BACKGROUND: Quantitative pharmaco-electroencephalography can be used for studying the dose-effect and time-effect relationships of drugs affecting central nervous system. Therefore, it may become an effective means f...BACKGROUND: Quantitative pharmaco-electroencephalography can be used for studying the dose-effect and time-effect relationships of drugs affecting central nervous system. Therefore, it may become an effective means for monitoring the anesthetic degree of anesthetic drug in the operation. OBJECTIVE: To observe the dose-effect relationship of propofol influencing β2-band power of quantitative pharmaco-electroencephalography in rabbits. DESIGN: A randomized block design. SETTING: Department of Anesthesiology, Xuzhou Medical College. MATERIALS: Thirty-six healthy adult rabbits of either gender, weighing (2.4 ± 0.5 ) kg, of clean grade, were provided by the Laboratory Animal Center of Xuzhou Medical College. The involved rabbits were randomly divided into 3 groups with 12 in each by table of random digit: high-dose propofol group, moderate-dose propofol group, and low-dose propofol group. The protocol was carried out in accordance with animal ethics guidelines for the use and care of animals. METHODS: This study was carried out in the Department of Anesthesiology, Xuzhou Medical College between August 1999 and April 2000. Rabbits in the high-dose propofol group, moderate-dose propofol group, and low-dose propofol group were injected with 10, 5 and 2.5 mg/kg propofol (ZENECA Company, British, Batch No. 032000), respectively. Before and after intravenous administration of propofol, percentage of β2-band power of quantitative pharmaco-electroencephalography was measured, and the latent and persistent periods when rabbit righting reflex disappeared were observed by quantitative pharmaco-electroencephalography and power spectrum analysis. MAIN OUTCOME MEASURES: (1) Percentage of β2-band power of quantitative pharmaco-electroencephalography. (2)Latent period and persistent period of abolition of righting reflex of rabbits. RESULTS: Thirty-six rabbits were involved in the final analysis. (1)Effect of propofol on righting reflex of rabbits: Righting reflex disappeared within 1 minute after the rabbits being intravenously injected with propofol. The higher dose, the shorter latent period (r = - 0.94, P 〈 0.01), and the longer persistent period (r =0.79, P 〈 0.01). Both latent period and persistent period had good correlation with propofol dose. (2) Effect of propofol on the percentage of β2-band power of quantitative pharmaco-electroencephalography: In the low-dose propofol group, no significant changes in the percentage of β2-band power of quantitative pharmaco-electroencephalography existed between before and after administration within 30 minutes (P 〉 0.05). In the moderate-dose propofol group, the percentage of β2-band power of quantitative pharmaco-electroencephalography in each brain region except for left and right frontal areas was significantly decreased within 30 s to 5 minutes (P 〈 0.05), and recovered to the level before administration 10 minutes later. In the high-dose propofol group, the percentage of β2-band power of quantitative pharmaco-electroencephalography in each brain region was significantly decreased from 20 s to 5 minutes after administration (P 〈 0.05 - 0.01), and that was gradually recovered to the level before administration 5 to 10 minutes after administration. This tendency was basically the same as the changes of latent period and persistent period. CONCLUSION: Propofol decreases the percentage of β2-band power of quantitative pharmacoelectroencephalography in dose-dependent manner, It indicates that β2-band power might become one of indexes for reflecting the anesthetic degree of propofol,展开更多
Radiotherapy is one of important approaches for pulmonary adenocarcinoma. However, many studies have shown that radiation can also enhance the ability of tumor cells metastasis, although the lung adenocarcinoma could ...Radiotherapy is one of important approaches for pulmonary adenocarcinoma. However, many studies have shown that radiation can also enhance the ability of tumor cells metastasis, although the lung adenocarcinoma could be killed. The increased metastasis induced by radiation is associated with the activation of STAT3?in lung adenocarcinoma cells. Based on the importance role of?STAT3?in cell proliferation and survival, we can construct an adenovirus vector of?PIAS3 overexpress driven by radiation-induced promoter to inhibit the activation of STAT3 specifically. In this way, when?STAT3 was activated by radiation, the expression of?PIAS3 will be increased at the same time;this lead to the inhibition of invasion and metastasis caused by?STAT3 in lung adenocarcinoma cells. These researches are expected to develop a novel target and method for radiotherapy and molecular therapy of lung adenocarcinoma.展开更多
