Modified Blumgart anastomosis without pancreatic duct-to-jejunum mucosa anastomosis for pancreatoduodenectomy：a feasible and safe novel technique

Objective:This study proposed a modified Blumgart anastomosis(m-BA)that uses a firm ligation of the main pancreatic duct with a supporting tube to replace the pancreatic duct-to-jejunum mucosa anastomosis,with the aim of simplifying the complicated steps of the conventional BA(c-BA).Thus,we observe if a difference in the risk of postoperative pancreatic fistula(POPF)exists between the two methods.Methods:The m-BA anastomosis method has been used since 2010.From October 2011 to October 2015,147 patients who underwent pancreatoduodenectomy(PD)using BA in Tianjin Medical University Cancer Institute and Hospital were enrolled in this study.According to the type of pancreatojejunostomy(PJ),50 patients underwent m-BA and 97 received c-BA.The two patient cohorts were compared prospectively to some extent but not randomized,and the evaluated variables were operation time,the incidence rate of POPF,and other perioperative complications.Results:The operation time showed no significant difference(P>0.05)between the two groups,but the time of duct-to-mucosa anastomosis in the m-BA group was much shorter than that in the c-BA group(P<0.001).The incidence rate of clinically relevant POPF was 12.0%(6/50)in the modified group and 10.3%(10/97)in the conventional group(P>0.05),which means that the modified anastomosis method did not cause additional pancreatic leakage.The mean length of postoperative hospital stay of the m-BA group was 23 days,and that of the c-BA group was 22 days(P>0.05).Conclusions:Compared with the conventional BA,we suggest that the modified BA is a feasible,safe,and effective operation method for P J of PD with no sacrifice of surgical quality.In the multivariate analysis,we also found that body mass

Enumeration and molecular characterization of circulating tumor cell using an in vivo capture system in squamous cell carcinoma of head and neck

Objective: Detection rate and isolation yield of circulating tumor cell (CTC) are low in squamous cell carcinoma of head and neck (SCCHN) with in vitro approaches due to limited sample volumes. In this study, we applied the CellCollector to capture CTC in vivo from peripheral blood. Methods: In total, the study included 22 cases with 37 times of detection. All of the patients were newly diagnosed with locally advanced or metastatic SCCHN, including laryngocarcinoma (40.9%, 9/22) and hypopharyngeal carcinoma (59.1%, 13/22). All patients received CTC analysis before treatment. Three patients received induction chemotherapy. Sixteen patients received surgical therapy, of which 13 patients received postoperative detection. Two patients received both induction chemotherapy and surgery treatment. Patients underwent two successive CellCollector applications 24 h before and 7 d after surgical therapy. Nine healthy volunteers were enrolled as the control group. Epidermal growth factor receptor variant type III (EGFRVIII) expression was analyzed with fluorescent dye labeled antibody. Results: With CellCollector isolation, 72.7% (16/22) of the patients were positive for >= 1 CTC (CTC; range, 1-17 cells) before treatments and 46.7% (7/15) of patients were CTC positive for >= 1 CTC (CTC; range, 1-29 cells) after surgical therapy. Moreover, the detection rate of CellCollector (82.4%, 14/17; CTC count range, 0-17) in advanced SCCHN (stage III-IV) was much higher than that in early stages (stage I-II, 40.0%, 2/5; CTC count range, 0-2) (P<0.05). EGFRVIII expression of CTC was also analyzed with fluorescence staining. One CTCEGFRVIII-positive patient was detected from six CTC-positive patients, and the positive expression of EGFRVIII was also found in the tumor tissue of this patient. Conclusions: In vivo detection of CTCs had high sensitivity in SCCHN, which might improve CTC application in clinic.

Inverse Synthetic Aperture Radar Imaging of Multi-Targets Based on Image Processing Technique

This paper presents a newmulti-targets inverse synthetic aperture radar (ISAR) imaging approach via the image segmentation processing. This method can separate multi-targets with similar velocities,and there is no strict limit on the rotational state of the targets. Firstly,the motion compensation for the completely multi-targets echo is carried out and the coarse image can be achieved with the Range-Doppler (RD) technique. Then a series of image processing methods and image segmentation processing are used to separate the echo data of each mono-target. At last,the image with high quality of each target can be achieved with the RD technique and the Range-Instantaneous-Doppler (RID) technique. ISAR imaging results of simulated and measured data validate the validity of the proposed approach.

太阳立体探测任务设想

太阳空间探测在太阳物理前沿科学问题研究和空间天气预报应用研究方面具有重要的意义.人类在60余年的太阳空间探测活动中,取得了一系列重要成果,但仍存在诸多根本性重大问题有待解决.太阳立体探测可以克服单视角观测的局限,获取全方位、多要素的物理数据,促进解决太阳物理中的重大科学问题.本文介绍了太阳内部结构和磁场起源、太阳活动机理研究、太阳活动的全日球空间天气效应和空间天气预报模式研究4个科学目标,太阳立体探测任务空间布局、系统组成和探测器总体设计,以及太阳立体探测任务的有效载荷配置和主要技术指标.

σ-LET curve obtained with heavy ions accelerated by HIRFL

σ-LET curve is one of the important factors for orbital SEU rate prediction. SEU cross sections of static random access memory (SRAM) IDT71256 were obtained with 35 MeV/u 36Ar ions and 15.14 MeV/u 136Xe ions, accelerated by Heavy Ion Research Facility in Lanzhou (HIRFL), fitted with Weibull and Lognormal function to obtain the whole σ-LET curve. The SEU rates of IDT71256 in geosynchronous and two sunsynchronous orbits were predicted with fitting parameters.