Mechanical force often has clear effects on tissue niche remodeling.However,the changes in stem cells and their roles in clinical treatment remain unclear.Orthodontic tooth movement(OTM),the primary approach to treati...Mechanical force often has clear effects on tissue niche remodeling.However,the changes in stem cells and their roles in clinical treatment remain unclear.Orthodontic tooth movement(OTM),the primary approach to treating dental-maxillofacial malformations,involves reconstruction of periodontal tissue.Herein,lineage tracing revealed that Col1t cells are distributed in the periodontal ligament and are sensitive to mechanical forces during OTM.Immunofluorescence analysis confirms that Col1^(+) cells can differentiate into osteoblasts and fibroblasts under orthodontic force.Moreover,Col1^(+) cells may be involved in angiogenesis.These findings suggest that Col1t cells play a crucial role in the mechanical remodeling of periodontal tissue during OTM and may serve as a valuable tool for studying the mechanism of OTM.展开更多
基金supported in part by grants from the National Natural Science Foundation of China(82071083,82271006,82101048)the National Science Foundation of Shanghai(21ZR1436900,22ZR1436700)+8 种基金the Program of Shanghai Academic/Technology Research Leader(20XD1422300)the Cross-Disciplinary Research Fund of Shanghai Ninth People's Hospital,Shanghai Jiao Tong University School of Medicine(JYJC202116,JYJC201902)the Clinical Research Plan of SHDC(SHDC2020CR4084)the Biomaterials and Regenerative Medicine Institute Cooperative Research Project Shanghai Jiao Tong University School of Medicine(2022LHB02)the Project of Biobank of Shanghai Ninth People's Hospital,Shanghai Jiao Tong University School of Medicine(YBKB201909,YBKB202216)the Research Discipline Fund no.KQYJXK2020 from Ninth People's Hospital,Shanghai Jiao Tong University School of Medicine,and College of Stomatology,Shanghai Jiao Tong Universitythe Original Exploration Project of Shanghai Ninth People's Hospital,Shanghai Jiao Tong University School of Medicine(JYYC003)the Two-Hundred Talent Project of Shanghai Jiao Tong University School(20221809)Shanghai Science and Technology Innovation Action Plan-International Science and Technology Cooperation Program(23410713600).
文摘Mechanical force often has clear effects on tissue niche remodeling.However,the changes in stem cells and their roles in clinical treatment remain unclear.Orthodontic tooth movement(OTM),the primary approach to treating dental-maxillofacial malformations,involves reconstruction of periodontal tissue.Herein,lineage tracing revealed that Col1t cells are distributed in the periodontal ligament and are sensitive to mechanical forces during OTM.Immunofluorescence analysis confirms that Col1^(+) cells can differentiate into osteoblasts and fibroblasts under orthodontic force.Moreover,Col1^(+) cells may be involved in angiogenesis.These findings suggest that Col1t cells play a crucial role in the mechanical remodeling of periodontal tissue during OTM and may serve as a valuable tool for studying the mechanism of OTM.
