Background Women who had delivered a macrosomic newborn will have a higher risk to deliver another macrosomia.We aimed to examine the recurrence risk of macrosomia in the subsequent pregnancy and the implications in l...Background Women who had delivered a macrosomic newborn will have a higher risk to deliver another macrosomia.We aimed to examine the recurrence risk of macrosomia in the subsequent pregnancy and the implications in long-term child health.Methods Data from the Collaborative Perinatal Project,a longitudinal birth cohort with 54,371 singleton births,were used.401 recurrent macrosomic infants (macro-macro) and 1327 normal weight babies with a macrosomia in the last pregnancy (macro-normal) were selected to explore risk factors for recurrent macrosomia.Furthermore,768 newly onset macrosomia with normal birthweight infant in previous pregnancies (normal-macro) were identified to examine long-term health effects of recurrent macrosomia.Results The recurrent rate of macrosomia was 23.2% [95% confidence interval (CI) 21.2%,25.2%].White race,higher pre-pregnant body mass index (BMI),more gestational weight gain,male infant and more prior macrosomic infants were significant risk factors for recurrent macrosomia.At 4 years of age,recurrent macrosomic infants had a higher BMI (16.7 vs.16.1 kg/m2,adjusted fβ:0.36,95% CI:0.12,0.60) and a higher risk of overweight and obesity (adjusted OR:1.56,95% CI:1.10,2.23) than infants with normal birthweight after a previous macrosomic sibling.There was no significant difference between recurrent macrosomia and newly onset macrosomia in child outcomes after adjustment for covariates.Conclusions Fetal macrosomia has a high recurrence rate in the following pregnancy.Higher maternal pre-pregnant BMI and gestational weight gain are still important risk factors for recurrence of macrosomia,which in turn increases the risk for childhood obesity.展开更多
Two new oplopane sesquiterpenes, gmelinin A（1） and gmelinin B（2）, were isolated from Artemisia gmelinii Web. ex Stechm. Their structures were established by spectroscopic techniques（mainly 1D and2 D NMR） and app...Two new oplopane sesquiterpenes, gmelinin A（1） and gmelinin B（2）, were isolated from Artemisia gmelinii Web. ex Stechm. Their structures were established by spectroscopic techniques（mainly 1D and2 D NMR） and application of the modified Mosher method.展开更多
Tip-enhanced infrared(IR)spectra and imaging have been widely used in cutting-edge studies for the in-depth understanding of the composition,structure,and function of interfaces at the nanoscale.However,molecular mono...Tip-enhanced infrared(IR)spectra and imaging have been widely used in cutting-edge studies for the in-depth understanding of the composition,structure,and function of interfaces at the nanoscale.However,molecular monolayer sensitivity has only been demonstrated at solid/gas interfaces.In an aqueous environment,reduced sensitivity limits the practical applications of tip-enhanced IR nanospectroscopy.Here,we present an approach to hypersensitive nanoscale IR spectra and imaging in an aqueous environment with a combination of photoinduced force(PiF)microscopy and resonant antennas.展开更多
文摘Background Women who had delivered a macrosomic newborn will have a higher risk to deliver another macrosomia.We aimed to examine the recurrence risk of macrosomia in the subsequent pregnancy and the implications in long-term child health.Methods Data from the Collaborative Perinatal Project,a longitudinal birth cohort with 54,371 singleton births,were used.401 recurrent macrosomic infants (macro-macro) and 1327 normal weight babies with a macrosomia in the last pregnancy (macro-normal) were selected to explore risk factors for recurrent macrosomia.Furthermore,768 newly onset macrosomia with normal birthweight infant in previous pregnancies (normal-macro) were identified to examine long-term health effects of recurrent macrosomia.Results The recurrent rate of macrosomia was 23.2% [95% confidence interval (CI) 21.2%,25.2%].White race,higher pre-pregnant body mass index (BMI),more gestational weight gain,male infant and more prior macrosomic infants were significant risk factors for recurrent macrosomia.At 4 years of age,recurrent macrosomic infants had a higher BMI (16.7 vs.16.1 kg/m2,adjusted fβ:0.36,95% CI:0.12,0.60) and a higher risk of overweight and obesity (adjusted OR:1.56,95% CI:1.10,2.23) than infants with normal birthweight after a previous macrosomic sibling.There was no significant difference between recurrent macrosomia and newly onset macrosomia in child outcomes after adjustment for covariates.Conclusions Fetal macrosomia has a high recurrence rate in the following pregnancy.Higher maternal pre-pregnant BMI and gestational weight gain are still important risk factors for recurrence of macrosomia,which in turn increases the risk for childhood obesity.
文摘Two new oplopane sesquiterpenes, gmelinin A（1） and gmelinin B（2）, were isolated from Artemisia gmelinii Web. ex Stechm. Their structures were established by spectroscopic techniques（mainly 1D and2 D NMR） and application of the modified Mosher method.
基金supported by grants from the National Key Research and Development Program of China(no.2017YFA0206500)the National Natural Science Foundation of China(no.21635004,22004069)+1 种基金the Excellent Research Program of Nanjing University(no.ZYJH004)the State Key Laboratory of Analytical Chemistry for Life Science(no.5431ZZXM2001).
文摘Tip-enhanced infrared(IR)spectra and imaging have been widely used in cutting-edge studies for the in-depth understanding of the composition,structure,and function of interfaces at the nanoscale.However,molecular monolayer sensitivity has only been demonstrated at solid/gas interfaces.In an aqueous environment,reduced sensitivity limits the practical applications of tip-enhanced IR nanospectroscopy.Here,we present an approach to hypersensitive nanoscale IR spectra and imaging in an aqueous environment with a combination of photoinduced force(PiF)microscopy and resonant antennas.
