Monocular 6D pose estimation is a functional task in the field of com-puter vision and robotics.In recent years,2D-3D correspondence-based methods have achieved improved performance in multiview and depth data-based s...Monocular 6D pose estimation is a functional task in the field of com-puter vision and robotics.In recent years,2D-3D correspondence-based methods have achieved improved performance in multiview and depth data-based scenes.However,for monocular 6D pose estimation,these methods are affected by the prediction results of the 2D-3D correspondences and the robustness of the per-spective-n-point(PnP)algorithm.There is still a difference in the distance from the expected estimation effect.To obtain a more effective feature representation result,edge enhancement is proposed to increase the shape information of the object by analyzing the influence of inaccurate 2D-3D matching on 6D pose regression and comparing the effectiveness of the intermediate representation.Furthermore,although the transformation matrix is composed of rotation and translation matrices from 3D model points to 2D pixel points,the two variables are essentially different and the same network cannot be used for both variables in the regression process.Therefore,to improve the effectiveness of the PnP algo-rithm,this paper designs a dual-branch PnP network to predict rotation and trans-lation information.Finally,the proposed method is verified on the public LM,LM-O and YCB-Video datasets.The ADD(S)values of the proposed method are 94.2 and 62.84 on the LM and LM-O datasets,respectively.The AUC of ADD(-S)value on YCB-Video is 81.1.These experimental results show that the performance of the proposed method is superior to that of similar methods.展开更多
目的:分析纳武利尤单抗不良反应(ADR)发生的特点及规律,为临床合理用药提供参考。方法:检索中国知网、万方、维普、PubMed和Web of Science数据库,收集2018年6月–2021年1月关于纳武利尤单抗不良反应报道的文献,提取数据并进行分析。结...目的:分析纳武利尤单抗不良反应(ADR)发生的特点及规律,为临床合理用药提供参考。方法:检索中国知网、万方、维普、PubMed和Web of Science数据库,收集2018年6月–2021年1月关于纳武利尤单抗不良反应报道的文献,提取数据并进行分析。结果:共纳入73篇纳武利尤单抗所致ADR个案报道,涉及患者79例,多数患者年龄为60~69岁(30.38%),原发疾病以肺癌最多(41.77%);ADR发生时间多为用药后6个月内(74.69%);累及多个系统/器官,主要以皮肤及其附件损害(16.09%)、内分泌系统(14.94%)为主;停药和(或)对症治疗后好转或痊愈75例,死亡4例。好转后,再次给予纳武利尤单抗治疗16例,再次出现ADR 1例。结论:纳武利尤单抗所致ADR涉及不同年龄段患者,潜伏期长,累及多个系统/器官,临床使用时应加强用药安全性监测,警惕不良反应的发生,做到及时对症处理。展开更多
To reduce the energy consumption of the electrolytic hydrogen generation process, we propose a novel approach to generate hydrogen with acidic/alkaline amphoteric water electrolysis, wherein hydrogen is produced insid...To reduce the energy consumption of the electrolytic hydrogen generation process, we propose a novel approach to generate hydrogen with acidic/alkaline amphoteric water electrolysis, wherein hydrogen is produced inside an acidic solution and oxygen evolved under alkaline condition, and a membrane is employed in the middle of the electrolyzer to restrain neutralization. The electrode polarization is greatly reduced due to the specific arrangement of the acidic/alkaline amphoteric electrolyzer. The rate of hydrogen production achieves over four times higher than that of the alkaline aqueous solution at 2.2 V, and the energy consumption is reduced approximately 30% under the current density of 200 m A/cm ^2. The investigation of transmembrane potential drop indicates water splitting on the membrane surfaces, which compensates for acid or alkaline loss on-site and maintains the concentration approximately constant during electrolysis process. The acidic/alkaline amphoteric water electrolysis is promising as an energy saving, clean and sustainable hydrogen production technology.展开更多
