Progress on the melanoidins produced by the Maillard reaction of fermented food and traditional Chinese medicine

FMs(Food-borne melanoidins)are brown high molecular weight polymers formed by the Mailiard reaction between carbohydrates and nitrogen-containing compounds during the processing of food or Traditional Chinese Medicine(TCM),and are widely found in food-borne products such as TCM concoctions,bakery,brewing,soy sauce,ferment and other food-borne products.FMs not only have a variety of biological activities,such as antioxidant,antibacterial,immunomodulation,regulation of intestinal flora,etc.,and can change the color,aroma and taste of food.The diversity of its components has become a research hotspot at home and abroad in recent years,with a wide range of application prospects.Therefore,this paper summarizes the existing information on FMs at home and abroad,mainly describes their preparation process,physicochemical properties,structural characteristics and functional activity research progress.Typical FMs,such as coffee,biscuits,wine and soy sauce in daily food,and Polygonatum,Perilla oil,Black ginseng,and Red jujube in T,were highlighted.Summarising the current status of research between the chemistry and pharmacodynamics of relevant FMs and presenting challenges and future recommendations for melanoidin research.In future research on FMs,one should pay more attention to basic research,especially isolation and purification and generation mechanisms,to further demonstrate the biological activity of FMs in vivo and in clinical trials.Thus,the potential value of its existence is deeply exploited to meet the needs of technology,production and health.

Discussion on the Talent Cultivation Strategy for Interior Design in Vocational Colleges from the Perspective of Industry-Education Integration

To further enhance the effectiveness of talent cultivation for interior design in vocational colleges,it is necessary to vigorously promote the construction of an industry-education integration model.Through this model,the roles of both enterprises and schools can be leveraged to jointly facilitate the continuous improvement of students’professional abilities and practical skills,providing a steady stream of high-quality talents for the development of the interior design field.Therefore,this paper analyzes the current issues in interior design talent cultivation in vocational colleges from the perspective of industry-education integration and proposes corresponding improvement measures.

Activation-induced pyroptosis contributes to the loss of MAIT cells in chronic HIV-1 infected patients

Background: Mucosal-associated invariant T(MAIT) cells are systemically depleted in human immunodeficiency virus type 1(HIV-1) infected patients and are not replenished even after successful combined antiretroviral therapy(cART).This study aimed to identify the mechanism underlying MAIT cell depletion.Methods: In the present study, we applied flow cytometry, single-cell RNA sequencing and immunohistochemical staining to evaluate the characteristics of pyroptotic MAIT cells in a total of 127 HIV-1 infected individuals, including 69 treatment-naive patients, 28 complete responders, 15 immunological non-responders, and 15 elite controllers, at the Fifth Medical Center of Chinese PLA General Hospital, Beijing, China.Results: Single-cell transcriptomic profiles revealed that circulating MAIT cells from HIV-1 infected subjects were highly activated, with upregulation of pyroptosis-related genes. Further analysis revealed that increased frequencies of pyroptotic MAIT cells correlated with markers of systemic T-cell activation, microbial translocation, and intestinal damage in cART-naive patients and poor CD4+ T-cell recovery in long-term cART patients. Immunohistochemical staining revealed that MAIT cells in the gut mucosa of HIV-1 infected patients exhibited a strong active gasdermin-D(GSDMD, marker of pyroptosis) signal near the cavity side, suggesting that these MAIT cells underwent active pyroptosis in the colorectal mucosa. Increased levels of the proinflammatory cytokines interleukin-12(IL-12) and IL-18 were observed in HIV-1 infected patients. In addition, activated MAIT cells exhibited an increased pyroptotic phenotype after being triggered by HIV-1 virions, T-cell receptor signals, IL-12 plus IL-18, and combinations of these factors, in vitro.Conclusions: Activation-induced MAIT cell pyroptosis contributes to the loss of MAIT cells in HIV-1 infected patients,which could potentiate disease progression and poor immune reconstitution.

