Aberrant tumor blood vessels are prone to propel the malignant progression of tumors,and targeting abnormal metabolism of tumor endothelial cells emerges as a promising option to achieve vascular normalization and ant...Aberrant tumor blood vessels are prone to propel the malignant progression of tumors,and targeting abnormal metabolism of tumor endothelial cells emerges as a promising option to achieve vascular normalization and antagonize tumor progression.Herein,we demonstrated that salvianic acid A(SAA)played a pivotal role in contributing to vascular normalization in the tumor-bearing mice,thereby improving delivery and effectiveness of the chemotherapeutic agent.SAA was capable of inhibiting glycolysis and strengthening endothelial junctions in the human umbilical vein endothelial cells(HUVECs)exposed to hypoxia.Mechanistically,SAA was inclined to directly bind to the glycolytic enzyme PKM2,leading to a dramatic decrease in endothelial glycolysis.More importantly,SAA improved the endothelial integrity via activating theβ-Catenin/Claudin-5 signaling axis in a PKM2-dependent manner.Our findings suggest that SAA may serve as a potent agent for inducing tumor vascular normalization.展开更多
China＇s dairy industry has experienced rapid expansion in recent years, with an average annual growth rate of 23.8 percent from 2000 to 2006. However, there exists a serious geographical distribution imbalance in mil...China＇s dairy industry has experienced rapid expansion in recent years, with an average annual growth rate of 23.8 percent from 2000 to 2006. However, there exists a serious geographical distribution imbalance in milk production and consumption. Approximately 85 percent of China＇s milk is produced in northern China, where 40 percent of the country＇s population reside. In contrast, only about 15 percent of the milk is produced in China＇s south, where 60percent of China＇s population reside. This has resulted in a significant gap between milk production and consumption in southern China and this gap is expected to rise. This paper considers China＇s milk demand and supply situation, analyzes the likely potential for China to expand its milk production and explores options for meeting milk demand-supply shortages. Policy and trade implications are discussed.展开更多
基金This work was financially supported by the projects of National Natural Science Foundation of China(82003991,82101844,and 82304953)Natural Science Foundation of Jiangsu Province(BK20230744,China)+1 种基金Jiangsu Specially Appointed Professorship Foundation(013038021001,China)Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX22-2045 and KYCX23-2038,China).
文摘Aberrant tumor blood vessels are prone to propel the malignant progression of tumors,and targeting abnormal metabolism of tumor endothelial cells emerges as a promising option to achieve vascular normalization and antagonize tumor progression.Herein,we demonstrated that salvianic acid A(SAA)played a pivotal role in contributing to vascular normalization in the tumor-bearing mice,thereby improving delivery and effectiveness of the chemotherapeutic agent.SAA was capable of inhibiting glycolysis and strengthening endothelial junctions in the human umbilical vein endothelial cells(HUVECs)exposed to hypoxia.Mechanistically,SAA was inclined to directly bind to the glycolytic enzyme PKM2,leading to a dramatic decrease in endothelial glycolysis.More importantly,SAA improved the endothelial integrity via activating theβ-Catenin/Claudin-5 signaling axis in a PKM2-dependent manner.Our findings suggest that SAA may serve as a potent agent for inducing tumor vascular normalization.
文摘China＇s dairy industry has experienced rapid expansion in recent years, with an average annual growth rate of 23.8 percent from 2000 to 2006. However, there exists a serious geographical distribution imbalance in milk production and consumption. Approximately 85 percent of China＇s milk is produced in northern China, where 40 percent of the country＇s population reside. In contrast, only about 15 percent of the milk is produced in China＇s south, where 60percent of China＇s population reside. This has resulted in a significant gap between milk production and consumption in southern China and this gap is expected to rise. This paper considers China＇s milk demand and supply situation, analyzes the likely potential for China to expand its milk production and explores options for meeting milk demand-supply shortages. Policy and trade implications are discussed.
