Trace elements in magmatic and hydrothermal quartz:Implications on the genesis of the Xingluokeng Tungsten Deposit,South China

The Xingluokeng deposit is the largest gran-ite-related tungsten deposit within the Wuyi metallogenic belt in South China.The Xingluokeng intrusion primarily consists of porphyritic biotite granite,biotite granite,andfine-grained granite.The deposit is represented by veinlet-disseminated mineralization with K-feldspathization and biotitization,alongside quartz-vein mineralization with gre-isenization and sericitization.This study investigates in-situ analyses of quartz compositions from both the intrusion and hydrothermal veinlets and veins.Trace element correlations indicate that trivalent Al^(3+)and Fe^(3+)replace Si^(4+)within the quartz lattice,with monovalent cations(such as Li^(+),Na^(+),and K^(+))primarily serving as charge compensators.Low Ge/Al ratios(<0.013)of quartz from granites suggest a mag-matic origin.The low Al/Ti and Ge/Ti ratios,accompanied by high Ti contents in quartz,suggest that the porphyritic biotite granite and biotite granite are characterized by rela-tively low levels of differentiation and high crystallization temperatures.In contrast,thefine-grained granite exhibits a higher degree of fractionation,lower crystallization tem-peratures,and a closer association with tungsten miner-alization.Ti contents in quartz from quartz veins indicate Qz-Ⅰformed at temperatures above 400°C,while Qz-Ⅱto Qz-Ⅴformed at temperatures below 350°C.Variations in different generations of quartz,as indicated by Al content and(Al+Fe)/(Li+Na+K)ratio,suggest that Qz-Ⅰprecipi-tated from a less acidicfluid with a stable pH,whereas Qz-Ⅱto Qz-Ⅴoriginated from a more acidicfluid with notable pH variations.Consequently,alkaline alteration and acidic alteration supplied the essential Ca and Fe for the precipita-tion of scheelite and wolframite,respectively,highlighting a critical mechanism in tungsten mineralization at the Xin-gluokeng deposit.

Mediating role of social support in dysphoria,despondency,and quality of life in patients undergoing maintenance hemodialysis

BACKGROUND Dysphoria and despondency are prevalent psychological issues in patients undergoing Maintenance Hemodialysis(MHD)that significantly affect their quality of life(QOL).High levels of social support can significantly improve the physical and mental well-being of patients undergoing MHD.Currently,there is limited research on how social support mediates the relationship between dysphoria,despondency,and overall QOL in patients undergoing MHD.It is imperative to investigate this mediating effect to mitigate dysphoria and despondency in patients undergoing MHD,ultimately enhancing their overall QOL.AIM To investigate the mediating role of social support in relationships between dysphoria,despondency,and QOL among patients undergoing MHD.METHODS Participants comprised 289 patients undergoing MHD,who were selected using a random sampling approach.The Social Support Rating Scale,Self-Rating Anxiety Scale,Self-Rating Depression Scale,and QOL Scale were administered.Correlation analysis was performed to examine the associations between social support,dysphoria,despondency,and QOL in patients undergoing MHD.To assess the mediating impact of social support on dysphoria,despondency,and QOL in patients undergoing MHD,a bootstrap method was applied.RESULTS Significant correlations among social support,dysphoria,despondency,and quality in patients undergoing MHD were observed(all P<0.01).Dysphoria and despondency negatively correlated with social support and QOL(P<0.01).Dysphoria and despondency had negative predictive impacts on the QOL of patients undergoing MHD(P<0.05).The direct effect of dysphoria on QOL was statistically significant(P<0.05).Social support mediated the relationship between dysphoria and QOL,and this mediating effect was significant(P<0.05).Similarly,the direct effect of despondency on QOL was significant(P<0.05).Moreover,social support played a mediating role between despondency and QOL,with a significant mediating effect(P<0.05).CONCLUSION These findings suggest that social support plays a significant mediating role in the relationship between dysphoria,despondency,and QOL in patients undergoing MHD.

