Objective To explore the role of serum fibrotic indices including hyaluronic acid (HA), procollagen type III NH_ 2-terminal peptide (PCIIIP), and laminin (LN) in assessing the severity of myocardial fibrosis in chroni...Objective To explore the role of serum fibrotic indices including hyaluronic acid (HA), procollagen type III NH_ 2-terminal peptide (PCIIIP), and laminin (LN) in assessing the severity of myocardial fibrosis in chronic congestive heart failure (CHF).Methods Serum levels of HA, PCIIIP, and LN in 39 patients with CHF[14 with New York Heart Association (NYHA) functional class II, 21 with class III, 4 with class IV]and in 46 patients with NYHA functional class I were assessed by radioimmunoassay.Results The serum concentrations of HA, PCIIIP, and LN were 359.75±84.59 μg/L, 77.88±24.67 μg/L, 86.73±23.90 μg/L in CHF group, and 211.60±54.80 μg/L, 64.82±23.99 μg/L, 82.26±23.98 μg/L in NYHA functional class I group, respectively. The HA level was significantly higher in CHF patients as compared with NYHA functional class I group (P<0.05). However, no difference was found in the levels of PCIIIP and LN between CHF group and NYHA functional class I group. The serum HA concentration was negatively correlated with left ventricular ejection fraction (r=-0.71, P<0.05).Conclusion Serum HA level may act as an indicator for myocardial fibrosis.展开更多
Additively manufactured Ti-6Al-4V(TC4)parts have been successfully employed as artificial implants in dental and orthopedic surgery due to their excellent mechanical properties.However,the suboptimal corrosion resista...Additively manufactured Ti-6Al-4V(TC4)parts have been successfully employed as artificial implants in dental and orthopedic surgery due to their excellent mechanical properties.However,the suboptimal corrosion resistance limits their applications.The surface characterization and corrosion behavior of micro-arc oxidation(MAO)treated TC4 alloy prepared by selective electron beam melting(SEBM)and selective laser melting(SLM)technologies were compared.The corrosion resistance mechanism of SLM-MAO and SEBM-MAO was clarified through the analysis of the microstructure evolution,surface morphology,and electrochemical experiments.The results show that the anatase-type TiO_(2) is partially transformed into the slankite phase after MAO treatment.The surface roughness of SEBM sample was reduced by MAO coating,while the surface roughness of SLM sample increased after MAO,which is related to the difference between the microstructure of the deposited samples caused by different additive manufacturing technologies.When MAO time was 15 min,SLM-MAO and SEBM-MAO coating displayed the best and the worst corrosion resistance,respectively.展开更多
Two-dimensional(2D)ferromagnetic and ferroelectric materials attract unprecedented attention due to the spontaneous-symmetry-breaking induced novel properties and multifarious potential applications.Here we systematic...Two-dimensional(2D)ferromagnetic and ferroelectric materials attract unprecedented attention due to the spontaneous-symmetry-breaking induced novel properties and multifarious potential applications.Here we systematically investigate a large family(148)of 2D MGeX3(M=metal elements,X=O/S/Se/Te)by means of the high-throughput first-principles calculations,and focus on their possible ferroic properties including ferromagnetism,ferroelectricity,and ferroelasticity.We discover eight stable 2D ferromagnets including five semiconductors and three half-metals,212D antiferromagnets,and 11 stable 2D ferroelectric semiconductors including two multiferroic materials.Particularly,MnGeSe3 and MnGeTe3 are predicted to be room-temperature 2D ferromagnetic half metals with Tc of 490 and 308 K,respectively.It is probably for the first time that