Objective:The ongoing COVID-19 pandemic warrants accelerated efforts to test vaccine candidates.To explore the influencing factors on vaccine-induced effects,antibody responses to an inactivated SARS-CoV-2 vaccine in ...Objective:The ongoing COVID-19 pandemic warrants accelerated efforts to test vaccine candidates.To explore the influencing factors on vaccine-induced effects,antibody responses to an inactivated SARS-CoV-2 vaccine in healthy individuals who were not previously infected by COVID-19 were assessed.Methods:All subjects aged 18-60 years who did not have SARS-CoV-2 infection at the time of screening from June 19,2021,to July 02,2021,were approached for inclusion.All participants received two doses of inactivated SARS-CoV-2 vaccine.Serum IgM and IgG antibodies were detected using a commercial kit after the second dose of vaccination.A positive result was defined as 10 AU/mL or more and a negative result as less than 10 AU/mL.This retrospective study included 97 infection-naive individuals(mean age 35.6 years;37.1%male,62.9%female).Results:The seropositive rates of IgM and IgG antibody responses elicited after the second dose of inactivated SARS-CoV-2 vaccine were 3.1%and 74.2%,respectively.IgG antibody levels were significantly higher than IgM levels(P<0.0001).Sex had no effect on IgM and IgG antibody response after the second dose.The mean anti-IgG level in older persons(≥42 years)was significantly lower than that of younger recipients.There was a significantly lower antibody level at>42 days compared to that at 0-20 days(P<0.05)and 21-31 days(P<0.05)after the second dose.Conclusion:IgG antibody response could be induced by inactivated SARS-CoV-2 vaccine in healthy individuals(>18 years),which can be influenced by age and detection time after the second dose of vaccination.展开更多
Coronavirus disease 2019(COVID-19),which is caused by SARS-CoV-2,varies with regard to symptoms and mortality rates among populations.Humoral immunity plays critical roles in SARS-CoV-2 infection and recovery from COV...Coronavirus disease 2019(COVID-19),which is caused by SARS-CoV-2,varies with regard to symptoms and mortality rates among populations.Humoral immunity plays critical roles in SARS-CoV-2 infection and recovery from COVID-19.However,differences in immune responses and clinical features among COVID-19 patients remain largely unknown.Here,we report a database for COVID-19-specific IgG/IgM immune responses and clinical parameters(named COVID-ONE-hi).COVID-ONE-hi is based on the data that contain the IgG/IgM responses to 24 full-length/truncated proteins corresponding to 20 of 28 known SARS-CoV-2 proteins and 199 spike protein peptides against 2360 serum samples collected from 783 COVID-19 patients.In addition,96 clinical parameters for the 2360 serum samples and basic information for the 783 patients are integrated into the database.Furthermore,COVID-ONE-hi provides a dashboard for defining samples and a one-click analysis pipeline for a single group or paired groups.A set of samples of interest is easily defined by adjusting the scale bars of a variety of parameters.After the“START”button is clicked,one can readily obtain a comprehensive analysis report for further interpretation.COVID-ONE-hi is freely available at www.COVID-ONE.cn.展开更多
Photomosaic images are composite images composed of many small images called tiles.In its overall visual effect,a photomosaic image is similar to the target image,and photomosaics are also called“montage art”.Noisy ...Photomosaic images are composite images composed of many small images called tiles.In its overall visual effect,a photomosaic image is similar to the target image,and photomosaics are also called“montage art”.Noisy blocks and the loss of local information are the major obstacles in most methods or programs that create photomosaic images.To solve these problems and generate a photomosaic image in this study,we propose a tile selection method based on error minimization.A photomosaic image can be generated by partitioning the target image in a rectangular pattern,selecting appropriate tile images,and then adding them with a weight coefficient.Based on the principles of montage art,the quality of the generated photomosaic image can be evaluated by both global and local error.Under the proposed framework,via an error function analysis,the results show that selecting a tile image using a global minimum distance minimizes both the global error and the local error simultaneously.Moreover,the weight coefficient of the image superposition can be used to adjust the ratio of the global and local errors.Finally,to verify the proposed method,we built a new photomosaic creation dataset during this study.The experimental results show that the proposed method achieves a low mean absolute error and that the generated photomosaic images have a more artistic effect than do the existing approaches.展开更多