内镜下黏膜切开治疗食管巨大血肿1例

1981年GIRDWOOD等[1]首次报道了食管壁内血肿。随着阿司匹林等抗凝药物的广泛应用,近年来关于食管壁内血肿的报道也逐渐增多。本例患者为食管活检引起食管巨大血肿,经内镜下切开引流,缩短了恢复时间,为临床提供一个可选择的治疗手段。临沂市人民医院2018年7月12日收治1例食管壁内血肿患者,治疗效果较好。

Efficacy and safety of gemcitabine-based chemotherapies in biliary tract cancer:A meta-analysis

AIM:To investigate the efficacy and safety of gemcitabine(Gem)-based combination chemotherapies for the treatment of advanced biliary tract cancer.METHODS:Clinical trials were identified by searching scientific literature databases(Pub Med,EMBASE and the Cochrane Library)for studies published between1975 and 2013.Two reviewers independently evaluated the relevant studies and manually searched references from these reports to locate additional eligible studies.The disease response and control rates,progressionfree and overall survivals,and the grade 3-4 toxicities were evaluated by a meta-analysis.Odds-ratios(ORs)of the disease response and control rates and grade3-4 toxicities,and the mean difference(MD)of both progression-free and overall survivals were calculated and used for statistical analysis.RESULTS:Seven randomized trials with a total of 858patients were selected and included in the final analysis.The studies were divided into subgroups based on the chemotherapy regimens,including Gem-based and non-Gem-based chemotherapies.The overall analyses revealed that the patients treated with Gem-based combination chemotherapy had significantly higher disease response rates[OR=1.69,95%confidence interval(CI):1.17-2.43;P=0.01],a longer progressionfree survival(MD=1.95,95%CI:0.90-3.00;P=0.00)and a longer overall survival(MD=1.85,95%CI:0.26-3.44;P=0.02).A higher incidence of grade 3-4hematological toxicities,including leukopenia(OR=2.98,95%CI:1.44-6.20;P=0.00),anemia(OR=2.96,95%CI:1.79-4.92;P=0.00)and neutropenia(OR=2.80,95%CI:1.39-5.64;P=0.00)was found in the Gem-based combination chemotherapy group compared with the Gem monotherapy and non-Gem-based chemotherapy groups.CONCLUSION:Gem-based combination chemotherapy is a potential first-line treatment for advanced biliary tract cancer as a result of improved survival,though with additional toxicity.

Traditional Chinese medicine of Salvia miltiorrhiza Bunge: a review of phytochemistry, pharmacology and pharmacokinetics

Salvia miltiorrhiza Bunge,known as red sage or Danshen,is commonly applied in Chinese herbal therapeutics for various biological effects.In 25-220 C.E.,the earliest Chinese Materia Medica referred to as Shengong’s Classic of Materia Medica(Eastern Han Dynasty of China,200 C.E.)initially documented Salvia miltiorrhiza Bunge.Currently,Salvia miltiorrhiza Bunge is one of the most frequently prescribed traditional Chinese medicines in clinics for antidiabetic,antianxiety,antihypertensive,antidepressant,antilipidemic,antiarrhythmic,and anticancer effects.Undoubtedly,it is best known for improving and promoting blood circulation;thus,its recommendation for use in cardiovascular disorders.Regarding this article,important information was sourced both manually and electronically using patent compendium and databases,including Google Scholar,herbal plant monographs,Hindawi,PubMed,Embase,CNKI,pharmacopoeias,Springer,etc.Well-concise details and discussions on the botany,traditional medicinal uses,chemical constituents-phytochemistry,pharmacokinetics,pharmacology,and toxicology information are presented.In perspective,understanding the comprehensive information of the above-stated fields with regards to Salvia miltiorrhiza Bunge would yield an additional positive knowledge on areas that need urgent attention and identify gaps in research and safety for future consideration.

硬膜外相关产时发热对产妇炎症应激反应、母婴结局的影响

目的探讨硬膜外相关产时发热对产妇炎症应激反应、母婴结局的影响。方法回顾性分析2021年4月—2022年3月于芜湖市第一人民医院产科接受椎管内硬膜外分娩镇痛的150例产妇临床资料。按镇痛后是否发热分为对照组和发热组,分别有120例和30例。比较两组基本临床资料、分娩镇痛期间宫缩情况、炎症因子、应激反应及围产期母婴结局。结果两组产妇年龄、孕周、体质量指数、孕次、产次、镇痛前体温、镇痛时间比较,差异无统计学意义(P>0.05)。两组产妇宫口开2 cm时的宫缩间隔时间、宫缩持续时间比较,差异无统计学意义(P>0.05)。发热组产妇宫口开至4 cm、宫口开全时的宫缩间隔时间、宫缩持续时间长于对照组(P<0.05)。两组产妇宫口开2 cm时的血清白细胞介素1β(IL-1β)、IL-6、超敏C反应蛋白(hs-CRP)水平比较,差异无统计学意义(P>0.05)。发热组产妇宫口开全时的血清IL-1β、IL-6、hs-CRP水平高于对照组(P<0.05)。两组产妇宫口开2 cm时的血清皮质醇(Cor)、血管紧张素Ⅱ(AngⅡ)、去甲肾上腺素(NE)水平比较,差异无统计学意义(P>0.05)。发热组产妇宫口开全时的血清Cor、AngⅡ、NE水平高于对照组(P<0.05)。发热组抗生素使用率、胎儿宫内窘迫发生率、中转剖宫产率高于对照组,自然分娩率低于对照组。两组产妇产钳助产率比较,差异无统计学意义(P>0.05)。发热组新生儿并发症总发生率高于对照组(P<0.05)。结论硬膜外相关产时发热未造成产妇宫缩减弱,但会增加产妇炎症应激反应,降低自然分娩率,抗生素使用量增加,增加新生儿并发症发生风险。