Characteristic changes in astrocyte properties during astrocyte-to-neuron conversion induced by NeuroD1/Ascl1/Dlx2

Direct in vivo conversion of astrocytes into functional new neurons induced by neural transcription factors has been recognized as a potential new therapeutic intervention for neural injury and degenerative disorders. However, a few recent studies have claimed that neural transcription factors cannot convert astrocytes into neurons, attributing the converted neurons to pre-existing neurons mis-expressing transgenes. In this study, we overexpressed three distinct neural transcription factors––NeuroD1, Ascl1, and Dlx2––in reactive astrocytes in mouse cortices subjected to stab injury, resulting in a series of significant changes in astrocyte properties. Initially, the three neural transcription factors were exclusively expressed in the nuclei of astrocytes. Over time, however, these astrocytes gradually adopted neuronal morphology, and the neural transcription factors was gradually observed in the nuclei of neuron-like cells instead of astrocytes. Furthermore,we noted that transcription factor-infected astrocytes showed a progressive decrease in the expression of astrocytic markers AQP4(astrocyte endfeet signal), CX43(gap junction signal), and S100β. Importantly, none of these changes could be attributed to transgene leakage into preexisting neurons. Therefore, our findings suggest that neural transcription factors such as NeuroD1, Ascl1, and Dlx2 can effectively convert reactive astrocytes into neurons in the adult mammalian brain.

A generalized deep neural network approach for improving resolution of fluorescence microscopy images

Deep learning is capable of greatly promoting the progress of super-resolution imaging technology in terms of imaging and reconstruction speed,imaging resolution,and imagingflux.This paper proposes a deep neural network based on a generative adversarial network(GAN).The generator employs a U-Net-based network,which integrates Dense Net for the downsampling component.The proposed method has excellent properties,for example,the network model is trained with several different datasets of biological structures;the trained model can improve the imaging resolution of different microscopy imaging modalities such as confocal imaging and wide-field imaging;and the model demonstrates a generalized ability to improve the resolution of different biological structures even out of the datasets.In addition,experimental results showed that the method improved the resolution of caveolin-coated pits(CCPs)structures from 264 nm to 138 nm,a 1.91-fold increase,and nearly doubled the resolution of DNA molecules imaged while being transported through microfluidic channels.

Gestational diabetes mellitus combined with fulminant type 1 diabetes mellitus, four cases of double diabetes: A case report

BACKGROUND Fulminant type 1 diabetes mellitus(FT1DM)that occurs during pregnancy or the perinatal period is known as pregnancy-related FT1DM(PF),always without history of abnormal glucose metabolism.Here,we present four patients who developed FT1DM during treatment but were first diagnosed with gestational diabetes mellitus(GDM).CASE SUMMARY The clinical data of four patients with GDM combined with FT1DM admitted to our hospital between July 2018 and April 2021 were collected,and the patients and their infants were followed up.All patients were diagnosed with GDM during the second trimester and were treated.The blood glucose level elevated suddenly during the third trimester and then were diagnosed with FT1DM.Two patients had an insulin allergy,and two had symptoms of upper respiratory tract infection before onset.One patient developed ketoacidosis,and three developed ketosis.Two patients had cesarean section deliveries,and two had vaginal deliveries.The growth and development of the infants were normal.C-peptide levels were lower than those at onset,suggesting progressive impairment of islet function.The frequencies of the DRB109:01,DQB103:03,DQA103:02,DPA101:03,DPA102:02,DPB105:01,DRB401:03,G 01:01,and G 01:04 human leukocyte antigen(HLA)-G alleles were high in the present study.CONCLUSION In comparison with pregnancy-associated FT1DM(PF),patients with GDM combined with FT1DM had an older age of onset,higher body mass index,slower onset,fewer prodromal symptoms,and less acidosis.The pathogenesis may be due to various factors affecting the already fragileβ-cells of GDM patients with genetically susceptible class II HLA genotypes.We speculate that GDM combined with FT1DM during pregnancy,referred to as“double diabetes,”is a subtype of PF with its own unique characteristics that should be investigated further.

^(131)I-labeled metuximab combined with chemoembolization for unresectable hepatocellular carcinoma