Considering the acoustic source scattering problems,when the sour-ce is non-radiating/invisible,we investigate the geometrical characterization for the underlying sources at polyhedral and conical corner.It is reveale...Considering the acoustic source scattering problems,when the sour-ce is non-radiating/invisible,we investigate the geometrical characterization for the underlying sources at polyhedral and conical corner.It is revealed that the non-radiating source with Holder continuous regularity must vanish at the corner.Using this kind of geometrical characterization of non-radiating sources,we establish local and global unique determination for a source with the polyhedral or corona shape support by a single far field measurement.Uniqueness by a single far field measurement constitutes of a long standing problem in inverse scattering problems.展开更多
A form stable NaCl-Al2O3(50-50 wt-%)composite material for high temperature thermal energy storage was fabricated by cold sintering process,a process recently applied to the densification of ceramics at low temperatur...A form stable NaCl-Al2O3(50-50 wt-%)composite material for high temperature thermal energy storage was fabricated by cold sintering process,a process recently applied to the densification of ceramics at low temperature 300℃ under uniaxial pressure in the presence of small amount o f transient liquid.The fabricated composite achieved as high as 98.65% of the theoretical density.The NaCl-Al2O3 composite also retained the chloride salt without leakage after 30 heating-cooling cycles between 750℃-850℃ together with a holding period o f 24h at 850℃.X-ray diffraction measurements indicated congruent solubility o f the alumina in chloride salt,excellent compatibility o f NaCl with Al2O3,and chemical stability at high temperature.Structural analysis by scanning electron microscope also showed limited grain growth,high density,uniform NaCl distribution and clear faceted composite structure without inter-diffusion.The latent heat storage density o f 252.5J/g was obtained from simultaneous thermal analysis.Fracture strength test showed high sintered strength around 5 GPa after 50 min.The composite was found to have fair mass losses due to volatilization.Overall,cold sintering process has the potential to be an efficient,safe and cost-effective strategy for the fabrication of high temperature thermal energy storage materials.展开更多
基金the National Natural Science Foundation of China, No. 30471657,39970715Social Development Plan Project of Science Committee of Jiangsu Province, No.BS2000052the Natural Science Foundation of Jiangsu Province, No.BK2001143
文摘BACKGROUND: Quantitative pharmaco-electroencephalography can be used for studying the dose-effect and time-effect relationships of drugs affecting central nervous system. Therefore, it may become an effective means for monitoring the anesthetic degree of anesthetic drug in the operation. OBJECTIVE: To observe the dose-effect relationship of propofol influencing β2-band power of quantitative pharmaco-electroencephalography in rabbits. DESIGN: A randomized block design. SETTING: Department of Anesthesiology, Xuzhou Medical College. MATERIALS: Thirty-six healthy adult rabbits of either gender, weighing (2.4 ± 0.5 ) kg, of clean grade, were provided by the Laboratory Animal Center of Xuzhou Medical College. The involved rabbits were randomly divided into 3 groups with 12 in each by table of random digit: high-dose propofol group, moderate-dose propofol group, and low-dose propofol group. The protocol was carried out in accordance with animal ethics guidelines for the use and care of animals. METHODS: This study was carried out in the Department of Anesthesiology, Xuzhou Medical College between August 1999 and April 2000. Rabbits in the high-dose propofol group, moderate-dose propofol group, and low-dose propofol group were injected with 10, 5 and 2.5 mg/kg propofol (ZENECA Company, British, Batch No. 032000), respectively. Before and after intravenous administration of propofol, percentage of β2-band power of quantitative pharmaco-electroencephalography was measured, and the latent and persistent periods when rabbit righting reflex disappeared were observed by quantitative pharmaco-electroencephalography and power spectrum analysis. MAIN OUTCOME MEASURES: (1) Percentage of β2-band power of quantitative pharmaco-electroencephalography. (2)Latent period and persistent period of abolition of righting reflex of rabbits. RESULTS: Thirty-six rabbits were involved in the final analysis. (1)Effect of propofol on righting reflex of rabbits: Righting reflex disappeared within 1 minute after the rabbits being intravenously injected with propofol. The higher dose, the shorter