Factors influencing physical property evolution in sandstone mechanical compaction:the evidence from diagenetic simulation experiments

In order to analyze the factors influencing sandstone mechanical compaction and its physical property evolution during compaction processes, simulation exper- iments on sandstone mechanical compaction were carried out with a self-designed diagenetic simulation system. The experimental materials were modem sediments from dif- ferent sources, and the experiments were conducted under high temperature and high pressure. Results of the exper- iments show a binary function relation between primary porosity and mean size as well as sorting. With increasing overburden pressure during mechanical compaction, the evolution of porosity and permeability can be divided into rapid compaction at an early stage and slow compaction at a late stage, and the dividing pressure value of the two stages is about 12 MPa and the corresponding depth is about 600 m. In the slow compaction stage, there is a good exponential relationship between porosity and overburden pressure, while a good power function relationship exists between permeability and overburden pressure. There is also a good exponential relationship between porosity and permeability. The influence of particle size on sandstone mechanical compaction is mainly reflected in the slowcompaction stage, and the influence of sorting is mainly reflected in the rapid compaction stage. Abnormally high pressure effectively inhibits sandstone mechanical com- paction, and its control on sandstone mechanical com- paction is stronger than that of particle size and sorting. The influence of burial time on sandstone mechanical compaction is mainly in the slow compaction stage, and the porosity reduction caused by compaction is mainly con- trolled by average particle size.

Cryoballoon pulmonary vein isolation and left atrial appendage occlusion prior to atrial septal defect closure: A case report

BACKGROUND In patients who suffer from both atrial fibrillation(AF)and atrial septal defect(ASD),cryoballoon pulmonary vein isolation(PVI),sequential left atrial appendage(LAA)occlusion and ASD closure could be a strategy for effective prevention of stroke and right heart failure.CASE SUMMARY A 65-year-old man was admitted to our institution due to recurrent episodes of palpitations and shortness of breath for 2 years,which had been worsening over the last 48 h.He had a history of AF,ASD,coronary heart disease with stent implantation and diabetes.Physical and laboratory examinations showed no abnormalities.The score of CHA2DS2VASc was 3,and HAS-BLED was 1.Echocardiography revealed a 25-mm secundum ASD.Pulmonary vein(PV)and LAA anatomy were assessed by cardiac computed tomography.PV mapping with 10-pole Lasso catheter was performed following ablation of all four PVs with complete PVI.Following the cryoballoon PVI,the patient underwent LAA occlusion under transesophageal echocardiographic monitoring.Lastly,a 34-mm JIYI ASD occlude device was implanted.A follow-up transesophageal echocardiography at 3 mo showed proper position of both devices and neither thrombi nor leakage was found.CONCLUSION Sequential cryoballoon PVI and LAA occlusion prior to ASD closure can be performed safely in AF patients with ASD.

Selective photosynthesis of imines from biomass-derived aldehydes over Ni/TiO_(2)

Photocatalytic reductive amination of biomass-derived aldehydes is a desirable way to selectively upgrade biomass into value-added nitrogen-containing chemicals under mild conditions.However,it is challenging to produce imines in high selectivity because of the undesirable side reactions caused by the activity of functional groups.Here,we demonstrate the highly reactive and selective production of imines from biomass derived aldehydes via the photocatalytic reductive amination,using a defective TiO_(2)supported nickel catalyst.The employment of methanol as the hydrogen donor and ammonia solution as the nitrogen source avoids the use of high-pressure H_(2)and expensive amines,rendering the current catalytic process safe,economical,and environmentally friendly.In depth investigations attribute the improved separation and transfer of photogenerated charge carriers to the presence of oxygen vacancies and decorated Ni nanoparticles,thereby accelerating the production of imines from benzaldehyde amination(conversion,95.8%;seleetivity,95.2%).Furthermore,the developed system could be easily translated to the photocatalytic conversions of various biomass derived aldehydes,which provided an example of a cost-effective and sustainable approach for the valorization of biomass derived feedstocks.

