Postoperative hypoxemia for patients undergoing Stanford type A aortic dissection

Clinically,it is widely recognized that surgical treatment is the preferred and reliable option for Stanford type A aortic dissection.Stanford type A aortic dissection is an emergent and serious cardiovascular disease characterized with an acute onset,poor prognosis,and high mortality.However,the incidences of postoperative complications are relatively higher due to the complexity of the disease and its intricate procedure.It has been considered that hypoxemia,one of the most common postoperative complications,plays an important role in having a worse clinical prognosis.Therefore,the effective intervention of postoperative hypoxemia is significant for the improved prognosis of patients with Stanford type A aortic dissection.

右美托咪定对小儿先天性心脏病术后急性肾功能损伤的预防效应

目的了解右美托咪定对小儿先天性心脏病术后急性肾功能损伤的预防效应。方法 30例确诊房间隔或室间隔缺损的患儿参与研究。患儿随机分别接受生理盐水(对照组,n = 15)和右美托咪定(试药组,n = 15)给药处理,给药时间从麻醉诱导至体外循环结束。分别于术前(T0),麻醉诱导后10 min(T1),体外循环结束后5 min(T2),T2点后2 h(T3),术后第1天(POD1)和术后第2天(POD2)测定血肌酐水平(SCr)并计算肾小球滤过率估值(eGFR)。急性肾功能损伤(AKI)定义为SCr绝对值增加超过3 mg/L或是上升幅度超过50%。结果对比对照组,试药组中围术期AKI发病率显著降低(P < 0.05)。T2和T3点测定对照组中eGFR水平较试药组显著降低(P < 0.05)。结论术中给药右美托咪定有助于降低AKI的发病率并有效防止体外循环结束后eGFR水平的下降。