Non-alcoholic fatty liver disease(NAFLD)is characterized by the abnormal buildup of lipids in the liver tissue.Non-alcoholic fatty liver(NAFL)may progress to non-alcoholic steatohepatitis.Triglycerides in the liver ca...Non-alcoholic fatty liver disease(NAFLD)is characterized by the abnormal buildup of lipids in the liver tissue.Non-alcoholic fatty liver(NAFL)may progress to non-alcoholic steatohepatitis.Triglycerides in the liver can originate from various sources,including de novo lipogenesis(DNL).Research indicates that DNL significantly escalates in NAFLD,worsening steatosis.However,the precise regulatory mechanism of DNL in the development of this disease is not fully understood.Therefore,the targeted reduction of DNL could be a crucial therapeutic strategy.Currently,numerous pharmaceutical agents targeting DNL have been developed,attracting significant attention.This review examines the mechanism of DNL upregulation in NAFLD,assessing its potential as a therapeutic target for hepatic steatosis.Furthermore,we thoroughly examine hepatocellular lipotoxicity and provide an extensive review of the application and limitations of relevant therapeutic drugs,with a focus on key enzymes involved in DNL.The implementation of these pharmacological strategies is expected to significantly improve the management and overall outcomes for patients with NAFLD.展开更多
An onboard facility shows promise in efficiently converting floating plastics into valuable products,such as methanol,negating the need for regional transport and land-based treatment.Gasification presents an effectiv...An onboard facility shows promise in efficiently converting floating plastics into valuable products,such as methanol,negating the need for regional transport and land-based treatment.Gasification presents an effective means of processing plastics,requiring their transformation into gasification-compatible feedstock,such as hydrochar.This study explores hydrochar composition modeling,utilizing advanced algorithms and rigorous analyses to unravel the intricacies of elemental composition ratios,identify influential factors,and optimize hydrochar production processes.The investigation begins with decision tree modeling,which successfully captures relationships but encounters overfitting challenges.Nevertheless,the decision tree vote analysis,particularly for the H/C ratio,yielding an impressive R2 of 0.9376.Moreover,the research delves into the economic feasibility of the marine plastics-to-methanol process.Varying payback periods,driven by fluctuating methanol prices observed over a decade(ranging from 3.3 to 7 yr for hydrochar production plants),are revealed.Onboard factories emerge as resilient solutions,capitalizing on marine natural gas resources while striving for near-net-zero emissions.This comprehensive study advances our understanding of hydrochar composition and offers insights into the economic potential of environmentally sustainable marine plastics-to-methanol processes.展开更多
基金the National Natural Science Foundation of China(82325008).
文摘Non-alcoholic fatty liver disease(NAFLD)is characterized by the abnormal buildup of lipids in the liver tissue.Non-alcoholic fatty liver(NAFL)may progress to non-alcoholic steatohepatitis.Triglycerides in the liver can originate from various sources,including de novo lipogenesis(DNL).Research indicates that DNL significantly escalates in NAFLD,worsening steatosis.However,the precise regulatory mechanism of DNL in the development of this disease is not fully understood.Therefore,the targeted reduction of DNL could be a crucial therapeutic strategy.Currently,numerous pharmaceutical agents targeting DNL have been developed,attracting significant attention.This review examines the mechanism of DNL upregulation in NAFLD,assessing its potential as a therapeutic target for hepatic steatosis.Furthermore,we thoroughly examine hepatocellular lipotoxicity and provide an extensive review of the application and limitations of relevant therapeutic drugs,with a focus on key enzymes involved in DNL.The implementation of these pharmacological strategies is expected to significantly improve the management and overall outcomes for patients with NAFLD.
基金financial support from the Marie Skłodowska Curie Actions Fellowships by The European Research Executive Agency,Belguim(Grant Nos.H2020-MSCA-IF-2020 and 101025906)。
文摘An onboard facility shows promise in efficiently converting floating plastics into valuable products,such as methanol,negating the need for regional transport and land-based treatment.Gasification presents an effective means of processing plastics,requiring their transformation into gasification-compatible feedstock,such as hydrochar.This study explores hydrochar composition modeling,utilizing advanced algorithms and rigorous analyses to unravel the intricacies of elemental composition ratios,identify influential factors,and optimize hydrochar production processes.The investigation begins with decision tree modeling,which successfully captures relationships but encounters overfitting challenges.Nevertheless,the decision tree vote analysis,particularly for the H/C ratio,yielding an impressive R2 of 0.9376.Moreover,the research delves into the economic feasibility of the marine plastics-to-methanol process.Varying payback periods,driven by fluctuating methanol prices observed over a decade(ranging from 3.3 to 7 yr for hydrochar production plants),are revealed.Onboard factories emerge as resilient solutions,capitalizing on marine natural gas resources while striving for near-net-zero emissions.This comprehensive study advances our understanding of hydrochar composition and offers insights into the economic potential of environmentally sustainable marine plastics-to-methanol processes.
