Cancer cells in the tumormicroenvironment,where nutrient availability is consistently changing during tumor progression,harness lipid metabolism to support their proliferation,survival,migration,invasion,and metastasi...Cancer cells in the tumormicroenvironment,where nutrient availability is consistently changing during tumor progression,harness lipid metabolism to support their proliferation,survival,migration,invasion,and metastasis[1].When nutrients in the tumor microenvironment are sufficient,lipids such as triglycerides,steryl esters,and retinyl esters are stored in lipid droplets,which are dynamic lipid-rich cellular organelles surrounded by a single layer of polar and amphipathic phospholipids and structural proteins in the perilipin(PLIN)family.展开更多
Of the 20 ribosomally coded amino acid residues,lysine(K)can be frequently and uniquely modified by many types of posttranslational acylation,including acetylation,succinylation,crotonylation,propionylation,butyrylati...Of the 20 ribosomally coded amino acid residues,lysine(K)can be frequently and uniquely modified by many types of posttranslational acylation,including acetylation,succinylation,crotonylation,propionylation,butyrylation,glutarylation,malonylation,β-hydroxybutyrylation,and 2-hydroxyisobutyrylation in histones and other proteins(Li et al.,2018a;Xu et al.,2021).Among these acylations,succinylation is a commonly occurred modification,and histone H3K79 succinylation is identified in the transcription start sites of more than 7,000 genes,implying its critical role in the expression regulation of a large number of genes(Wang et al.,2017).Protein succinylation requires the highenergy metabolite,succinyl-coenzyme A(CoA).展开更多
文摘Cancer cells in the tumormicroenvironment,where nutrient availability is consistently changing during tumor progression,harness lipid metabolism to support their proliferation,survival,migration,invasion,and metastasis[1].When nutrients in the tumor microenvironment are sufficient,lipids such as triglycerides,steryl esters,and retinyl esters are stored in lipid droplets,which are dynamic lipid-rich cellular organelles surrounded by a single layer of polar and amphipathic phospholipids and structural proteins in the perilipin(PLIN)family.
基金This study was supported by grants from Ministry of Science and Technology of the People's Republic of China(2020YFA0803300,Z.L.)the National Natural Science Foundation of China(82188102,82030074,Z.L.+3 种基金81902423,D.G.)the Zhejiang University Research Fund(188020*194221901/029,Z.L.)the Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang(2019R01001,Z.L.)the Scientific Research Project of Beijing Municipal Education Commission(KM202110025002,Y.T.).Z.L.is the Kuancheng Wang Distinguished Chair.
文摘Of the 20 ribosomally coded amino acid residues,lysine(K)can be frequently and uniquely modified by many types of posttranslational acylation,including acetylation,succinylation,crotonylation,propionylation,butyrylation,glutarylation,malonylation,β-hydroxybutyrylation,and 2-hydroxyisobutyrylation in histones and other proteins(Li et al.,2018a;Xu et al.,2021).Among these acylations,succinylation is a commonly occurred modification,and histone H3K79 succinylation is identified in the transcription start sites of more than 7,000 genes,implying its critical role in the expression regulation of a large number of genes(Wang et al.,2017).Protein succinylation requires the highenergy metabolite,succinyl-coenzyme A(CoA).
