The current study sought to investigate the potential protective action of curcumin against interleukin-6-induced injury in rat hippocampal neurons. The results revealed that interleukin-6 induced typical cellular inj...The current study sought to investigate the potential protective action of curcumin against interleukin-6-induced injury in rat hippocampal neurons. The results revealed that interleukin-6 induced typical cellular injury, such as the swelling of cell bodies and increased Ca^2＋ concentration. After administration of curcumin, interleukin-6-induced neurons recovered to a normal state, and the fluorescence intensity of Ca^2＋ gradually returned to normal. These findings suggest that curcumin exerts a protective effect on hippocampal neurons of rats. In addition, our results suggest that the protective effect of curcumin involves prevention of the rapid Ca^2＋ influx induced by interleukin-6, which maintains Ca^2＋ homeostasis.展开更多
基金the Natural Science Foundation of Guangdong Province,No. 06105246, 9151040701000Science and Technology Foundation of Guangzhou,No. 2010Y1-C291+1 种基金Science and Technology Foundation of Guangdong Province,No. 2010B030700016, 2008A030201003Leading Academic Discipline Program,211 Project for Jinan University (The 3 rd Phase)
文摘The current study sought to investigate the potential protective action of curcumin against interleukin-6-induced injury in rat hippocampal neurons. The results revealed that interleukin-6 induced typical cellular injury, such as the swelling of cell bodies and increased Ca^2＋ concentration. After administration of curcumin, interleukin-6-induced neurons recovered to a normal state, and the fluorescence intensity of Ca^2＋ gradually returned to normal. These findings suggest that curcumin exerts a protective effect on hippocampal neurons of rats. In addition, our results suggest that the protective effect of curcumin involves prevention of the rapid Ca^2＋ influx induced by interleukin-6, which maintains Ca^2＋ homeostasis.
