This study was conducted to examine the impact of vehicular traffic emissions on the seasonal trends of polycyclic aromatic hydrocarbons (PAHs) concentration in particulate matter in Beijing. The PM10 and PM2.5 sample...This study was conducted to examine the impact of vehicular traffic emissions on the seasonal trends of polycyclic aromatic hydrocarbons (PAHs) concentration in particulate matter in Beijing. The PM10 and PM2.5 samples were collected at an urban site near the Third Ring Road in Beijing, China, from July 2009 to March 2010. Individual PAH concentrations at urban traffic site ranged from n.d. (below the detection limit, 0.2 ng/m3) to 558.49 ng/m3 of benzo(b)fluoranthene in PM10 samples and from n.d. to 177.93 ng/m3 also for benzo(b)fluoranthene in PM2.5 samples. Seasonal variations of PAHs compounds indicated that PAHs concentration in autumn and winter was higher than those in spring and summer. Results of PCA give four and five significant factors, which could explain 83.1% of the variation for PM2.5 and 85.3% of the variation for PM10, respectively.展开更多
Aging is an essential part for production of the most distilled spirits.Aged spirits smell and taste more harmonious and commonly have higher antioxidant capacity in vitro than fresh spirits.However,it is unclear how ...Aging is an essential part for production of the most distilled spirits.Aged spirits smell and taste more harmonious and commonly have higher antioxidant capacity in vitro than fresh spirits.However,it is unclear how aged spirits influence intestinal microbiota and host metabolism,which play important role in the development and progression of alcoholic liver disease(ALD).Baijiu is a traditional Chinese alcoholic beverage.Freshly distilled baijiu needs to be aged for at least 1 year.Here,we built an animal model through oral gavage by fresh baijiu,10-year-old baijiu,20-year-old baijiu,ethanol and water.Our results showed that mice treated with aged baijiu had lower degrees of liver injury than that of fresh baijiu as revealed by the phenotypic,biochemical and histologic analyses.In addition,significant different gut microbiota structures were observed between mice treated with aged baijiu and fresh baijiu.Further co-occurrence network showed that the aged baijiu groups had more complex microbial interaction than fresh baijiu group.By metabolomics,we observed aged baijiu and fresh baijiu intervention resulted in distinct serum metabolome.Sixty-four metabolites showed significant alteration among different interventions.Further metabolic pathway analysis based on these differential metabolites revealed 7 pathways were significantly impacted.A total of 13 metabolites were involved in these pathways,including 8 amino acids,4 organic acids and 1 carbohydrate.Our results filled the gap of how aged spirits affect gut microbiota and host metabolism and provided supporting evidence that the aged spirits may have less effect on liver than fresh spirits.展开更多
文摘This study was conducted to examine the impact of vehicular traffic emissions on the seasonal trends of polycyclic aromatic hydrocarbons (PAHs) concentration in particulate matter in Beijing. The PM10 and PM2.5 samples were collected at an urban site near the Third Ring Road in Beijing, China, from July 2009 to March 2010. Individual PAH concentrations at urban traffic site ranged from n.d. (below the detection limit, 0.2 ng/m3) to 558.49 ng/m3 of benzo(b)fluoranthene in PM10 samples and from n.d. to 177.93 ng/m3 also for benzo(b)fluoranthene in PM2.5 samples. Seasonal variations of PAHs compounds indicated that PAHs concentration in autumn and winter was higher than those in spring and summer. Results of PCA give four and five significant factors, which could explain 83.1% of the variation for PM2.5 and 85.3% of the variation for PM10, respectively.
基金supported by the National Natural Science Foundation of China(Grant No.22108095)Beijing Advanced Innovation Center for Food Nutrition and Human Health of the Beijing Technology and Business University(Grant No.20182033).
文摘Aging is an essential part for production of the most distilled spirits.Aged spirits smell and taste more harmonious and commonly have higher antioxidant capacity in vitro than fresh spirits.However,it is unclear how aged spirits influence intestinal microbiota and host metabolism,which play important role in the development and progression of alcoholic liver disease(ALD).Baijiu is a traditional Chinese alcoholic beverage.Freshly distilled baijiu needs to be aged for at least 1 year.Here,we built an animal model through oral gavage by fresh baijiu,10-year-old baijiu,20-year-old baijiu,ethanol and water.Our results showed that mice treated with aged baijiu had lower degrees of liver injury than that of fresh baijiu as revealed by the phenotypic,biochemical and histologic analyses.In addition,significant different gut microbiota structures were observed between mice treated with aged baijiu and fresh baijiu.Further co-occurrence network showed that the aged baijiu groups had more complex microbial interaction than fresh baijiu group.By metabolomics,we observed aged baijiu and fresh baijiu intervention resulted in distinct serum metabolome.Sixty-four metabolites showed significant alteration among different interventions.Further metabolic pathway analysis based on these differential metabolites revealed 7 pathways were significantly impacted.A total of 13 metabolites were involved in these pathways,including 8 amino acids,4 organic acids and 1 carbohydrate.Our results filled the gap of how aged spirits affect gut microbiota and host metabolism and provided supporting evidence that the aged spirits may have less effect on liver than fresh spirits.