ferroelectricity is uncovered in 2D MGeX3 family,which derives from the spontaneous symmetry breaking induced by unexpected displacements of Ge-Ge atomic pairs,and we also reveal that the electric polarizations are in proportion to the ratio of electronegativity of X and M atoms,and IVB group metal elements are highly favored for 2D ferroelectricity.Magnetic tunnel junction and water-splitting photocatalyst based on 2D ferroic MGeX3 are proposed as examples of wide potential applications.The atlas of ferroicity in 2D MGeX3 materials will spur great interest in experimental studies and would lead to diverse applications.展开更多
钾离子电池在大规模储能方面具有广阔的前景.然而,缺乏合适的正极材料限制了其实际应用.此外,为钾离子电池合理设计先进的正极材料仍然面临挑战.本工作中,通过密度泛函理论计算,我们发现层状过渡金属氧化物中Fe-O键稳定性高于Co-O键.此...钾离子电池在大规模储能方面具有广阔的前景.然而,缺乏合适的正极材料限制了其实际应用.此外,为钾离子电池合理设计先进的正极材料仍然面临挑战.本工作中,通过密度泛函理论计算,我们发现层状过渡金属氧化物中Fe-O键稳定性高于Co-O键.此外,Fe基层状氧化物中的钾离子迁移具有明显低于Co基氧化物的活化能垒.基于这一理论预测,我们成功合成了一种低成本的K_(0.45)Ni_(0.1)Fe_(0.1)Mn_(0.8)O_(2)正极,该正极显示出优异的结构稳定性和储钾性能,包括较长的循环寿命和高倍率性能.此外,所设计的K_(0.45)Ni_(0.1)Fe_(0.1)Mn_(0.8)O_(2)正极具有良好的全电池性能,放电容量约为75 mA h g^(-1),100次循环后容量保持率约为80%.在层状氧化物正极中,Fe比高成本Co具有更好的结构稳定性和钾离子扩散能力,这一发现为低成本和高性能钾离子电池层状正极的设计提供了新的思路.这项工作突出了以理论为指导的实验在筛选有前景的电池材料方面的可行性.展开更多
文摘Objective To explore the role of serum fibrotic indices including hyaluronic acid (HA), procollagen type III NH_ 2-terminal peptide (PCIIIP), and laminin (LN) in assessing the severity of myocardial fibrosis in chronic congestive heart failure (CHF).Methods Serum levels of HA, PCIIIP, and LN in 39 patients with CHF[14 with New York Heart Association (NYHA) functional class II, 21 with class III, 4 with class IV]and in 46 patients with NYHA functional class I were assessed by radioimmunoassay.Results The serum concentrations of HA, PCIIIP, and LN were 359.75±84.59 μg/L, 77.88±24.67 μg/L, 86.73±23.90 μg/L in CHF group, and 211.60±54.80 μg/L, 64.82±23.99 μg/L, 82.26±23.98 μg/L in NYHA functional class I group, respectively. The HA level was significantly higher in CHF patients as compared with NYHA functional class I group (P<0.05). However, no difference was found in the levels of PCIIIP and LN between CHF group and NYHA functional class I group. The serum HA concentration was negatively correlated with left ventricular ejection fraction (r=-0.71, P<0.05).Conclusion Serum HA level may act as an indicator for myocardial fibrosis.
基金funded by the National Natural Science Foundation of China (Nos.51671152 and 51874225)the Industrialization Project of Shaanxi Education Department (18JCO19)+1 种基金the Key Research and Development Program of Shaanxi Province (2020ZDLGY13-10)the Science and Technology Plan Project of Xi'an (2020KJRC0048).
文摘Additively manufactured Ti-6Al-4V(TC4)parts have been successfully employed as artificial implants in dental and orthopedic surgery due to their excellent mechanical properties.However,the suboptimal corrosion resistance limits their applications.The surface characterization and corrosion behavior of micro-arc oxidation(MAO)treated TC4 alloy prepared by selective electron beam melting(SEBM)and selective laser melting(SLM)technologies were compared.The corrosion resistance mechanism of SLM-MAO and SEBM-MAO was clarified through the analysis of the microstructure evolution,surface morphology,and electrochemical experiments.The results show that the anatase-type TiO_(2) is partially transformed into the slankite phase after MAO treatment.The surface roughness of SEBM sample was reduced by MAO coating,while the surface roughness of SLM sample increased after MAO,which is related to the difference between the microstructure of the deposited samples caused by different additive manufacturing technologies.When MAO time was 15 min,SLM-MAO and SEBM-MAO coating displayed the best and the worst corrosion resistance,respectively.
