Macro-and micro-interface instability of SiO_(x)anode caused by its dramatic volume variation during cycling will result in low Coulombic efficiency and rapid capacity degradation.In this work,an organic-inorganic com...Macro-and micro-interface instability of SiO_(x)anode caused by its dramatic volume variation during cycling will result in low Coulombic efficiency and rapid capacity degradation.In this work,an organic-inorganic composite interfacial layer rich in benzene ring groups,polyisocyanates,and LiF was obtained on SiO_(x)anode by the introduction of 4-fluorophenyl isocyanate(FPI)and fluoroethylene carbonate(FEC)co-additives in electrolyte.The SiO_(x)anode material shows a capacity retention of 69.2%after 100 cycles at a current density of 1 A g^(-1)and rate capacity of 523 m A h g^(-1)at the current density of 3A g^(-1),while the SiO_(x)anode cycling in reference electrolyte has almost no capacity.展开更多
Myxozoans are common microscopic endoparasites in fish,and some are highly pathogenic to their wild and farmed fish hosts.In the present study,myxosporeans infection in the kidney of silver carp Hypophthalmichthys mol...Myxozoans are common microscopic endoparasites in fish,and some are highly pathogenic to their wild and farmed fish hosts.In the present study,myxosporeans infection in the kidney of silver carp Hypophthalmichthys molitrix(Valenciennes,1844)from Lake Taihu,was investigated,and two dominate species,Myxobolus lieni(Nie&Li,1973)and M.varius(Achmerov,1960),with infection prevalence 60.2%and 35.2%,respectively,were well characterized based on morphological,histopathological and DNA sequence data.M.lieni formed small roundish plasmodia in the epithelial cells of renal tubules.The mature myxospores appeared suborbicular,slightly flat in frontal view and fusiform shaped in sutural view.Dispersed myxospores of M.varius were found in the renal interstitium without forming plasmodia structures and enclosed within melano-macrophage centers.The spore appeared elliptical in frontal view,with wider anterior than posterior and shuttle shaped in sutural view.Interestingly,the occurrence of myxozoans in the kidney detected with SSU rDNA PCR and clone sequencing,revealed co-infection of five Myxobolus species.BLASTn search indicated SSU r DNA gene sequences obtained here were not identical to any sequence available in GenBank.Phylogenetic analyses showed that the five Myxobolus species detected here were clustered together,forming a separate clade of cyprinid-infecting myxozoans.展开更多
An effective eradication therapy of Helicobacter pylori(H.pylori)should be used for the first time.In this study,we assessed whether tailored therapy based on antibiotic susceptibility testing is more effective than t...An effective eradication therapy of Helicobacter pylori(H.pylori)should be used for the first time.In this study,we assessed whether tailored therapy based on antibiotic susceptibility testing is more effective than traditional therapy.We also evaluated the factors that cause treatment failure in high-resistance areas.For this multicenter trial,we recruited 467 H.pylori-positive patients.The patients were randomly assigned to receive tailored triple therapy(TATT),tailored bismuth-containing quadruple therapy(TABQT),or traditional bismuthcontaining quadruple therapy(TRBQT).For the TATT and TABQT groups,antibiotic selection proceeded via susceptibility testing using an agar-dilution test.The patients in the TRBQT group were given amoxicillin,clarithromycin,esomeprazole,and bismuth.Successful eradication was defined as a negative 13C-urea breath test at least eight weeks after the treatment ended.Susceptibility testing was conducted using an agar-dilution test.The eradication rate was examined via intention-to-treat(ITT)and per-protocol(PP)analyses.The clarithromycin,levofloxacin,and metronidazole resistance rates were 26.12%,28.69%,and 96.79%,respectively.Resistance against amoxicillin and furazolidone was rare.The eradication rates for TATT,TRBQT,and TABQT were 67.32%,63.69%,and 85.99%in the ITT analysis(P<0.001)and 74.64%,68.49%,and 91.22%in the PP analysis(P<0.001),respectively.The efficacy of TABQTwas affected by clarithromycin resistance,and bismuth exerted a direct influence on TATT failure.TABQT was the most efficacious regimen for use in high-resistance regions,especially among clarithromycin-susceptible patients.展开更多
基金financially supporting from the Key-Area Research and Development Program of Guangdong Province(2020B090919005)the Fundamental Research Funds for the Central Universities(HIT.OCEF.2021008)+2 种基金the Key Research and Development Program of Heilongjiang Province(GA21A102)the Natural Science Foundation of Chongqing(cstc2021jcyj-msxmX0958)the National Natural Science Foundation of China(51772068)。
文摘Macro-and micro-interface instability of SiO_(x)anode caused by its dramatic volume variation during cycling will result in low Coulombic efficiency and rapid capacity degradation.In this work,an organic-inorganic composite interfacial layer rich in benzene ring groups,polyisocyanates,and LiF was obtained on SiO_(x)anode by the introduction of 4-fluorophenyl isocyanate(FPI)and fluoroethylene carbonate(FEC)co-additives in electrolyte.The SiO_(x)anode material shows a capacity retention of 69.2%after 100 cycles at a current density of 1 A g^(-1)and rate capacity of 523 m A h g^(-1)at the current density of 3A g^(-1),while the SiO_(x)anode cycling in reference electrolyte has almost no capacity.
