Review of the Tuned Mass Damper Inerter(TMDI)in Energy Harvesting and Vibration Control:Designs,Analysis and Applications

Tuned mass damper inerter(TMDI)is a device that couples traditional tuned mass dampers(TMD)with an inertial device.The inertial device produces resistance proportional to the relative acceleration at its two ends through its“inertial”constant.Due to its unique mechanical properties,TMDI has received widespread attention and application in the past twenty years.As different configurations are required in different practical situations,TMDI is still active in the research on vibration control and energy harvesting in structures.This paper provides a comprehensive review of the research status of TMDI.This work first examines the generation and important vibration control characteristics of TMDI.Then,the energy harvesting performance of electromagnetic tuned mass damper inerter(EM-TMDI)is discussed.This work emphasizes the formation of a passive dynamic vibration absorber by coupling traditional TMD with inertial devices.This paper also summarizes the design and implementation of optimal vibration control and energy harvesting for TMDI.Furthermore,this paper details the applications of TMDI in the fields of bridges and building engineering.Finally,this paper summarizes the necessity of research on tuned mass-damper-inertia,the challenges faced currently,and future research directions,such as control of parameters in electromagnetic energy harvesting TMDI systems and low-cost TMDI.

Near-Infrared Light-Activatable Melanized Paclitaxel Nano-Self-Assemblies for Synergistic Anti-tumor Therapy

Building self-assembly nanostructures is an important way to overcome the limitations of paclitaxel in tumor therapy.However,this strategy is also faced with challenges,such as difficulties in efficient release and the potential for drug resistance.Herein,we developed a near-infrared light-activatable melanized paclitaxel self-assembly nanoparticles for synergistic anti-tumor therapy.In this strategy,paclitaxel dimer prodrugs were synthesized and paclitaxel nanoparticles were obtained through self-assembly.Finally,the paclitaxel dimer nanoparticles were capped with polydopamine(PDA,melanoidin)and human serum albumin(HSA).The disulfide bonds in paclitaxel dimeric prodrug specifically respond to high concentrations of glutathione(GSH)and reactive oxygen species(ROS)in tumor cells.PDA enhances the biocompatibility of the drug molecules and imparts near-infrared photothermal conversion capability to the nano-self-assemblies.Both the in vitro and in vivo experiments demonstrated that this paclitaxel nanoprodrug exhibited enhanced tumor therapeutic efficacy under near-infrared light irradiation.