AIM:To investigate the safety and effectiveness of combined131I-metuximab and transcatheter arterial chemoembolization(TACE)for hepatocellular carcinoma(HCC).METHODS:One hundred and eighty-five patients(159men and 26 women)with advanced HCC were enrolled in this study from February 2009 to July 2011.There were 95 patients in the combined metuximab and TACE group,and 90 patients in the TACE only group.The patients were followed for 12 mo.Clinical symptoms,blood cell counts,Karnofsky Performance Score(KPS)evaluation and therapeutic effects according to the Response Evaluation Criteria in Solid Tumors were recorded and evaluated.RESULTS:The 1-mo effective rates(complete response+partial response+stable disease)of the test group and control group were 71.23%and 38.89%,respectively(P<0.001).The 6-,9-and 12-mo survival rates were 86.42%,74.07%and 60.49%for the test group and 60.0%,42.22%and 34.44%for the control group(P<0.001).The incidence of adverse events(gastrointestinal symptoms,fever and pain)and blood cell toxicity were significantly higher for the test group than for the control group(P<0.001).No severe131Imetuximab-related complications were identified.With respect to efficacy,patients in the test group had greater improvement in tumor-related pain(P=0.014)and increase in KPS(P<0.001)than those in the control group.CONCLUSION:Combination of131I-metuximab and TACE prolonged the survival time in patients with HCC compared with TACE alone.The combination treatment was safe and effective.

Spatio-temporal variability of phytoplankton assemblages and its controlling factors in spring and summer in the Subei Shoal of Yellow Sea, China

The Subei Shoal is a special coastal area with complex physical oceanographic properties in the Yellow Sea.In the present study,the distribution of phytoplankton and its correlation with environmental factors were studied during spring and summer of 2012 in the Subei Shoal of the Yellow Sea.Phytoplankton species composition and abundance data were accomplished by Utermohl method.Diatoms represented the greatest cellular abundance during the study period.In spring,the phytoplankton cell abundance ranged from 1.59×10^3 to 269.78×10^3 cell/L with an average of 41.80×10^3 cell/L,and Skeletonema sp.and Paralia sulcata was the most dominant species.In summer,the average phytoplankton cell abundance was 72.59×10^3 cell/L with the range of 1.78×10^3 to 574.96×10^3 cell/L,and the main dominant species was Pseudo-nitzschia pungens,Skeletonema sp.,Dactyliosolen fragilissima and Chaetoceros curvisetus.The results of a redundancy analysis(RDA)showed that turbidity,temperature,salinity,pH,dissolved oxygen(DO),the ratio of dissolved inorganic nitrogen to silicate and SiO4-Si(DIN/SiO4-Si)were the most important environmental factors controlling phytoplankton assemblages in spring or summer in the Subei Shoal of the Yellow Sea.

Near-surface sand-dust horizontal flux in Tazhong-the hinterland of the Taklimakan Desert

Tazhong is the hinterland and a sandstorm high-frequency area of the Taklimakan Desert. However, little is known about the detailed time-series of aeolian sand transport in this area. An experiment to study the sand-dust horizontal flux of near-surface was carried out in Tazhong from January to December 2009. By measur- ing the sand-dust horizontal flux throughout sixteen sand-dust weather processes with a 200-cm tall Big Spring Number Eight （BSNE） sampler tower, we quantitatively analyzed the vertical variation of the sand-dust horizontal flux. And the total sand-dust horizontal flux of different time-series that passed through a section of 100 cm in width and 200 cm in height was estimated combining the data of saltation movement continuously recorded by piezo- electric saltation sensors （Sensit）. The results indicated that, in the surface layer ranging from 0-200 cm, the inten- sity of sand-dust horizontal flux decreased with the increase of the height, and the physical quantities obeyed power function well. The total sand-dust horizontal flux of the sixteen sand-dust weather processes that passed through a section of 100 cm in width and 200 cm in height was about 2,144.9 kg, the maximum of one sand-dust weather event was about 396.3 kg, and the annual total sand-dust horizontal flux was about 3,903.2 kg. The high levels of aeolian sand transport occurred during daytime, especially from 13：00 to 16：00 in the afternoon. We try to develop a new method for estimation of the detailed time-series of aeolian sand transport.

2019 Chinese guideline for the management of hypertension in the elderly

Table of contents Preamble 1 Introduction 1.1 Class of recommendations and level of evidences 1.2 Definition and categories of hypertension in the elderly 1.3 Current status of epidemiology of hypertension in the elderly 1.4 The characteristics of hypertension in the elderly.

