Chemically, N-phosphoryl homo-serine was much more stable than the homologous compound phosphorylated serine. The latter was very reactive to undergo N -->O migration, formation of peptide and cyclophosphoroamidate...Chemically, N-phosphoryl homo-serine was much more stable than the homologous compound phosphorylated serine. The latter was very reactive to undergo N -->O migration, formation of peptide and cyclophosphoroamidate but not the former when they were warmed in alcohol or chloroform at 40 degreesC. For the N-phospho-homo-serine, only a small extent of ester exchange occurred on the phosphorus. A second type of penta-coordinate phosphorus intermediate was proposed.展开更多
文摘Chemically, N-phosphoryl homo-serine was much more stable than the homologous compound phosphorylated serine. The latter was very reactive to undergo N -->O migration, formation of peptide and cyclophosphoroamidate but not the former when they were warmed in alcohol or chloroform at 40 degreesC. For the N-phospho-homo-serine, only a small extent of ester exchange occurred on the phosphorus. A second type of penta-coordinate phosphorus intermediate was proposed.