Serological tests play an essential role in monitoring and combating the COVID-19 pandemic.Recombinant spike protein(S protein),especially the S1 protein,is one of the major reagents used for serological tests.However...Serological tests play an essential role in monitoring and combating the COVID-19 pandemic.Recombinant spike protein(S protein),especially the S1 protein,is one of the major reagents used for serological tests.However,the high cost of S protein production and possible cross-reactivity with other human coronaviruses pose unavoidable challenges.By taking advantage of a peptide microarray with full spike protein coverage,we analyzed 2,434 sera from 858 COVID-19 patients,63 asymptomatic patients and 610 controls collected from multiple clinical centers.Based on the results,we identified several S protein-derived 12-mer peptides that have high diagnostic performance.In particular,for monitoring the IgG response,one peptide(aa 1148-1159 or S2-78)exhibited a sensitivity(95.5%,95%CI 93.7-96.9%)and specificity(96.7%,95%CI 94.8-98.0%)comparable to those of the S1 protein for the detection of both symptomatic and asymptomatic COVID-19 cases.Furthermore,the diagnostic performance of the S2-78(aa 1148-1159)IgG was successfully validated by ELISA in an independent sample cohort.A panel of four peptides,S1-93(aa 553-564),S1-97(aa 577-588),S1-101(aa 601-612)and S1-105(aa 625-636),that likely will avoid potential cross-reactivity with sera from patients infected by other coronaviruses was constructed.The peptides identified in this study may be applied independently or in combination with the S1 protein for accurate,affordable,and accessible COVID-19 diagnosis.展开更多
基金This work was supported by the National Natural Science Foundation of China(No.61871196 and 62001176)the Natural Science Foundation of Fujian Province of China(No.2019J01082 and 2020J01085)the Promotion Program for Young and Middle-aged Teachers in Science and Technology Research of Huaqiao University(ZQN-YX601).
文摘Monocular 6D pose estimation is a functional task in the field of com-puter vision and robotics.In recent years,2D-3D correspondence-based methods have achieved improved performance in multiview and depth data-based scenes.However,for monocular 6D pose estimation,these methods are affected by the prediction results of the 2D-3D correspondences and the robustness of the per-spective-n-point(PnP)algorithm.There is still a difference in the distance from the expected estimation effect.To obtain a more effective feature representation result,edge enhancement is proposed to increase the shape information of the object by analyzing the influence of inaccurate 2D-3D matching on 6D pose regression and comparing the effectiveness of the intermediate representation.Furthermore,although the transformation matrix is composed of rotation and translation matrices from 3D model points to 2D pixel points,the two variables are essentially different and the same network cannot be used for both variables in the regression process.Therefore,to improve the effectiveness of the PnP algo-rithm,this paper designs a dual-branch PnP network to predict rotation and trans-lation information.Finally,the proposed method is verified on the public LM,LM-O and YCB-Video datasets.The ADD(S)values of the proposed method are 94.2 and 62.84 on the LM and LM-O datasets,respectively.The AUC of ADD(-S)value on YCB-Video is 81.1.These experimental results show that the performance of the proposed method is superior to that of similar methods.
