A pelvic endoprosthesis is the primary means of pelvic reconstruction after internal hemipelvectomy. In this study, a novel biomimetic hemipelvic prosthesis, including an artificial ilium, an artificial acetabulum, an...A pelvic endoprosthesis is the primary means of pelvic reconstruction after internal hemipelvectomy. In this study, a novel biomimetic hemipelvic prosthesis, including an artificial ilium, an artificial acetabulum, and an artificial pubis, was developed. A Finite Element Method （FEM） was carried out to investigate the biomechanical performance of a pelvis reconstructed with biomimetic hemipelvic prosthesis. Two models, including the reconstructed pelvis and the original pelvis （control model）, were established according to the geometry from CT data of a human male patient with pelvic bone sarcomas. The FE models predict that the biomeehanical function of the pelvic ring can be reestablished using this prosthesis. Results show that the body force loaded on the S 1 vertebra is restored and transferred towards the sacro-iliac joint, and along the ilium onto the bearing surface of the artificial ilium, then to the artificial acetabulum and pubis. Von Mises stresses observed in this reconstructed pelvis model are still within a low and elastic range below the yielding strength of cortical bone and Ti6A14V. The values of deformation and strain of the reconstructed pelvis are close to the data obtained in the original pelvis. With the partial replacement of the pubis, little influence is found towards the pubis symphysis. However, the interface between the prosthesis and pelvic bone may become the critical part of the reconstructed pelvis due to the discontinuity in the material properties, which results in stress shielding and deformation constraining. So a biomimetic flexible connection or inter layer to release the deformation of pelvis is suggested in future designing.展开更多
We consider the special case that the dark matter(DM) candidate is not detected in direct-detection programs when the experimental sensitivity reaches the neutrino flux background. In such circumstance the DM searches...We consider the special case that the dark matter(DM) candidate is not detected in direct-detection programs when the experimental sensitivity reaches the neutrino flux background. In such circumstance the DM searches at the colliders impose constraints on the DM relic abundance if the DM candidate is a WIMPs type. Specifically, we consider the triplet(quintet and septet) DMs in the framework of minimal DM model and explore the potential of discovering the DM candidate in the mono-jet, mono-photon and vector boson fusion channels at the Large Hadron Collider(LHC) and future 100 TeV hadron collider. If the DM candidate in such a scenario is discovered at the LHC, then additional DM candidates are needed to explain the observed relic abundance.On the other hand, null results in those DM searching programs at the colliders give rise to lower limits of DM relic abundance.展开更多
基金This research was supported by National Natural Science Foundation of China （No. 51205241）, the Re- search Fund for the Doctoral Program of Higher Educa- tion of China （20123108120008）, the Shanghai Mu- nicipal Education Commission, Shanghai Young Scien- tists Program （37010911004）, and the Innovation Fund of Shanghai University.
文摘A pelvic endoprosthesis is the primary means of pelvic reconstruction after internal hemipelvectomy. In this study, a novel biomimetic hemipelvic prosthesis, including an artificial ilium, an artificial acetabulum, and an artificial pubis, was developed. A Finite Element Method （FEM） was carried out to investigate the biomechanical performance of a pelvis reconstructed with biomimetic hemipelvic prosthesis. Two models, including the reconstructed pelvis and the original pelvis （control model）, were established according to the geometry from CT data of a human male patient with pelvic bone sarcomas. The FE models predict that the biomeehanical function of the pelvic ring can be reestablished using this prosthesis. Results show that the body force loaded on the S 1 vertebra is restored and transferred towards the sacro-iliac joint, and along the ilium onto the bearing surface of the artificial ilium, then to the artificial acetabulum and pubis. Von Mises stresses observed in this reconstructed pelvis model are still within a low and elastic range below the yielding strength of cortical bone and Ti6A14V. The values of deformation and strain of the reconstructed pelvis are close to the data obtained in the original pelvis. With the partial replacement of the pubis, little influence is found towards the pubis symphysis. However, the interface between the prosthesis and pelvic bone may become the critical part of the reconstructed pelvis due to the discontinuity in the material properties, which results in stress shielding and deformation constraining. So a biomimetic flexible connection or inter layer to release the deformation of pelvis is suggested in future designing.
基金supported by the National Natural Science Foundation of China(Grant Nos.11275009,11675002,11635001,and 11725520)supported by the National Research Foundation of Korea(Grant No.2017R1D1A1B03030820)
文摘We consider the special case that the dark matter(DM) candidate is not detected in direct-detection programs when the experimental sensitivity reaches the neutrino flux background. In such circumstance the DM searches at the colliders impose constraints on the DM relic abundance if the DM candidate is a WIMPs type. Specifically, we consider the triplet(quintet and septet) DMs in the framework of minimal DM model and explore the potential of discovering the DM candidate in the mono-jet, mono-photon and vector boson fusion channels at the Large Hadron Collider(LHC) and future 100 TeV hadron collider. If the DM candidate in such a scenario is discovered at the LHC, then additional DM candidates are needed to explain the observed relic abundance.On the other hand, null results in those DM searching programs at the colliders give rise to lower limits of DM relic abundance.
