Endoplasmic reticulum(ER)stress is a procedure that results from increased protein release or improper ER protein folding,which is emerging as a possible driver of pathological conditions such as cancer,cardiometaboli...Endoplasmic reticulum(ER)stress is a procedure that results from increased protein release or improper ER protein folding,which is emerging as a possible driver of pathological conditions such as cancer,cardiometabolic diseases,rheumatic disease,and neurodegenerative diseases.f,2 Activating transcription factor 4(ATF4),which is considered the primary controller of the cellular reaction when subjected to external stress,3 plays a vital role in amino acid metabolism,differentiation,metastasis,angiogenesis,and stress-related oxidative resistance.展开更多
基金supported by the China Postdoctoral Science Foundation (No.2021M691469,2022M721526)the Guangdong Basic and Applied Basic Research Foundation (China) (No.2020A1515110872,2021A1515111220,2022A1515110165)+4 种基金the Guangzhou Science and Technology Plan Project (Guangdong,China) (No.202201011554)the National Natural Science Foundation of China (No.82102925,82303366)the Key-Area Research and Development Program of Guangdong Province,China (No.2022B0303020003)the President Foundation of Nanfang Hospital,Southern Medical University (No.2020C007)the College Students'Innovative Entrepreneurial Training Plan Program (No.S202312121115).
文摘Endoplasmic reticulum(ER)stress is a procedure that results from increased protein release or improper ER protein folding,which is emerging as a possible driver of pathological conditions such as cancer,cardiometabolic diseases,rheumatic disease,and neurodegenerative diseases.f,2 Activating transcription factor 4(ATF4),which is considered the primary controller of the cellular reaction when subjected to external stress,3 plays a vital role in amino acid metabolism,differentiation,metastasis,angiogenesis,and stress-related oxidative resistance.