基金the National Key R&D Program of China(2018YFA0305800)the Strategic Priority Research Program of Chinese Academy of Sciences(XDB28000000)+2 种基金the National Natural Science Foundation of China(11834014)Beijing Municipal Science and Technology Commission(Z191100007219013)University of Chinese Academy of Sciences。
基金This work is supported in part by the National Key R&D Program of China(No.2018YFA0305800)the Strategic Priority Research Program of Chinese Academy of Sciences(No.XDB28000000)+2 种基金the National Natural Science Foundation of China(No.11834014)the Beijing Municipal Science and Technology Commission(No.Z118100004218001)the fundamental research funds for the central universities,and University of Chinese Academy of Sciences.
文摘Two-dimensional(2D)ferromagnetic and ferroelectric materials attract unprecedented attention due to the spontaneous-symmetry-breaking induced novel properties and multifarious potential applications.Here we systematically investigate a large family(148)of 2D MGeX3(M=metal elements,X=O/S/Se/Te)by means of the high-throughput first-principles calculations,and focus on their possible ferroic properties including ferromagnetism,ferroelectricity,and ferroelasticity.We discover eight stable 2D ferromagnets including five semiconductors and three half-metals,212D antiferromagnets,and 11 stable 2D ferroelectric semiconductors including two multiferroic materials.Particularly,MnGeSe3 and MnGeTe3 are predicted to be room-temperature 2D ferromagnetic half metals with Tc of 490 and 308 K,respectively.It is probably for the first time that ferroelectricity is uncovered in 2D MGeX3 family,which derives from the spontaneous symmetry breaking induced by unexpected displacements of Ge-Ge atomic pairs,and we also reveal that the electric polarizations are in proportion to the ratio of electronegativity of X and M atoms,and IVB group metal elements are highly favored for 2D ferroelectricity.Magnetic tunnel junction and water-splitting photocatalyst based on 2D ferroic MGeX3 are proposed as examples of wide potential applications.The atlas of ferroicity in 2D MGeX3 materials will spur great interest in experimental studies and would lead to diverse applications.
基金supported by the Fundamental Research Funds for the Central Universities and the Scientific Instrument Developing Project of the Chinese Academy of Sciences(ZDKYYQ20170001)。
文摘钾离子电池在大规模储能方面具有广阔的前景.然而,缺乏合适的正极材料限制了其实际应用.此外,为钾离子电池合理设计先进的正极材料仍然面临挑战.本工作中,通过密度泛函理论计算,我们发现层状过渡金属氧化物中Fe-O键稳定性高于Co-O键.此外,Fe基层状氧化物中的钾离子迁移具有明显低于Co基氧化物的活化能垒.基于这一理论预测,我们成功合成了一种低成本的K_(0.45)Ni_(0.1)Fe_(0.1)Mn_(0.8)O_(2)正极,该正极显示出优异的结构稳定性和储钾性能,包括较长的循环寿命和高倍率性能.此外,所设计的K_(0.45)Ni_(0.1)Fe_(0.1)Mn_(0.8)O_(2)正极具有良好的全电池性能,放电容量约为75 mA h g^(-1),100次循环后容量保持率约为80%.在层状氧化物正极中,Fe比高成本Co具有更好的结构稳定性和钾离子扩散能力,这一发现为低成本和高性能钾离子电池层状正极的设计提供了新的思路.这项工作突出了以理论为指导的实验在筛选有前景的电池材料方面的可行性.
