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超声检查对肠系膜上动脉综合征的诊断价值
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作者 蒋清凌 覃斯 +2 位作者 胡美玉 谢佩怡 刘广健 《中华医学超声杂志(电子版)》 CSCD 北大核心 2023年第11期1174-1180,共7页
目的筛选常规超声、口服胃窗造影剂超声及两者联合对肠系膜上动脉综合征(SMAS)的诊断标准并比较其诊断价值。方法连续性纳入2020年2月至2022年2月因不明原因腹痛、腹胀、恶心、呕吐、反胃、体质量下降等原因来中山大学附属第六医院就诊... 目的筛选常规超声、口服胃窗造影剂超声及两者联合对肠系膜上动脉综合征(SMAS)的诊断标准并比较其诊断价值。方法连续性纳入2020年2月至2022年2月因不明原因腹痛、腹胀、恶心、呕吐、反胃、体质量下降等原因来中山大学附属第六医院就诊,临床疑诊SMAS行超声检查的患者51例。常规超声记录腹主动脉与肠系膜上动脉之间夹角(AMA)、腹主动脉与肠系膜上动脉之间距离(AMD)。口服胃窗造影剂超声记录腹主动脉与肠系膜上动脉夹角内十二指肠内径(D1)、夹角前十二指肠内径(D2)及D2/D1。回顾性分析所有超声检查资料,以对比增强计算机断层扫描(CECT)及上消化道钡餐作为诊断金标准,应用受试者工作特征(ROC)曲线分析并获得常规超声及口服胃窗造影剂超声的诊断指标,比较常规超声、口服胃窗造影剂超声及两者联合诊断SMAS的诊断价值。结果根据ROC曲线筛查出常规超声诊断SMAS的指标为:AMA≤16°[曲线下面积(AUC)=0.806]、AMD≤3.3 mm(AUC=0.685);口服胃窗造影剂超声诊断SMAS的指标为:D1≤5.5 mm(AUC=0.849)、D2≥19 mm(AUC=0.725)、D2/D1≥2.9(AUC=0.884)。常规超声、口服胃窗造影剂超声及两者联合分别以AMA≤16°或AMD≤3.3 mm、D2/D1≥2.9及AMA≤16°或AMD≤3.3 mm且D2/D1≥2.9为诊断标准,三者诊断SMAS的敏感度分别为95.2%、85.7%和85.7%,特异度分别为53.3%、83.3%和93.3%,准确性分别为70.6%、84.3%和90.2%,AUC分别为0.743、0.845和0.895。结论常规超声联合口服胃窗造影剂超声可作为临床诊断SMAS的有效方案。 展开更多
关键词 肠系膜上动脉综合征 常规超声 口服胃窗造影剂超声 诊断
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Low copy numbers for mitochondrial DNA moderates the strength of nuclear-cytoplasmic incompatibility in plants
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作者 Liguang Zhang Jin Ma +8 位作者 Zhaorui Shen Bo Wang qingling jiang Fei Ma Yan Ju Guangxing Duan Quan Zhang Xiaodong Su Sodmergen 《Journal of Integrative Plant Biology》 SCIE CAS CSCD 2023年第3期739-754,共16页
Plant cells contain only small amounts of mitochondrial DNA(mtDNA), with the genomic information shared among multiple mitochondria.The biological relevance and molecular mechanism underlying this hallmark of plant ce... Plant cells contain only small amounts of mitochondrial DNA(mtDNA), with the genomic information shared among multiple mitochondria.The biological relevance and molecular mechanism underlying this hallmark of plant cells has been unclear. Here, we report that Arabidopsis thaliana plants exhibited significantly reduced growth and mitochondrial dysfunction when the mtDNA copy number was increased to the degree that each mitochondrion possessed DNA.The amounts of mitochondrion-encoded transcripts increased several fold in the presence of elevated mtDNA levels. However, the efficiency of RNA editing decreased with this excess of mitochondrion-encoded transcripts, resulting in impaired assembly of mitochondrial complexes containing mtDNA-encoded subunits, such as respiratory complexes I and IV. These observations indicate the occurrence of nuclear–mitochondrial incompatibility in the cells with increased amounts of mtDNA and provide an initial answer to the fundamental question of why plant cells have much lower mtDNA levels than animal cells. We propose that keeping mtDNA levels low moderates nuclear–mitochondrial incompatibility and that this may be a crucial factor driving plant cells to restrict the copy numbers of mtDNA. 展开更多
关键词 ARABIDOPSIS low-copy mtDNA plant MITOCHONDRIA mitochondrial DNA
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