文摘目的:分析纳武利尤单抗不良反应(ADR)发生的特点及规律,为临床合理用药提供参考。方法:检索中国知网、万方、维普、PubMed和Web of Science数据库,收集2018年6月–2021年1月关于纳武利尤单抗不良反应报道的文献,提取数据并进行分析。结果:共纳入73篇纳武利尤单抗所致ADR个案报道,涉及患者79例,多数患者年龄为60~69岁(30.38%),原发疾病以肺癌最多(41.77%);ADR发生时间多为用药后6个月内(74.69%);累及多个系统/器官,主要以皮肤及其附件损害(16.09%)、内分泌系统(14.94%)为主;停药和(或)对症治疗后好转或痊愈75例,死亡4例。好转后,再次给予纳武利尤单抗治疗16例,再次出现ADR 1例。结论:纳武利尤单抗所致ADR涉及不同年龄段患者,潜伏期长,累及多个系统/器官,临床使用时应加强用药安全性监测,警惕不良反应的发生,做到及时对症处理。
基金financial support provided by the National Natural Science Foundation of China(21776154)the National High Technology Research and Development Program 863 (2012AA051203)
文摘To reduce the energy consumption of the electrolytic hydrogen generation process, we propose a novel approach to generate hydrogen with acidic/alkaline amphoteric water electrolysis, wherein hydrogen is produced inside an acidic solution and oxygen evolved under alkaline condition, and a membrane is employed in the middle of the electrolyzer to restrain neutralization. The electrode polarization is greatly reduced due to the specific arrangement of the acidic/alkaline amphoteric electrolyzer. The rate of hydrogen production achieves over four times higher than that of the alkaline aqueous solution at 2.2 V, and the energy consumption is reduced approximately 30% under the current density of 200 m A/cm ^2. The investigation of transmembrane potential drop indicates water splitting on the membrane surfaces, which compensates for acid or alkaline loss on-site and maintains the concentration approximately constant during electrolysis process. The acidic/alkaline amphoteric water electrolysis is promising as an energy saving, clean and sustainable hydrogen production technology.
基金supported by grants from the Applied Basic Research Key Project of Wuhan Municipal Bureau of Science and Technology(No.2020020601012218)the Fundamental Research Funds for the Central Universities(HUST COVID-19 Rapid Response Call No.2020kfyXGYJ040)National Natural Science Foundation of China(No.81802090).
文摘Objective:The ongoing COVID-19 pandemic warrants accelerated efforts to test vaccine candidates.To explore the influencing factors on vaccine-induced effects,antibody responses to an inactivated SARS-CoV-2 vaccine in healthy individuals who were not previously infected by COVID-19 were assessed.Methods:All subjects aged 18-60 years who did not have SARS-CoV-2 infection at the time of screening from June 19,2021,to July 02,2021,were approached for inclusion.All participants received two doses of inactivated SARS-CoV-2 vaccine.Serum IgM and IgG antibodies were detected using a commercial kit after the second dose of vaccination.A positive result was defined as 10 AU/mL or more and a negative result as less than 10 AU/mL.This retrospective study included 97 infection-naive individuals(mean age 35.6 years;37.1%male,62.9%female).Results:The seropositive rates of IgM and IgG antibody responses elicited after the second dose of inactivated SARS-CoV-2 vaccine were 3.1%and 74.2%,respectively.IgG antibody levels were significantly higher than IgM levels(P<0.0001).Sex had no effect on IgM and IgG antibody response after the second dose.The mean anti-IgG level in older persons(≥42 years)was significantly lower than that of younger recipients.There was a significantly lower antibody level at>42 days compared to that at 0-20 days(P<0.05)and 21-31 days(P<0.05)after the second dose.Conclusion:IgG antibody response could be induced by inactivated SARS-CoV-2 vaccine in healthy individuals(>18 years),which can be influenced by age and detection time after the second dose of vaccination.