latent period (r = - 0.94, P 〈 0.01), and the longer persistent period (r =0.79, P 〈 0.01). Both latent period and persistent period had good correlation with propofol dose. (2) Effect of propofol on the percentage of β2-band power of quantitative pharmaco-electroencephalography: In the low-dose propofol group, no significant changes in the percentage of β2-band power of quantitative pharmaco-electroencephalography existed between before and after administration within 30 minutes (P 〉 0.05). In the moderate-dose propofol group, the percentage of β2-band power of quantitative pharmaco-electroencephalography in each brain region except for left and right frontal areas was significantly decreased within 30 s to 5 minutes (P 〈 0.05), and recovered to the level before administration 10 minutes later. In the high-dose propofol group, the percentage of β2-band power of quantitative pharmaco-electroencephalography in each brain region was significantly decreased from 20 s to 5 minutes after administration (P 〈 0.05 - 0.01), and that was gradually recovered to the level before administration 5 to 10 minutes after administration. This tendency was basically the same as the changes of latent period and persistent period. CONCLUSION: Propofol decreases the percentage of β2-band power of quantitative pharmacoelectroencephalography in dose-dependent manner, It indicates that β2-band power might become one of indexes for reflecting the anesthetic degree of propofol,
文摘Radiotherapy is one of important approaches for pulmonary adenocarcinoma. However, many studies have shown that radiation can also enhance the ability of tumor cells metastasis, although the lung adenocarcinoma could be killed. The increased metastasis induced by radiation is associated with the activation of STAT3?in lung adenocarcinoma cells. Based on the importance role of?STAT3?in cell proliferation and survival, we can construct an adenovirus vector of?PIAS3 overexpress driven by radiation-induced promoter to inhibit the activation of STAT3 specifically. In this way, when?STAT3 was activated by radiation, the expression of?PIAS3 will be increased at the same time;this lead to the inhibition of invasion and metastasis caused by?STAT3 in lung adenocarcinoma cells. These researches are expected to develop a novel target and method for radiotherapy and molecular therapy of lung adenocarcinoma.
基金the National Natural Science Foundation of China(Grant No.12371422)the Fundamental Research Funds for the Central Universities,JLU(Grant No.93Z172023Z01)+3 种基金The work of Y.Geng is supported by the Graduate Innovation Fund of Jilin University(Grant No.2023Cx276)the Hong Kong RGC General Research Funds(Projects 12302919,12301420 and 11300821)the NSFC/RGC Joint Research Fund(Project N.City U101/21)the France-Hong Kong ANR/RGCJoint Research(Grant No.A-HKBU 203/19).
文摘Considering the acoustic source scattering problems,when the sour-ce is non-radiating/invisible,we investigate the geometrical characterization for the underlying sources at polyhedral and conical corner.It is revealed that the non-radiating source with Holder continuous regularity must vanish at the corner.Using this kind of geometrical characterization of non-radiating sources,we establish local and global unique determination for a source with the polyhedral or corona shape support by a single far field measurement.Uniqueness by a single far field measurement constitutes of a long standing problem in inverse scattering problems.
文摘A form stable NaCl-Al2O3(50-50 wt-%)composite material for high temperature thermal energy storage was fabricated by cold sintering process,a process recently applied to the densification of ceramics at low temperature 300℃ under uniaxial pressure in the presence of small amount o f transient liquid.The fabricated composite achieved as high as 98.65% of the theoretical density.The NaCl-Al2O3 composite also retained the chloride salt without leakage after 30 heating-cooling cycles between 750℃-850℃ together with a holding period o f 24h at 850℃.X-ray diffraction measurements indicated congruent solubility o f the alumina in chloride salt,excellent compatibility o f NaCl with Al2O3,and chemical stability at high temperature.Structural analysis by scanning electron microscope also showed limited grain growth,high density,uniform NaCl distribution and clear faceted composite structure without inter-diffusion.The latent heat storage density o f 252.5J/g was obtained from simultaneous thermal analysis.Fracture strength test showed high sintered strength around 5 GPa after 50 min.The composite was found to have fair mass losses due to volatilization.Overall,cold sintering process has the potential to be an efficient,safe and cost-effective strategy for the fabrication of high temperature thermal energy storage materials.