Organic fluorine compounds are ubiquitous and pivotally important organic molecules,yet their activation and transformation have long been a formidable challenge due to the high energy and low reactivity of C-F bonds....Organic fluorine compounds are ubiquitous and pivotally important organic molecules,yet their activation and transformation have long been a formidable challenge due to the high energy and low reactivity of C-F bonds.Organic electrosynthesis,an environmentally benign synthetic method in organic chemistry,enables a myriad of chemical transformations without the need for external redox reagents.In recent years,organic electrochemistry has emerged as a powerful tool for achieving the activation and transformation of C-F bonds in fluorine-containing compounds.This review aims to succinctly recapitulate the latest advancements in the electrochemical defluorinative transformations of C-F bonds and to delve into the reaction design,mechanistic insights,and developmental prospects ofthese methods.展开更多
基金the Natural Science Foundation of Zhejiang Province(LQ22B020005,LZ22B020003)the National Natural Science Foundation of China(22101201,22071171)for financial support of this work.
文摘Organic fluorine compounds are ubiquitous and pivotally important organic molecules,yet their activation and transformation have long been a formidable challenge due to the high energy and low reactivity of C-F bonds.Organic electrosynthesis,an environmentally benign synthetic method in organic chemistry,enables a myriad of chemical transformations without the need for external redox reagents.In recent years,organic electrochemistry has emerged as a powerful tool for achieving the activation and transformation of C-F bonds in fluorine-containing compounds.This review aims to succinctly recapitulate the latest advancements in the electrochemical defluorinative transformations of C-F bonds and to delve into the reaction design,mechanistic insights,and developmental prospects ofthese methods.
