A new strategy to induce vesicle fusion has been developed by employing pillar[5]arene derivatives that were channel-like and were prepared by appending side chains onto pillar[5]arenes backbones.The channels feature ...A new strategy to induce vesicle fusion has been developed by employing pillar[5]arene derivatives that were channel-like and were prepared by appending side chains onto pillar[5]arenes backbones.The channels feature with hydrophilic negatively and positively charged groups at both ends and hydrophobic Trp residues at the outer surface,which endows the channels with amphiphilicity.The zwitterionic amphiphilic channels could spontaneously incorporate into the bilayer membranes of lipid vesicles to induce vesicle fusion driven by the electrostatic interactions between negatively charged and positively charged groups.展开更多
基金the National Natural Science Foundation of China(NSFC,Nos.21921003 and 21971046)the Science and Technology Commission of Shanghai Municipality(STCSM,No.22JC1403700).
文摘A new strategy to induce vesicle fusion has been developed by employing pillar[5]arene derivatives that were channel-like and were prepared by appending side chains onto pillar[5]arenes backbones.The channels feature with hydrophilic negatively and positively charged groups at both ends and hydrophobic Trp residues at the outer surface,which endows the channels with amphiphilicity.The zwitterionic amphiphilic channels could spontaneously incorporate into the bilayer membranes of lipid vesicles to induce vesicle fusion driven by the electrostatic interactions between negatively charged and positively charged groups.