Efficacy of a Chinese herbal formula on hepatitis B e antigenpositive chronic hepatitis B patients

BACKGROUND No guideline recommends antiviral therapy for hepatitis B e antigen(HBeAg)-positive chronic hepatitis B patients with persistently normal alanine aminotransferase levels and a high hepatitis B virus(HBV)DNA viral load.AIM To evaluate the feasibility and safety of a Chinese herbal formula as a therapeutic option for chronic HBV infection.METHODS In total,395 patients(30–65 years old)with confirmed HBeAg-positive chronic hepatitis B infection and persistently normal alanine aminotransferase were randomized to receive either Chinese herbal formula or placebo for 96 wk.Endpoints to evaluate therapeutic efficacy included:(1)HBV DNA levels decreased to less than 4 log10 IU/mL at weeks 48 and 96;and(2)HBeAg clearance and seroconversion rates at weeks 48 and 96.RESULTS HBV DNA levels≤4 log10 IU/mL were 10.05%at week 48 and 18.59%at week 96 in the treatment group.The HBeAg clearance and conversion rates were 8.54%and 8.04%at week 48 and 16.08%and 14.57%at week 96,respectively.However,HBV DNA levels≤4 log10 IU/mL were 2.55%and 2.55%at weeks 48 and 96,respectively,and the HBeAg clearance rates were 3.06%and 5.61%at weeks 48 and 96,respectively,in the control group.The quantitative hepatitis B surface antigen and HBeAg levels at baseline and changes during the treatment period as well as the alanine aminotransferase elevation at weeks 12 and 24 were strong predictors of HBeAg clearance.CONCLUSION High rates of HBV DNA reduction,HBeAg clearance and seroconversion could be achieved with Chinese herbal formula treatments,and the treatments were relatively safe for HBeAg-positive chronic hepatitis B-infected patients with persistently normal alanine aminotransferase.The ability of the compound to modulate host immune function probably contributed to this effect.

Impact factors of soil wind erosion in the center of Taklimakan Desert

The development and progress of soil wind erosion are influenced by the factors of climate, terrain, soil and vegetation, etc. This paper, taking Tazhong region, a town in the centre of the Taklimakan Desert, as an example and using comparative and quantitative methods, discussed the effects of climate, surface roughness （including vegetation cover） and surface soil properties on soil wind erosion. The results showed that the climate factor index C of annual wind erosion is 28.3, while the maximum of C is 13.9 in summer and it is only 0.7 in winter. The value of C has a very good exponential relationship with the wind speed. In Tazhong region, the surface roughness height is relatively small with a mean of 6.32 x 10 Sm, which is in favor of soil wind erosion. The wind erosion is further enhanced by its sandy soil types, soil particle size, lacking of vegetation and low soil moisture content. The present situation of soil wind erosion is the result of concurrent effects of climate, vegetation and surface soil properties.

Achievable complete remission of advanced non-small-cell lung cancer: Case report and review of the literature

Surgery is the first choice of treatment for patients with non-small-cell lung cancer(NSCLC), but few patients can be treated surgically because of either advanced disease or poor pulmonary function. Other therapies include radiotherapy and chemotherapy, as well as complementary and alternative therapies, usually with disappointing results. Bronchial artery infusion(BAI) is a manageable and effective method for treating advanced NSCLC. Outcome is good by BAI due to its repeatability and low toxicity. Icotinib hydrochloride is a newly developed and highly specific epidermal growth factor receptor(EGFR) tyrosine kinase inhibitor and has been safely and efficiently used to treat advanced NSCLC. We herein report a 73-year-old patient with chronic cough, who was diagnosed with advanced NSCLC with the EGFR mutation of L858 R substitution in exon 21, and treated with the combination of oral icotinib and BAI chemotherapy as the first-line therapy, which resulted in a satisfactory clinical outcome. Complete remission of advanced NSCLC can be achieved using the combination of oral icotinib and BAI chemotherapy.

Relationship between thermal anomalies in Tibetan Plateau and summer dust storm frequency over Tarim Basin,China

