Prognostic value of clinicopathological characteristics in patients with pancreatic cancer

Background： The purpose of this study was to analyze the effects of all clinical characteristics on the overall survival time, in order to provide a basis for determining the prognostic factor of patients with pancreatic cancer. Methods： A total of 103 pancreatic cancer patients were admitted to the Department of Radiotherapy and Chemotherapy of the Ruijin Hospital, Shanghai Jiaotong University School of Medicine, between January 2002 and December 2012. There were 68 men and 35 women; the median age was 62 years. Diagnoses of pancreatic cancer in all patients were confirmed by histopathology, cytology, or clinical diagnosis. The Kaplan-Meier method was performed to calculate the overall survival rate. The log-rank method was used to examine the univariate analysis. The Cox regression model was performed for multivariate analysis. Results： The median survival time was 293 days, the 1-, 2-, and 3-year survival rates were 27.18%, 5.83%, and 1.94%, respectively. Cox regression analysis revealed that age （P=0.015）, Karnofsky performance status （PS） （P=0.002）, surgical types （P〈0.001）, and platelet counts （P〈0.001） were independent prognostic factors affecting the overall survival of patients with pancreatic cancer. Conclusions＂ Pancreatic cancer had a poor prognosis, the general physical condition, age, the availability of radical surgery, and platelet counts were factors influencing the overall survival of patients with pancreatic cancer.

Decitabine induces IRF7-mediated immune responses in p53-mutated triple-negative breast cancer:a clinical and translational study

p53 is mutated in half of cancer cases.However,no p53-targeting drugs have been approved.Here,we reposition decitabine for triple-negative breast cancer(TNBC),a subtype with frequent p53 mutations and extremely poor prognosis.In a retrospective study on tissue microarrays with 132 TNBC cases,DNMT1 overexpression was associated with p53 mutations(P=0.037)and poor overall survival(OS)(P=0.010).In a prospective DEciTabinE and Carboplatin in TNBC(DETECT)trial(NCT03295552),decitabine with carboplatin produced an objective response rate(ORR)of 42%in 12 patients with stage IV TNBC.Among the 9 trialed patients with available TP53 sequencing results,the 6 patients with p53 mutations had higher ORR(3/6 vs.0/3)and better OS(16.0 vs.4.0 months)than the patients with wild-type p53.In a mechanistic study,isogenic TNBC cell lines harboring DETECT-derived p53 mutations exhibited higher DNMT1 expression and decitabine sensitivity than the cell line with wild-type p53.In the DETECT trial,decitabine induced strong immune responses featuring the striking upregulation of the innate immune player IRF7 in the p53-mutated TNBC cell line(upregulation by 16-fold)and the most responsive patient with TNBC.Our integrative studies reveal the potential of repurposing decitabine for the treatment of p53-mutated TNBC and suggest IRF7 as a potential biomarker for decitabine-based treatments.

手性晶体CoSi中拓扑费米弧的电荷不稳定性

拓扑边界态出现在拓扑非平庸态和平庸态之间的边界上,通常是无间隙的或被称为金属态.例如,拓扑绝缘体的表面态是无间隙的狄拉克态.这些金属拓扑边界态往往可以被近自由费米子很好的描述.如果拓扑边界态具有显著的电子-电子相互作用的行为,无间隙的边界态会转变为有间隙的有序态,例如密度波态或超导态,这在理论上是非常有趣的,但目前还缺少相关的实验证据.本文报道了在Co Si(001)表面观察到了电子-电子相互作用驱动的、在拓扑边界态上形成的非公度电荷密度波(CDW). CDW的波矢随温度的变化而变化,这与拓扑表面费米弧随温度的演化相吻合. CDW相的取向由费米弧的手性决定,这暗示了CDW与费米弧之间存在直接的联系.该发现将促进在拓扑材料边界上寻找更多相互作用驱动的有序态,例如超导和磁性.

Soil legacy effects and plant-soil feedback contribution to secondary succession processes

Secondary succession is the process by which a community develops into a climax community over time.However,knowledge on the mechanisms,relating to soil legacy effects(soil chemistry and enzyme activity)and plant-soil feedback(PSF),driving community succession remains limited.In this work,we examined the PSF associated with three succession stage species through a 2-year greenhouse experiment.Setaria viridis,Stipa bungeana,and Bothriochloa ischemum were selected to represent dominant and representative early-,mid-,and late-successional stage species,respectively,of semiarid grasslands on the Loess Plateau.In response to the different soil origin,the shoot biomass of early-,mid-,and late-species were all higher when grown in their own soil than in other species’soils,which indicated that the PSF of three species were positive.Over two growth periods,the early-species experienced a negative PSF,but the mid-and late-species experienced negative,neutral and positive PSF in the soil of early-,mid-and late-species,respectively.Our study demonstrates that soil legacy effects and PSF have a significant impact on community succession processes.

Invasibility and recoverability of a plant community following invasion depend on its successional stages

Exotic species invasion represent important causes of harming the structure,function,and ecological environment in ecosystems.Yet,knowledge remains limited on the invasibility(invasion advantage of exotic species)and recoverability(recovery ability of native species)of a plant community following invasion depend on its successional stages.We selected three grasses of Setaria viridis,Artemisia gmelinii,and Bothriochloa ischemum representing early(E),middle(M),and late(L)successional species,respectively.Meanwhile,the grasses of Panicum virgatum was selected to represent exotic species(invasion species).Three types of soil were collected to treat the three E,M,and L successional species,and one type of soil was collected to treat the exotic species.We compared the performance of the three native plant species and one exotic species grown in their“own”and“other”soils in a 2-year greenhouse experiment.Our study showed that exotic species performed better in soils of E and M successional species than in the soil of L successional species.After exotic species removed,E and M successional species exhibited poor growth in the soil of exotic species,while that of L successional species performed poor in field exotic species soils,but performed better in soils disturbed by exotic species.Our study demonstrated that the invasibility and recoverability of native plant communities changed with vegetation succession.