An efficient catalytic system was successfully developed on reduction of A/-heteroaromatics with H3N-BH3 as hydrogen source in CuSO4 solution,featuri ng excel I e nt chemoselectivity as well as very broad functional g...An efficient catalytic system was successfully developed on reduction of A/-heteroaromatics with H3N-BH3 as hydrogen source in CuSO4 solution,featuri ng excel I e nt chemoselectivity as well as very broad functional group tolera nee.Various challe nging substrates,such as OH-,NH_(2)^(-), Cl^(-),Br^(-),etc.,contained quinolines,quinoxalines,1,5-naphthyridines and quinazolines were all reduced smoothly.Mecha nistic studies suggested that[Cu-H]in termediate might be gen erated from NH_(3)·BH_(3)/which was believed to form with H3N-BH3 in CuSO_(4) solution.展开更多
Chemoselective reductions ofα,β-unsaturated ketones to afford the corresponding allylic alcohols have always been challenging.Precious metals and ligands have always been employed in these transform-ations.
基金Financial support from the National Natural Science Founda-tion of China(Nos.21702065,21772046 and 2193103)the Promotion Program for Young and Middle-aged Teacher in Science and Tech no logy Research of Huaqiao Un iversity is gratefully ackno wledged.
文摘An efficient catalytic system was successfully developed on reduction of A/-heteroaromatics with H3N-BH3 as hydrogen source in CuSO4 solution,featuri ng excel I e nt chemoselectivity as well as very broad functional group tolera nee.Various challe nging substrates,such as OH-,NH_(2)^(-), Cl^(-),Br^(-),etc.,contained quinolines,quinoxalines,1,5-naphthyridines and quinazolines were all reduced smoothly.Mecha nistic studies suggested that[Cu-H]in termediate might be gen erated from NH_(3)·BH_(3)/which was believed to form with H3N-BH3 in CuSO_(4) solution.
基金Financial support from the National Natural Science Foundation(21702065,21772046 and 21931013)the Promotion Program for Young and Middle-aged Teacher in Science and Technology Research of Huaqiao University,the Guangdong Provincial Key Laboratory of Catalysis(No.2020B121201002)Open Research Fund of School of Chemistry and Chemical Engineering,Henan Normal University is gratefully acknowledged.
文摘Chemoselective reductions ofα,β-unsaturated ketones to afford the corresponding allylic alcohols have always been challenging.Precious metals and ligands have always been employed in these transform-ations.