基于聚苯胺微胶囊的双重自修复防腐涂层

将乳液模板法、光聚合法以及苯胺的界面聚合相结合制备了负载亚麻籽油的聚苯胺微胶囊,并将微胶囊与水性环氧树脂涂层相结合来构筑了具有优异光热转化能力的双重自修复防腐涂层.当涂层受损后,微胶囊中的自修复剂亚麻籽油释放出来,对涂层进行修复;在近红外光(NIR)的照射下,聚苯胺可以有效地吸收光能并将其转化为热能,使涂层的温度高于其玻璃化转变温度,涂层破损处实现愈合.聚苯胺微胶囊的加入不仅赋予涂层优异的自修复能力,而且大大增强了其防腐能力.涂层的表面形貌、电化学与盐雾测试结果表明,聚苯胺微胶囊添加量为10%的涂层在NIR照射3 s内,可以实现快速闭合,恢复了其阻隔性能.此外,在300 h的盐雾测试后,涂层未产生任何的腐蚀产物,而纯涂层可以明显看到腐蚀现象.这种双重自修复防腐涂层的超快响应时间和高愈合效率以及优异的防腐性能具有潜在的应用价值.

Nonalcoholic Fatty Liver Disease: Dyslipidemia, Risk for Cardiovascular Complications, and Treatment Strategy

Studies have shown that nonalcoholic fatty liver disease (NAFLD) is strongly associated with several metabolic disorders and diseases,such as obesity,type 2 diabetes mellitus,and dyslipidemia.In NAFLD,dyslipidemia is manifested as increased serum triglyceride and low-density lipoprotein cholesterol levels and decreased high-density lipoprotein cholesterol levels,all of which are key risk factors for cardiovascular disease (CVD).CVD is a leading cause of mortality in NAFLD patients.Thus,implementation of an aggressive therapeutic strategy for dyslipidemia with hypolipidemic agents may mitigate the risk for CVD among NAFLD patients.Here,we provide a current review of literature regarding NAFLD,with particular emphasis on dyslipidemia and available treatment options.

Self-assembled aggregations in Coptidis Rhizoma decoction dynamically regulate intestinal tissue permeability through Peyer's patch-associated immunity

Objective:To investigate the dynamic regulation of self-assembled aggregations(SAA)in Coptidis Rhizoma decoction on the permeability of intestinal tissue and the mechanism underlying.Methods:The effects of SAA on berberine(Ber)absorption were respectively analyzed in an in situ intestinal perfusion model and in an Ussing Chamber jejunum model with or without Peyer’s patches(PPs).The expression levels of ZO-1,Occludin and Claudin-1 were detected by immunofluorescence to evaluate the tight junction(TJ)between intestinal epithelium cells.The expression levels of T-box-containing protein expressed in T cells,signal transducers and activators of tranion-6,retinoic acid receptor-related orphan receptor ct and forkhead box P3 in PPs were detected by the reverse transcription-polymerase chain reaction and the secretions of interferon-c(IFN-c),interleukin-4(IL-4),interleukin-17(IL-17)and transforming growth factor-b(TGF-b)in PPs were evaluated by immunohistochemistry,to reflect the differentiation of T lymphocyte in PPs to helper T(Th)cell 1,Th2,Th17 and regulatory T(Treg)cell.To confirm the correlation between SAA in Coptidis Rhizoma decoction,PPs-associated immunity and intestinal epithelium permeability,SAA were administrated on an Ussing Chamber jejunum model with immunosuppressed PPs and evaluated its influences on intestinal tissue permeability and TJ proteins expression.Results:SAA in Coptidis Rhizoma decoction could dose-dependently promote Ber absorption in jejunum segment,with the participation of PPs.The dose-dependent and dynamical regulations of SAA on permeability of intestinal tissue and TJ proteins expression level between intestinal epithelium cells occurred along with the dynamically changed T lymphocyte differentiation and immune effectors secretion in PPs.The administration of SAA on immunosuppressed PPs exhibited dose-dependent PPs activation,inducing dynamic promotion on intestinal tissue permeability and inhibition on TJ proteins expression.Conclusion:SAA can improve the Ber absorption in small intestine,through the PPs-associated immunity induced dynamic regulation on intestinal tissue permeability and TJ proteins expression.These findings might enlighten the research of traditional Chinese medicine decoction.