血糖控制达标2型糖尿病患者发生糖尿病视网膜病变的影响因素

目的:探究血糖控制达标2型糖尿病(T2DM)患者发生糖尿病视网膜病变(DR)后血清视黄醇结合蛋白4(RBP4)、炎症指标中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)水平及影响患者发生DR的因素。方法:回顾性分析2017-02/2020-02我院收治的142例血糖控制达标的T2DM患者的临床资料,根据眼底造影检查结果将患者分为眼底正常组(N组,74例)、非增殖期糖尿病视网膜病变组(NPDR组,36例)和增殖期糖尿病视网膜病变组(PDR组,32例)。比较三组患者的一般资料和血液检查指标;多因素Logistic回归分析影响患者发生DR的因素;构建预测患者发生DR的列线图预测模型并评价其预测效能。结果:PDR组患者的DM病程、血清生长激素(GH)、胰岛素样生长因子-Ⅰ(IGF-Ⅰ)、低密度脂蛋白胆固醇(LDL-C)、尿微量白蛋白(UA)、视黄醇结合蛋白4(RBP4)水平、NLR、PLR明显高于N组和NPDR组,C肽(C-P)、2h C-P明显低于N组和NPDR组(P<0.05);DM病程>12a、IGF-Ⅰ>145μg/L、C-P<0.75ng/mL、UA>245ng/mL、RBP4>54mg/L、NLR>1.8、PLR>110均是导致患者发生DR的危险因素;列线图模型预测的区分度和校准度较高,具有良好的预测效能。结论:除DM病程、IGF-Ⅰ、C-P、UA等常见的危险因素外,RBP4、NLR、PLR增加也是DR发生的危险因素,可能参与了DR的发生和发展。

Optimization of clear liquid fermentation condition for ethanol production from Canna edulis Kerl

In this paper, clear liquid fermentation condition for ethanol production from Canna edulis Kerl with orthogonal design was studied. We have studied five factors that influenced clear liquid fermentation condition for ethanol production from Canna edulis Kerl by the single-factor test. The five factors were α-amylase amount, glu-coamylase amount, pH, nitrogen and auxiliary materials amount. Selected the best amounts of α-amylase, glucoamylase, pH, nitrogen source and auxiliary materials by means of the singe- factors test. And then, we used the Orthogonal test to optimize the fermentation process. The study showed that the best fermentation condi-tions were α-amylase amount 7 u/g C.eduli, glu-coamylase amount 145u/g C. edulis, pH 4.4 and the amount of urea 0.08%, 1% of rice bran as auxiliary materials. The rate of alcohol which was produced by the best fermentation conditions is 21.5% that increased by 1.3% than the rate of alcohol by the single-factor test.