目的观察参麦注射液联合高压氧治疗突发性聋(SD)的临床疗效,探讨其治疗机制,为临床治疗提供理论基础。方法选取2015年1月-2016年3月于湖北省十堰市太和医院耳鼻喉科收治的206例SD患者按入院先后顺序随机均分为观察组和参麦组,观察组用...目的观察参麦注射液联合高压氧治疗突发性聋(SD)的临床疗效,探讨其治疗机制,为临床治疗提供理论基础。方法选取2015年1月-2016年3月于湖北省十堰市太和医院耳鼻喉科收治的206例SD患者按入院先后顺序随机均分为观察组和参麦组,观察组用地塞米松联合长春西汀等常规治疗,参麦组在该治疗基础上静脉滴注参麦注射液并联合高压氧治疗。记录患者听性脑干反应(ABR)反应阈,并记录80 d B n HL短声刺激时Ⅰ~Ⅵ波的潜伏期,分析静脉血氧饱和度(SvO_2),无创经颅多普勒记录两组患者局部脑血流(RCBF),统计两组患者治疗前后耳鸣和眩晕残存率、愈显率及总有效率。结果两组ABRⅡ波、Ⅲ波潜伏期、Ⅰ~Ⅲ波间期、ABR反应阈、SvO_2及RCBF比较有差异(P<0.05),参麦组耳鸣和眩晕残存率降低,愈显率为79.61%、总有效率为98.05%,与观察组比较,差异有统计学意义(P<0.05)。结论参麦注射液扩管作用可提高耳蜗受损组织血流量,高压氧可提高SvO_2,增加外淋巴氧压,促进耳蜗、前庭神经的修复,两者合用提高疗效。展开更多
Objective:To develop a reversed-phase high-performance liquid chromatography method for the quantification of major ginsenosides in red ginseng(RG,the steamed and dried root of the cultivar of Panax ginseng C.A.Mey).M...Objective:To develop a reversed-phase high-performance liquid chromatography method for the quantification of major ginsenosides in red ginseng(RG,the steamed and dried root of the cultivar of Panax ginseng C.A.Mey).Methods:A feasible method was developed in strict accordance with chromatographic properties of eight ginsenosides.Their contents could be unveiled with conventional external standard method,or as an alternative,using ginsenoside Rg1 as the single reference standard by means of seven conversion factors.Those parameters had been validated on different chromatographic columns and instruments.Results:Twenty-one batches of RG samples were determined.In addition,the chromatograms of RG and confusing species,including Panax ginseng,Panax quinquefolium,and Panax notoginseng,were apparently different.Conclusions:The method was proved to be efficient for the quality control of RG.展开更多
Objective: Establish a quick, precise and specific method to determine whether the moutan cortex obtained from market is processed with sulfur; provide a reliable method for the scientific evaluation.Methods: Three me...Objective: Establish a quick, precise and specific method to determine whether the moutan cortex obtained from market is processed with sulfur; provide a reliable method for the scientific evaluation.Methods: Three methods, including acid-base titration method, high-performance liquid-chromatography(HPLC) method, and ultraperformance liquid chromatography coupled with time-of-flight mass spectrometry(UHPLC-TOF-MS) method were used to detect whether30 batches of samples were fumigated with sulfur.Results: The results of three methods were substantially the same. Fifteen batches were identified to have been processed with sulfur fumigation, while others were not.Conclusions: The HPLC method was found to be most appropriate for the determination of sulfur fumigation for moutan cortex.展开更多
文摘目的观察参麦注射液联合高压氧治疗突发性聋(SD)的临床疗效,探讨其治疗机制,为临床治疗提供理论基础。方法选取2015年1月-2016年3月于湖北省十堰市太和医院耳鼻喉科收治的206例SD患者按入院先后顺序随机均分为观察组和参麦组,观察组用地塞米松联合长春西汀等常规治疗,参麦组在该治疗基础上静脉滴注参麦注射液并联合高压氧治疗。记录患者听性脑干反应(ABR)反应阈,并记录80 d B n HL短声刺激时Ⅰ~Ⅵ波的潜伏期,分析静脉血氧饱和度(SvO_2),无创经颅多普勒记录两组患者局部脑血流(RCBF),统计两组患者治疗前后耳鸣和眩晕残存率、愈显率及总有效率。结果两组ABRⅡ波、Ⅲ波潜伏期、Ⅰ~Ⅲ波间期、ABR反应阈、SvO_2及RCBF比较有差异(P<0.05),参麦组耳鸣和眩晕残存率降低,愈显率为79.61%、总有效率为98.05%,与观察组比较,差异有统计学意义(P<0.05)。结论参麦注射液扩管作用可提高耳蜗受损组织血流量,高压氧可提高SvO_2,增加外淋巴氧压,促进耳蜗、前庭神经的修复,两者合用提高疗效。
基金supported by the National Natural Science Foundation of China(No.81530095,81673591)。
文摘Objective:To develop a reversed-phase high-performance liquid chromatography method for the quantification of major ginsenosides in red ginseng(RG,the steamed and dried root of the cultivar of Panax ginseng C.A.Mey).Methods:A feasible method was developed in strict accordance with chromatographic properties of eight ginsenosides.Their contents could be unveiled with conventional external standard method,or as an alternative,using ginsenoside Rg1 as the single reference standard by means of seven conversion factors.Those parameters had been validated on different chromatographic columns and instruments.Results:Twenty-one batches of RG samples were determined.In addition,the chromatograms of RG and confusing species,including Panax ginseng,Panax quinquefolium,and Panax notoginseng,were apparently different.Conclusions:The method was proved to be efficient for the quality control of RG.
文摘Objective: Establish a quick, precise and specific method to determine whether the moutan cortex obtained from market is processed with sulfur; provide a reliable method for the scientific evaluation.Methods: Three methods, including acid-base titration method, high-performance liquid-chromatography(HPLC) method, and ultraperformance liquid chromatography coupled with time-of-flight mass spectrometry(UHPLC-TOF-MS) method were used to detect whether30 batches of samples were fumigated with sulfur.Results: The results of three methods were substantially the same. Fifteen batches were identified to have been processed with sulfur fumigation, while others were not.Conclusions: The HPLC method was found to be most appropriate for the determination of sulfur fumigation for moutan cortex.
