Liver fibrosis is a wound-healing response following chronic liver injury caused by hepatitis virus infection,obesity,or excessive alcohol.It is a dynamic and reversible process characterized by the activation of hepa...Liver fibrosis is a wound-healing response following chronic liver injury caused by hepatitis virus infection,obesity,or excessive alcohol.It is a dynamic and reversible process characterized by the activation of hepatic stellate cells and excess accumulation of extracellular matrix.Advanced fibrosis could lead to cirrhosis and even liver cancer,which has become a significant health burden worldwide.Many studies have revealed that noncoding RNAs(ncRNAs),including microRNAs,long noncoding RNAs and circular RNAs,are involved in the pathogenesis and development of liver fibrosis by regulating signaling pathways including transforming growth factor-βpathway,phosphatidylinositol 3-kinase/protein kinase B pathway,and Wnt/β-catenin pathway.NcRNAs in serum or exosomes have been reported to tentatively applied in the diagnosis and staging of liver fibrosis and combined with elastography to improve the accuracy of diagnosis.NcRNAs mimics,ncRNAs in mesenchymal stem cell-derived exosomes,and lipid nanoparticles-encapsulated ncRNAs have become promising therapeutic approaches for the treatment of liver fibrosis.In this review,we update the latest knowledge on ncRNAs in the pathogenesis and progression of liver fibrosis,and discuss the potentials and challenges to use these ncRNAs for diagnosis,staging and treatment of liver fibrosis.All these will help us to develop a comprehensive understanding of the role of ncRNAs in liver fibrosis.展开更多
Using prospecting line profile map in combination with drilling and other information for 3D reconstruction of geological model is an important method of 3D geological modeling.?This paper?discusses the theory and imp...Using prospecting line profile map in combination with drilling and other information for 3D reconstruction of geological model is an important method of 3D geological modeling.?This paper?discusses the theory and implementation method of 2D prospecting line map into 3D prospecting line map and then into 3D model. The authors propose that it needs twice upgrading dimension to reconstruction 3D geology model from prospecting line profile map. The first upgrading dimension is to convert profile from 2D into 3D profile,?i.e.?the 2D points in the 2D profile map upgrading dimensional transformation to 3D points in a 3D profile. The second upgrading dimension is that transform 0D point 1D curve and 2D polygon feature into 1D curve, 2D surface and 3D solid feature. The paper reexamines contents and forms in prospecting line map from the two different viewpoints of geology and geographic information science. The process of 3D geology modeling from 2D prospecting map is summarized as follows. Firstly, profile is divided into several sections by beginning, end and drill point of the prospecting line. Next, a 3D folded upright profile frame is built by 2D folded prospecting line on the plan map. Then, 2D points of features on 2D profile are converted into 3D points on 3D profile section by section. And then, adding switch control points for the long line crossover two segments. Lastly, 1D curve features are upgraded to 2D surface.展开更多
To the Editor： Inflammatory myofibroblastic tumor of the urinary bladder （IMTUB） is rare clinically. To the best of our knowledge, few Asian cases with IMTUB have been reported currently. IMTUB olien mimics soli-ti...To the Editor： Inflammatory myofibroblastic tumor of the urinary bladder （IMTUB） is rare clinically. To the best of our knowledge, few Asian cases with IMTUB have been reported currently. IMTUB olien mimics soli-tissue sarcoma both clinically and radiologically, which is thereby often mistaken for sarcoma. Typically, surgical resection is its major treatment, but the role of adjuvant or palliative radiochemotherapy remains unclear so far. Herein, this case reported a Chinese female with IMTUB.展开更多
基金Supported by Science and Technology Innovation Talent Project of Sichuan Province,No.2022JDRC0047the Central Government-directed Special Funds for Local Science and Technology Development Project,No.2021ZYD0085+1 种基金Natural Science Foundation of China,No.82102383Qin Chuangyuan Recruited High-level Innovation and Entrepreneurship Talents Project of Science and Technology Department of Shaanxi Province,No.QCYRCXM-2022-56.
文摘Liver fibrosis is a wound-healing response following chronic liver injury caused by hepatitis virus infection,obesity,or excessive alcohol.It is a dynamic and reversible process characterized by the activation of hepatic stellate cells and excess accumulation of extracellular matrix.Advanced fibrosis could lead to cirrhosis and even liver cancer,which has become a significant health burden worldwide.Many studies have revealed that noncoding RNAs(ncRNAs),including microRNAs,long noncoding RNAs and circular RNAs,are involved in the pathogenesis and development of liver fibrosis by regulating signaling pathways including transforming growth factor-βpathway,phosphatidylinositol 3-kinase/protein kinase B pathway,and Wnt/β-catenin pathway.NcRNAs in serum or exosomes have been reported to tentatively applied in the diagnosis and staging of liver fibrosis and combined with elastography to improve the accuracy of diagnosis.NcRNAs mimics,ncRNAs in mesenchymal stem cell-derived exosomes,and lipid nanoparticles-encapsulated ncRNAs have become promising therapeutic approaches for the treatment of liver fibrosis.In this review,we update the latest knowledge on ncRNAs in the pathogenesis and progression of liver fibrosis,and discuss the potentials and challenges to use these ncRNAs for diagnosis,staging and treatment of liver fibrosis.All these will help us to develop a comprehensive understanding of the role of ncRNAs in liver fibrosis.
文摘Using prospecting line profile map in combination with drilling and other information for 3D reconstruction of geological model is an important method of 3D geological modeling.?This paper?discusses the theory and implementation method of 2D prospecting line map into 3D prospecting line map and then into 3D model. The authors propose that it needs twice upgrading dimension to reconstruction 3D geology model from prospecting line profile map. The first upgrading dimension is to convert profile from 2D into 3D profile,?i.e.?the 2D points in the 2D profile map upgrading dimensional transformation to 3D points in a 3D profile. The second upgrading dimension is that transform 0D point 1D curve and 2D polygon feature into 1D curve, 2D surface and 3D solid feature. The paper reexamines contents and forms in prospecting line map from the two different viewpoints of geology and geographic information science. The process of 3D geology modeling from 2D prospecting map is summarized as follows. Firstly, profile is divided into several sections by beginning, end and drill point of the prospecting line. Next, a 3D folded upright profile frame is built by 2D folded prospecting line on the plan map. Then, 2D points of features on 2D profile are converted into 3D points on 3D profile section by section. And then, adding switch control points for the long line crossover two segments. Lastly, 1D curve features are upgraded to 2D surface.
文摘To the Editor： Inflammatory myofibroblastic tumor of the urinary bladder （IMTUB） is rare clinically. To the best of our knowledge, few Asian cases with IMTUB have been reported currently. IMTUB olien mimics soli-tissue sarcoma both clinically and radiologically, which is thereby often mistaken for sarcoma. Typically, surgical resection is its major treatment, but the role of adjuvant or palliative radiochemotherapy remains unclear so far. Herein, this case reported a Chinese female with IMTUB.
