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Salidroside reduces tau hyperphosphorylation via up-regulating GSK-3β phosphorylation in a tau transgenic Drosophila model of Alzheimer’s disease 被引量:15
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作者 Bei Zhang qiongqiong li +2 位作者 Xingkun Chu Suya Sun Shengdi Chen 《Translational Neurodegeneration》 SCIE CAS 2016年第1期165-170,共6页
Background:Alzheimer’s disease(AD)is an age-related and progressive neurodegenerative disease that causes substantial public health care burdens.Intensive efforts have been made to find effective and safe treatment a... Background:Alzheimer’s disease(AD)is an age-related and progressive neurodegenerative disease that causes substantial public health care burdens.Intensive efforts have been made to find effective and safe treatment against AD.Salidroside(Sal)is the main effective component of Rhodiola rosea L.,which has several pharmacological activities.The objective of this study was to investigate the efficacy of Sal in the treatment of AD transgenic Drosophila and the associated mechanisms.Methods:We used tau transgenic Drosophila line(TAU)in which tau protein is expressed in the central nervous system and eyes by the Gal4/UAS system.After feeding flies with Sal,the lifespan and locomotor activity were recorded.We further examined the appearance of vacuoles in the mushroom body using immunohistochemistry,and detected the levels of total glycogen synthase kinase 3β(t-GSK-3β),phosphorylated GSK-3β(p-GSK-3β),t-tau and p-tau in the brain by western blot analysis.Results:Our results showed that the longevity was improved in salidroside-fed Drosophila groups as well as the locomotor activity.We also observed less vacuoles in the mushroom body,upregulated level of p-GSK-3βand downregulated p-tau following Sal treatment.Conclusion:Our data presented the evidence that Sal was capable of reducing the neurodegeneration in tau transgenic Drosophila and inhibiting neuronal loss.The neuroprotective effects of Sal were associated with its up-regulation of the p-GSK-3βand down-regulation of the p-tau. 展开更多
关键词 Alzheimer’s disease SALIDROSIDE DROSOPHILA Glycogen synthase kinase TAU
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In-situ imaging of strain-induced enhancement of hydrogen evolution activity on the extruded MoO_(2)sheets 被引量:1
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作者 Mansheng liao Qiaomei Zhu +3 位作者 Shuhua li qiongqiong li Ziting Tao Yongchun Fu 《Nano Research》 SCIE EI CSCD 2023年第4期5419-5426,共8页
Strain engineering is a useful strategy for modifying the catalytic activity of electrocatalysts.However,in-situ visual characterization of the strain effect on the catalytic activity at nanoscale remains a huge chall... Strain engineering is a useful strategy for modifying the catalytic activity of electrocatalysts.However,in-situ visual characterization of the strain effect on the catalytic activity at nanoscale remains a huge challenge.Herein,we performed in-situ electrochemical scanning tunneling microscopy(EC-STM)imaging measurements at the local strained regions of extruded singlecrystal molybdenum dioxide(MoO_(2))sheets with combination of current noise analysis(n-EC-STM).The intensity-enhanced noise was observed at the local strained region compared to the unstrained regions in the same frame,which reveals the positive effect of compressive strain on the hydrogen evolution reaction(HER)activity of MoO_(2)provided that the intensity of noise is positively correlated with catalytic HER Faradic current.Therefore,we clearly“see”the strain-induced enhancement of HER activity of MoO_(2)at nanoscale by means of noise visualization.This work extends the visual characterization of strain engineering in electrocatalysis and related fields. 展开更多
关键词 strain engineering visual characterization electrochemical scanning tunneling microscope noise enhancement
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