The dust storm is the most important and frequent meteorological disaster over Tarim Basin, which causes huge damages on local social economics. How to predict the springtime and summertime dust storm oc- currence has become a hot issue for meteorologists. This paper employed the data of dust storm frequency and 10-m wind velocity at 35 stations over Tarim Basin and the reanalysis data from the National Center for Environ- mental Prediction and the National Center for Atmospheric Research （NCEP/NCAR） during 1961-2007 to study the relationship between dust storm frequency （DSF） in summer over Tarim Basin and the thermal anomalies in Tibetan Plateau in May by using the statistical methods, such as Empirical Orthogonal Function （EOF）, correlation and binomial moving average. The results show when negative anomalies in Tibetan Plateau and positive anomalies in its southern region are present along 30~N （the second mode of surface temperature anomalies by EOF decomposition） in May, the time coefficient （PC2） plays an important role in summer DSF variation and has a close relation with the summer DSF at both inter-annual and decadal time scales. When negative anomalies in Tibetan Plateau and positive anomalies are present in its southern region （PC2 in positive phase）, there is an anomalous anticyclone in North China, which weakens the northwest wind and is not beneficial for cold air moving from high latitude to the Tarim Basin, and the circulation pattern is hard to result in dust storm weather. Furthermore, the sea level pressure （SLP） increased over Tarim Basin and the direction of SLP gradient reversed, which resulted in the 10-m wind velocity slowing down, so the DSF decreased. From above all, it can be conclude that the thermal anomalies in Tibetan Plateau in May has important effects on the summertime dust storm frequency over Tarim Basin and the PC2 can be used as a prediction factor for the summertime dust storm occurrence.

Vertical distribution characteristics of dust aerosol mass concentration in the Taklimakan Desert hinterland

The different height mass concentrations of dust aerosol data from the atmosphere environment observation station （Ta- zhong Station） was continuously observed by instruments of Grimm 1.108, Thermo RP 1400a and TSP from January of 2009 to February of 2010 in the Taklimakan Desert hinterland. Results show that： （1） The mass concentration value of 80 m PMl0 was higher, but PM2.5 and PM1.0 concentrations at 80 m was obviously lower than 4 m PMl0, and the value of 80 m PM1.0 mass concentration was the lowest. （2） The PM mass concentrations gradually decreased from night to sunrise, with the lowest concentration at 08：00, with the mass concentration gradually increased, up to the highest concentration around 18：00, and then decreased again. It was exactly the same with the changes of wind speed. （3） The high monthly average mass concentration of TSP mainly appeared from March to September, and the highest concentration was in April and May, subsequently gradually decreased. Also, March-September was a period with high value area of PM monthly average mass concentration, with the highest monthly average mass concentration of 846.0 p.g/m3 for 4 m PM^0 appeared in May. The concentration of PM10 was much higher than those of PM2.5 and PM1.0 at 80 m. There is a small difference between the concentration of PM2.5 and PM~ 0. Dust weather was the main factor which influenced the concentration content of the different diameter dust aerosol, and the more dust weather days, the higher content of coarse particle, conversely, fine particle was more. （4） The mass concentration of different diameter aerosols had the following sequence during dust weather： clear day 〈 blowing dust 〈 floating and blowing dust 〈 sandstorm. In different dust weather, the value of PM^o/TSP in fine weather was higher than that in floating weather, and much higher than those in blowing dust and sandstorm weather. （5） During the dust weather process, dust aerosol concentration gradually decreased with particle size decreasing. The dust aerosol mass concentration at different heights and diameter would have a peak value area every 3-4 days according to the strengthening process of dust weather.

农村寄宿制办学的未预期结果:基于就业外溢效应的考察

目前对农村寄宿制学校的研究主要集中于教育本身,忽略了寄宿对家庭经济行为的外溢效应。基于2010-2018年五轮中国家庭追踪调查数据,分析小学生寄宿对农村家庭劳动力就业的影响,发现家庭小学生全部寄宿使得家庭劳动力务工和务农比率分别提高3.2%和2.5%,有工作比率上升2.4%,这一效果不受性别和孩子数量影响,且对年轻人和受教育程度高的劳动力影响更大。机制分析发现:家庭小学生全部寄宿降低了家庭劳动力因家务而不就业的概率,主要体现在女性劳动力上;如家中有走读生、学前儿童或没有老人参与儿童照料,寄宿对劳动力就业没有显著影响。因此,寄宿制办学可通过降低照料负担而有效增加农村劳动力就业,这有助于进一步释放农村劳动力资源,增加农村家庭收入,从而有助于推进乡村振兴和实现共同富裕。

Chinese expert consensus on the management of hypertension in the very elderly

Population aging has become a major challenge for the healthcare in China. More than 23 million Chinese are cur- rently ≥ 80 years, with an annual increase of 5%. The Chi- nese population of 80 years or older is expected to reach 30.67 million by 2020 and 74 million by 2040.

