat A and flagella protein A(Fla A) combined analysis.CONCLUSION: Serum Kat A and Ahp C antibodies are associated with GC risk and Kat A may serve as a biomarker for GC. Kat A/Fla A combined analysis improved screening accuracy.

认知矫正治疗在精神障碍治疗中的应用（英文）

概述:精神障碍患者普遍存在认知功能缺陷,目前唯一对改善认知功能缺陷有效的手段是认知矫正治疗。本文综述了认知矫正治疗在精神障碍患者治疗中的应用。

Discordance between family report and clinical assessment of suicide attempts: a prospective study from the emergency department

background Developing accurate identification methods for individuals with suicide attempts and providing them with follow-up care and supports can be a vital component of all comprehensive suicide prevention strategies.However,because of the difficulties concerning one’s intentions behind injurious behaviour,identifying suicide attempts is a challenge for families and clinicians.Aims The aim of this study was to investigate the differences between family report and clinical assessment for suicide attempts in the emergency department(ED).Methods A total of 148 patients with suspected suicide attempts(SSAs)and 148 family caregivers in the ED were enrolled.The suicide risk module of the Chinese version of the MINI International Neuropsychiatric Interview and the self-report measure were used to assess those with SSA’s suicidal behaviours.The Family Adaptability and Cohesion Evaluation Scales and semi-structured interviews were used to investigate the characteristics of suicide risk and demographics of patients with SSA,as well as the rate and influencing factors of omitted suicide attempts reported by family caregivers.results The underreporting rate for family reported suicide attempts in the ED was 69.0%.The suicide attempts group indicated lower mean scores on perceptions of family resources,adaptability and cohesion.Patients'suicide risk rating(OR=0.152,95%CI:0.037 to 0.620,p=0.009),adult-children relationship(OR=5.037,95%CI:1.478 to 17.167,p=0.010)and caregiver’s age(OR=0.279,95%CI:0.103 to 0.757,p=0.012)might be associated with underreporting by families.If patients committed suicide attempts through a falling injury or medication overdose,their families may have misreported the suicide attempt.Conclusions The discordance of suicide attempt records between family report and clinical assessment reveals the limitations of family self-reports when identifying suicide attempts.Interviews and observations,together with information from certain diagnoses,should be combined to accurately identify suicide attempters in the ED.

GSZ Formula Enhances Sleep Quality:Exploring Its Active Ingredients and Mechanism Using a Network Medicine Approach

Background:Sleep is essential for maintaining human health,and insomnia is a widespread problem.Traditional Chinese medicine(TCM)has been used for centuries to treat sleep disorders,with fewer reported side effects compared to conventional treatments.Objective:This study seeks to investigate the sleep-promoting effects of the GSZ formula,which comprisesγ-aminobutyric acid(GABA),Schisandrae Chinensis Fructus(Wuweizi in Chinese),and Ziziphi Spinosae Semen(Suanzaoren in Chinese).In addition,this study aims to explore the active ingredients and potential mechanisms underlying the sleep-enhancing effects of the formula.Methods:The impact of GSZ on sleep was evaluated using two models,the complete sleep model and the sub-threshold sleep model.Mice were randomly divided into five groups and orally administered GSZ solution(0.33 g/kg/day or 0.99 g/kg/day),positive drug diazepam(2.50 mg/kg)or a control solution for 30 days.Hypno-sis model was established in mice using pentobarbital sodium.Sleep duration and incidence were measured by recording when the righting reflex of mice disappeared for more than 1 min.GABA and dopamine(DA)levels in mouse brain tissue were measured using ELISA kits.The ingredients of the GSZ formula were identified using mass spectrometry,and the targets of these ingredients and disease-related genes were retrieved from public databases.A network medicine approach was used to calculate the shortest path between ingredient targets and disease-related proteins.The expression levels of potential proteins,such as Akt,p-Akt,GSK-3β,and p-GSK-3β,were analyzed using Western blotting based on the predicted results.Results:GSZ significantly prolonged sleep duration and enhanced the sleep rate in mice(P<0.05).Furthermore,it elevated GABA levels and reduced DA levels in the mouse brain(P<0.05).Network medicine analysis suggested that GABA,stearic acid,genistin,and coumestrol may be the most crucial active ingredients for sleep improve-ment.Western blotting analysis demonstrated that GSZ modulated the protein expression levels of p-Akt/Akt and p-GSK-3β/GSK-3β(P<0.05).Conclusion:Our study demonstrated that the GSZ formula could improve sleep,with key ingredients likely being GABA,stearic acid,genistin,and coumestrol.The mechanism might involve the regulation of the Akt/GSK-3βpathway,as revealed by the network medicine analysis and experimental validation.Our current new findings shed light on the potential mechanisms underlying the sleep-enhancing effects of the GSZ formula,which could provide experimental evidence to develop innovative treatments for insomnia.

