We demonstrate the fabrication of a novel magnetic nanohybrid involving the drug molecule 5 aminolevulinic acid(5-ALA)intercalated Gd-Eu layered rare-earth hydroxide(LRH)coated on magnesium ferrite particles(MgFe2O4)....We demonstrate the fabrication of a novel magnetic nanohybrid involving the drug molecule 5 aminolevulinic acid(5-ALA)intercalated Gd-Eu layered rare-earth hydroxide(LRH)coated on magnesium ferrite particles(MgFe2O4).The structure,thermostability,morphology,luminescence properties,cytotoxic effect and magnetism are investigated.The 5-ALA intercalated composite may correspond to a monolayered vertical arrangement,and the thermal stability of organics is enhanced after intercalation.The LRH precursor shows red emission of Eu^3+and the maximum emission peak of the composite is at 451 nm,corresponding to the blue emission.The detection of drug molecules can be realized through the change of luminescence.The magnetic nanohybrid shows strong magnetic sensitivity,which provides an easy and efficient way to separate 5-ALA-MgFe2O4@LGd0.95H:Eu0.05 particles from a sol or a suspension system and to carry drugs to targeted locations under an external magnetic field.The cytotoxic effect of MgFe2O4@LRH is observed with a sulforhodamine B(SRB)colorimetric assay,which has low cytotoxic effects on selected cells.The fabrication of novel bifunctional drug carriers based on LRH with magnetic and fluorescent properties has potential applications in drug detection and drug delivery.展开更多
基金supported by the Youth Top-notch Talent Training Program for Universities and Colleges under Beijing Municipality(CIT&TCD201804035)the National Natural Science Foun-dation of China(Grant No.21601016)+1 种基金the Project of Construction of Innovative Teams and Teacher Career Development for Universities and Colleges under Beiing Municipality(IDHT20180508)the Construc-tion of Scientific Research Platform(2018XK002).
文摘We demonstrate the fabrication of a novel magnetic nanohybrid involving the drug molecule 5 aminolevulinic acid(5-ALA)intercalated Gd-Eu layered rare-earth hydroxide(LRH)coated on magnesium ferrite particles(MgFe2O4).The structure,thermostability,morphology,luminescence properties,cytotoxic effect and magnetism are investigated.The 5-ALA intercalated composite may correspond to a monolayered vertical arrangement,and the thermal stability of organics is enhanced after intercalation.The LRH precursor shows red emission of Eu^3+and the maximum emission peak of the composite is at 451 nm,corresponding to the blue emission.The detection of drug molecules can be realized through the change of luminescence.The magnetic nanohybrid shows strong magnetic sensitivity,which provides an easy and efficient way to separate 5-ALA-MgFe2O4@LGd0.95H:Eu0.05 particles from a sol or a suspension system and to carry drugs to targeted locations under an external magnetic field.The cytotoxic effect of MgFe2O4@LRH is observed with a sulforhodamine B(SRB)colorimetric assay,which has low cytotoxic effects on selected cells.The fabrication of novel bifunctional drug carriers based on LRH with magnetic and fluorescent properties has potential applications in drug detection and drug delivery.