The characteristics of grain size from the Kumtag Desert and its environmental significance

The Kumtag Desert is located in the arid northwestern portion of China,and is considered China’s sixth-largest desert.Grain-size analysis of the sand plays a very important role in differentiating sedimentary environments,determining the ways that sediments are transported,estimating hydrodynamic conditions,and analyzing grain-size trends.The analysis of the grain size of 20 sand samples that were taken from mid-northern,north margin,western,middle,southern,and southeast margins of the Kumtag Desert shows that grain sizes are vastly different.The grain-size parameters fall in the following range:the median diameter Mz = 1.55Φ-2.92Φ,the standard deviation σI= 0.41-1.11,the skewness SKI = ?0.11-0.31,kurtosis KG = 0.77-1.23.The frequency curves of grain size have characteristics with single peaks and multi-peaks,and most of the sand samples’ skewness appears close to asymmetric.The analytical results reveal that the sediments of the Kumtag Desert are complex and diverse,which affected by such forces as wind deposition,lacustrine sediment,and alluvial and proluvial river deposits.

The Relationship between Intrahepatic Distribution of Hepatitis B Virus Core Antigen and Serum ALT, HBV DNA Levels and HBeAg Status

Objective The clinical significance of differential distribution of hepatitis B virus(HBV)nucleocapsid antigen in hepatocytes remains unknown.The goal of this study is to determine the relationship between distinct HBV core antigen distribution pattern and alanine transaminase(ALT),liver histological inflammatory activity grades,serum HBeAg status and HBV DNA level.Methods Total of 958 cases with chronic hepatitis B were recruited into this study.Liver function tests,serum HBV DNA level,serological HBV markers and liver immunohistochemistry were examined according to the conventional instructions.Chi Square tests were performed to analyze the differences among these groups.Results It was found that 552(58%)cases were tested positive for HBV core antigen by immunohistochemical staining.Cytoplasmic hepatitis B core antigen(HBcAg)expression correlated with ALT level and serum HBV DNA and liver inflammatory activity scores,however,nuclear HBcAg expression in hepatocytes was associated with normal ALT level,lower liver inflammatory activity score and higher serum HBV DNA level and rate of HBeAg positivity.Both nuclear and cytoplasmic HBcAg expression in hepatocytes associated with a middle ALT level and liver inflammatory activity score,higher rate of serum detectable HBeAg and a higher HBV DNA level.However,undetectable core antigen was related to a lower ALT level and histological inflammatory activity grade,lower positive HBeAg rate and HBV DNA level.Conclusions Undetectable liver HBcAg is associated with HBV clearance,ALT normalization and hepatitis B e antigen(HBeAg)seroconversion,and cytoplasmic HBcAg expression associated with higher hepatic inflammatory activity.However,nuclear HBcAg expression correlates with immune tolerance characterized with normal ALT and lower liver inflammatory activity,higher HBV replication level and higher rate of HBeAg positivity.

Tetrahedral framework nucleic acid carrying angiogenic peptide prevents bisphosphonate-related osteonecrosis of the jaw by promoting angiogenesis

The significant clinical feature of bisphosphonate-related osteonecrosis of the jaw(BRONJ)is the exposure of the necrotic jaw.Other clinical manifestations include jaw pain,swelling,abscess,and skin fistula,which seriously affect the patients’life,and there is no radical cure.Thus,new methods need to be found to prevent the occurrence of BRONJ.Here,a novel nanoparticle,t FNA-KLT,was successfully synthesized by us,in which the nanoparticle tetrahedral framework nucleic acid(tFNA)was used for carrying angiogenic peptide,KLT,and then further enhanced angiogenesis.TFNA-KLT possessed the same characteristics as tFNA,such as simple synthesis,stable structure,and good biocompatibility.Meanwhile,tFNA enhanced the stability of KLT and carried more KLT to interact with endothelial cells.First,it was confirmed that tFNA-KLT had the superior angiogenic ability to tFNA and KLT both in vitro and in vivo.Then we apply tFNA-KLT to the prevention of BRONJ.The results showed that tFNA-KLT can effectively prevent the occurrence of BRONJ by accelerating angiogenesis.In summary,the prepared novel nanoparticle,tFNA-KLT,was firstly synthesized by us.It was also firstly confirmed by us that tFNA-KLT significantly enhanced angiogenesis and can effectively prevent the occurrence of BRONJ by accelerating angiogenesis,thus providing a new avenue for the prevention of BRONJ and a new choice for therapeutic angiogenesis.