Pyridinium 1,4-zwitterionic thiolates were applied to a formal [3+2] annulation reaction with modified activated alkynes, affording various tetrasubstituted thiophenes with aryl, alkenyl, alkyl or silyl group at the s...Pyridinium 1,4-zwitterionic thiolates were applied to a formal [3+2] annulation reaction with modified activated alkynes, affording various tetrasubstituted thiophenes with aryl, alkenyl, alkyl or silyl group at the special position. The structural modification of alkyne substrates enabled the synthesis of diverse thiophenes to be achieved using the pyridinium 1,4-zwitterionic thiolates as the sulfur-containing building blocks. This approach is metal-free and catalyst-free.展开更多
基金supported by the National Key Plan for Scientific Research and Development of China(2020YFA0509304 and 2021YFA0805300)the Chinese Academy of Sciences(XDB39000000)+3 种基金the National Natural Science Foundation of China(82030034,32121002,and 81971123)CAMS Innovation Fund for Medical Sciences(2021-I2M-C&T-B-012)the Fundamental Research Funds for the Central Universities(YD9110002027)the Guangzhou Key Research Program on Brain Science(202007030008)。
基金National Natural Science Foundation of China (Nos. 21971092, 21901014, 21472072, 21871018, 21732001 and 21672017)Shenzhen Science and Technology Innovation Committee (No. JCYJ20200109141808025)Characteristic Innovation Project of Guangdong Provincial Education Department (No. 2020KTSCX295) for the financial support。
文摘Pyridinium 1,4-zwitterionic thiolates were applied to a formal [3+2] annulation reaction with modified activated alkynes, affording various tetrasubstituted thiophenes with aryl, alkenyl, alkyl or silyl group at the special position. The structural modification of alkyne substrates enabled the synthesis of diverse thiophenes to be achieved using the pyridinium 1,4-zwitterionic thiolates as the sulfur-containing building blocks. This approach is metal-free and catalyst-free.