基金supported the earmarked fund for China Agriculture Research System of MOF and MARA(CARS-45)Natural Sciences Foundation of China(32073019)。
文摘Myxozoans are common microscopic endoparasites in fish,and some are highly pathogenic to their wild and farmed fish hosts.In the present study,myxosporeans infection in the kidney of silver carp Hypophthalmichthys molitrix(Valenciennes,1844)from Lake Taihu,was investigated,and two dominate species,Myxobolus lieni(Nie&Li,1973)and M.varius(Achmerov,1960),with infection prevalence 60.2%and 35.2%,respectively,were well characterized based on morphological,histopathological and DNA sequence data.M.lieni formed small roundish plasmodia in the epithelial cells of renal tubules.The mature myxospores appeared suborbicular,slightly flat in frontal view and fusiform shaped in sutural view.Dispersed myxospores of M.varius were found in the renal interstitium without forming plasmodia structures and enclosed within melano-macrophage centers.The spore appeared elliptical in frontal view,with wider anterior than posterior and shuttle shaped in sutural view.Interestingly,the occurrence of myxozoans in the kidney detected with SSU rDNA PCR and clone sequencing,revealed co-infection of five Myxobolus species.BLASTn search indicated SSU r DNA gene sequences obtained here were not identical to any sequence available in GenBank.Phylogenetic analyses showed that the five Myxobolus species detected here were clustered together,forming a separate clade of cyprinid-infecting myxozoans.
基金supported by the Science and Technology Program of Wenzhou(No.2014S0193)Public Technology Application Research of Zhejiang Province Science and Technology Hall(No.2014C33246)+1 种基金Medical and Health Plan of Zhejiang Province(No.2015DTA020)Public Technology Application Research of Zhejiang Province Science and Technology Hall(No.2016C33232).
文摘An effective eradication therapy of Helicobacter pylori(H.pylori)should be used for the first time.In this study,we assessed whether tailored therapy based on antibiotic susceptibility testing is more effective than traditional therapy.We also evaluated the factors that cause treatment failure in high-resistance areas.For this multicenter trial,we recruited 467 H.pylori-positive patients.The patients were randomly assigned to receive tailored triple therapy(TATT),tailored bismuth-containing quadruple therapy(TABQT),or traditional bismuthcontaining quadruple therapy(TRBQT).For the TATT and TABQT groups,antibiotic selection proceeded via susceptibility testing using an agar-dilution test.The patients in the TRBQT group were given amoxicillin,clarithromycin,esomeprazole,and bismuth.Successful eradication was defined as a negative 13C-urea breath test at least eight weeks after the treatment ended.Susceptibility testing was conducted using an agar-dilution test.The eradication rate was examined via intention-to-treat(ITT)and per-protocol(PP)analyses.The clarithromycin,levofloxacin,and metronidazole resistance rates were 26.12%,28.69%,and 96.79%,respectively.Resistance against amoxicillin and furazolidone was rare.The eradication rates for TATT,TRBQT,and TABQT were 67.32%,63.69%,and 85.99%in the ITT analysis(P<0.001)and 74.64%,68.49%,and 91.22%in the PP analysis(P<0.001),respectively.The efficacy of TABQTwas affected by clarithromycin resistance,and bismuth exerted a direct influence on TATT failure.TABQT was the most efficacious regimen for use in high-resistance regions,especially among clarithromycin-susceptible patients.