Review of Geostationary Interferometric Infrared Sounder

To measure the global atmospheric three-dimensional distribution and change of temperature and humidity is one of the key areas in atmospheric remote sensing detection; it is also a new research and development direction in the field of meteorological satellite application. As a main element of China second generation of geostationary meteorological satellite Fengyun 4 （FY-4）, which was launched on Dec. 11, 2016, the Geostationary Interferometric Infrared Sounder （GIIRS） is the first interferometric infrared sounder working on the international geostationary orbit. It is used for vertical atmospheric sounding and gains atmospheric temperature, humidity, and disturbances. The combination of Fourier transform spectrometer technology and infrared detectors makes GIIRS have high spectral resolution and large coverage over spatial areas. With this kind of instrument, meteoro- logical satellites can improve the capabilities for severe weather event monitoring and numerical weather prediction. Here a concise review of the GIIRS development project, including its history, missions and functions, technical design, key technologies, system integration, calibration and in-orbit operation status, etc., is presented.

Pivotal roles of tumor-draining lymph nodes in the abscopal effects from combined immunotherapy and radiotherapy

Background:Currently,due to synergy enhancement of anti-tumor effects and potent stimulation of abscopal effects,combination therapy with irradiation and programmed cell death protein 1/programmed death-ligand 1(PD-1/PD-L1)immune checkpoint inhibition(immuno-radiotherapy,iRT)has revolutionized the therapeutic guidelines.It has been demonstrated that tumor-draining lymph nodes(TDLN)are essential for effective antitumor immunity induced by radiotherapy,immunotherapy,or iRT.Given that the function of TDLN in iRT remains unclear,this study aimed to investigate the function and mechanism of TDLN in iRT-induced abscopal effects.Methods:The function of TDLN was evaluated using unilateral or bilateral MC38 and B16F10 subcutaneous tumor models with or without indicated TDLN.The flow cytometry,multiple immunofluorescence analysis,and NanoString analysis were utilized to detect the composition and function of the immune cells in the primary and abscopal tumor microenvironment.Additionally,we tempted to interrogate the possible mechanisms via RNA-sequencing of tumor-infiltrating lymphocytes and TDLN.Results:TDLN deficiency impaired the control of tumor growth by monotherapy.Bilateral TDLN removal rather than unilateral TDLN removal substantially curtailed iRT-stimulated anti-tumor and abscopal effects.Furthermore,in the absence of TDLN,the infiltration of CD45+and CD8+T cells was substantially reduced in both primary and abscopal tumors,and the anti-tumor function of CD8+T cells was attenuated as well.Additionally,the polarization of tumor-associated macrophages in primary and abscopal tumors were found to be dependent on intact bilateral TDLN.RNA-sequencing data indicated that impaired infiltration and anti-tumor effects of immune cells partially attributed to the altered secretion of components from the tumor microenvironment.Conclusions:TDLN play a critical role in iRT by promoting the infiltration of CD8+T cells and maintaining the M1/M2 macrophage ratio.

Structural changes in the gray matter of unmedicated patients with obsessive-compulsive disorder: a voxel-based morphometric study

The aim of the current study was to use whole brain voxel-based morphometry（VBM）to assess the gray matter（GM）changes in unmedicated patients with obsessive-compulsive disorder（OCD）compared with normal controls.We compared the GM volumes in28 patients with 22 matched healthy controls using a1.5T MRI.Three-dimensional T1-weighted magnetic resonance images were obtained from all participants.VBM was performed to detect GM volume differences between the two groups.We detected increased regional GM volumes in the bilateral middle temporal gyri,bilateral middle occipital gyri,bilateral globus pallidus,right inferior parietal gyrus,left superior parietal gyrus,right parahippocampus,right supramarginal gyrus,right medial superior frontal gyrus,and left inferior frontal opercular cortex in the OCD patients relative to controls（P〈0.001,uncorrected,cluster size〉100 voxels）.No decreased GM volume was found in the OCD group compared with normal controls.Our findings suggest that structural changes in the GM are not limited to fronto-striato-thalamic circuits in the pathogenesis of OCD.Temporo-parietal cortex may also play an important role.

风向改变对非平角冠毛结构周围流场和拖曳力系数影响的数值研究

蒲公英种子的良好飞行能力归功于其冠毛结构特征.以往研究主要集中于风从蒲公英种子的冠毛结构底部通过至顶部(简称为“一型风”)时,空气流动与种子的相互作用.然而,由于大气流和种子结构特征的多样性,蒲公英种子从花序头部脱落或空中飞行过程中,风从蒲公英冠毛结构顶部通过至底部(简称为“二型风”)的情况也很常见.但是,目前尚缺乏二型风情况下空气流动与种子相互作用的相关研究.本文中,我们通过数值模拟,考虑风速、冠毛结构角度和孔隙率的变化,研究和比较了在两种风型下冠毛结构模型的拖曳力系数和周围流场分布特征。结果表明:由于风向的反转,流场分布特征和拖曳力系数会发生显著变化.当风从第一型转为第二型时,冠毛丝对气流的干扰从背风侧移前至迎风侧,导致在第二型风时涡环大多数情况下附着在非扁平冠毛结构模型的中心圆盘上,而在第一型风时则发生涡环分离。当风从第一型变为第二型时,压力诱导的拖曳力对总拖曳力的贡献显著增加,从而增强了非扁平冠毛结构模型的拖曳力系数.然而,随着风速、冠毛结构角度和孔隙率的增加,这种增强作用会逐渐减弱.这些发现将有助于种子风驱扩散的定量预测,并为微型仿生飞行器的设计提供一定指导.