基金partially supported by the National Key R&D Program of China Grant(Grant No.2016YFA0500600)the National Natural Science Foundation of China(Grant Nos.31970130,31600672,31900112,21907065,and 32000027)。
文摘Coronavirus disease 2019(COVID-19),which is caused by SARS-CoV-2,varies with regard to symptoms and mortality rates among populations.Humoral immunity plays critical roles in SARS-CoV-2 infection and recovery from COVID-19.However,differences in immune responses and clinical features among COVID-19 patients remain largely unknown.Here,we report a database for COVID-19-specific IgG/IgM immune responses and clinical parameters(named COVID-ONE-hi).COVID-ONE-hi is based on the data that contain the IgG/IgM responses to 24 full-length/truncated proteins corresponding to 20 of 28 known SARS-CoV-2 proteins and 199 spike protein peptides against 2360 serum samples collected from 783 COVID-19 patients.In addition,96 clinical parameters for the 2360 serum samples and basic information for the 783 patients are integrated into the database.Furthermore,COVID-ONE-hi provides a dashboard for defining samples and a one-click analysis pipeline for a single group or paired groups.A set of samples of interest is easily defined by adjusting the scale bars of a variety of parameters.After the“START”button is clicked,one can readily obtain a comprehensive analysis report for further interpretation.COVID-ONE-hi is freely available at www.COVID-ONE.cn.
基金supported by the National Natural Science Foundation Foundation of China(Grant Nos.61871196,61673186,and 61602190)the Natural Science Foundation of Fujian Province of China(2019J01082 and 2017J01110)the Promotion Program for Young and Middle-aged Teacher in Science and Technology Research of Huaqiao University(ZQN-YX601 and ZQN-710)。
文摘Photomosaic images are composite images composed of many small images called tiles.In its overall visual effect,a photomosaic image is similar to the target image,and photomosaics are also called“montage art”.Noisy blocks and the loss of local information are the major obstacles in most methods or programs that create photomosaic images.To solve these problems and generate a photomosaic image in this study,we propose a tile selection method based on error minimization.A photomosaic image can be generated by partitioning the target image in a rectangular pattern,selecting appropriate tile images,and then adding them with a weight coefficient.Based on the principles of montage art,the quality of the generated photomosaic image can be evaluated by both global and local error.Under the proposed framework,via an error function analysis,the results show that selecting a tile image using a global minimum distance minimizes both the global error and the local error simultaneously.Moreover,the weight coefficient of the image superposition can be used to adjust the ratio of the global and local errors.Finally,to verify the proposed method,we built a new photomosaic creation dataset during this study.The experimental results show that the proposed method achieves a low mean absolute error and that the generated photomosaic images have a more artistic effect than do the existing approaches.
基金supported by National Key Research and Development Program of China Grant(No.2016YFA0500600)Science and Technology Commission of Shanghai Municipality(No.19441911900)+1 种基金Interdisciplinary Program of Shanghai Jiao Tong University(No.YG2020YQ10)the National Natural Science Foundation of China(No.31900112,21907065,31970130,and 31670831).
文摘Serological tests play an essential role in monitoring and combating the COVID-19 pandemic.Recombinant spike protein(S protein),especially the S1 protein,is one of the major reagents used for serological tests.However,the high cost of S protein production and possible cross-reactivity with other human coronaviruses pose unavoidable challenges.By taking advantage of a peptide microarray with full spike protein coverage,we analyzed 2,434 sera from 858 COVID-19 patients,63 asymptomatic patients and 610 controls collected from multiple clinical centers.Based on the results,we identified several S protein-derived 12-mer peptides that have high diagnostic performance.In particular,for monitoring the IgG response,one peptide(aa 1148-1159 or S2-78)exhibited a sensitivity(95.5%,95%CI 93.7-96.9%)and specificity(96.7%,95%CI 94.8-98.0%)comparable to those of the S1 protein for the detection of both symptomatic and asymptomatic COVID-19 cases.Furthermore,the diagnostic performance of the S2-78(aa 1148-1159)IgG was successfully validated by ELISA in an independent sample cohort.A panel of four peptides,S1-93(aa 553-564),S1-97(aa 577-588),S1-101(aa 601-612)and S1-105(aa 625-636),that likely will avoid potential cross-reactivity with sera from patients infected by other coronaviruses was constructed.The peptides identified in this study may be applied independently or in combination with the S1 protein for accurate,affordable,and accessible COVID-19 diagnosis.
