Integrated printed BDNF-stimulated HUCMSCs-derived exosomes/collagen/chitosan biological scaffolds with 3D printing technology promoted the remodelling of neural networks after traumatic brain injury

The restoration of nerve dysfunction after traumatic brain injury(TBI)faces huge challenges due to the limited self-regenerative abilities of nerve tissues.In situ inductive recovery can be achieved utilizing biological scaffolds combined with endogenous human umbilical cord mesenchymal stem cells(HUCMSCs)-derived exosomes(MExos).In this study,brain-derived neurotrophic factor-stimulated HUCMSCs-derived exosomes(BMExos)were composited with collagen/chitosan by 3D printing technology.3D-printed collagen/chitosan/BMExos(3D-CC-BMExos)scaffolds have excellent mechanical properties and biocompatibility.Subsequently,in vivo experiments showed that 3D-CC-BMExos therapy could improve the recovery of neuromotor function and cognitive function in a TBI model in rats.Consistent with the behavioural recovery,the results of histomorphological tests showed that 3D-CC-BMExos therapy could facilitate the remodelling of neural networks,such as improving the regeneration of nerve fibres,synaptic connections and myelin sheaths,in lesions after TBI.

Spontaneous rupture of hepatocellular carcinoma trans-arterial embolization or hepatectomy?

Spontaneous rupture and hemorrhage of hepatocellular carcinoma(HCC)is one of the serious complications leading to death in patients with primary liver cancer.Approximately 9-10%of those patients with liver cancer die of from spontaneous rupture and hemorrhage,which is often accompanied by abdominal metastasis and seriously affects their prognosis(1).

Laparoscopic cholecystectomy for double gallbladder

Double gallbladder is an embryological abnormality of relative rarity (1:4,000 human autopsies). Double gallbladder is often discovered accidentally or by complications of gallstones and cholecystitis. Herein, we present an unusual case of double gallbladder in which the cystic duct arises from the common bile duct separately and successfully treated cholecystitis with laparoscopic cholecystectomy.

More details are needed about the use of multicenter propensity score matching analysis

We read with interest a multicenter propensity score matching(PSM)analysis for patients with a solitary huge hepatocellular carcinoma(HCC),recently published in the HepatoBiliary Surgery and Nutrition(1).Surgical excision remains the primary treatment for solitary HCC,and researchers retrospectively compared the long-term prognosis of patients with balloon-shaped HCCs(BS-HCCs)and non-balloon-shaped HCCs(NBS-HCCs)after liver resection.

The efficiency of postoperative liver failure and mortality risk scores after liver resection for perihilar cholangiocarcinoma

With great interest,we read the literature by Noji et al.entitled“Validation study of postoperative liver failure and mortality risk scores after liver resection for perihilar cholangiocarcinoma”(1),which was published in the latest issue of Hepatobiliary Surgery Nutrition.The authors have reached an important conclusion that postoperative mortality risk score(POMRS)and post-hepatectomy liver failure score(PHLFS)proposed by the Academic Medical Center(AMC)and Memorial Sloan Kettering Cancer Center(MSKCC)require optimization before use in clinical practice.However,after a careful reading of this study,we would like to address several fundamental flaws related to this article.

Is liver transplantation superior to liver resection for hepatocellular carcinoma within Milan criteria?

We read with great interest the recent meta-analysis written by Koh and colleagues entitled“Liver resection versus liver transplantation for hepatocellular carcinoma within Milan criteria:a meta-analysis of 18,421 patients”(1),which was published in the latest issue of Hepatobiliary Surgery Nutrition.