Non-exosomal non-coding RNAs(non-exo-ncRNAs)and exosomal ncRNAs(exo-ncRNAs)have been associated with the pathological development of myocardial infarction(MI).Accordingly,this analytical review provides an overview of...Non-exosomal non-coding RNAs(non-exo-ncRNAs)and exosomal ncRNAs(exo-ncRNAs)have been associated with the pathological development of myocardial infarction(MI).Accordingly,this analytical review provides an overview of current MI studies on the role of plasma non-exo/exo-ncRNAs.We summarize the features and crucial roles of ncRNAs and reveal their novel biological correlations via bioinformatics analysis.The following contributions are made:(1)we comprehensively describe the expression profile,competing endogenous RNA(ceRNA)network,and“pre-necrotic”biomarkers of non-exo/exo-ncRNAs for MI;(2)functional enrichment analysis indicates that the target genes of ncRNAs are enriched in the regulation of apoptotic signaling pathway and cellular response to chemical stress,etc.;(3)we propose an updated and comprehensive view on the mechanisms,pathophysiology,and biomarker roles of non-exo/exo-ncRNAs in MI,thereby providing a theoretical basis for the clinical management of MI.展开更多
基金National Natural Science Foundation of China(Nos.81860073,81760074,and 82160439)Yunnan Provincial Department of Science and Technology(No.202001AT070039)+10 种基金the Yunnan Health Training Project of High-Level Talents(No.H-2018032)the 100 Young and Middle-aged Academic and Technical Backbones of Kunming Medical University(No.60118260106)the Young Talents of Yunnan Thousand Talents Plan(Nos.YNQR-QNRC-2019-006 and RLQN20200002)the Graduate Student Innovation Fund of Kunming Medical University(No.2022S035)the National Natural Science Foundation of China(Nos.81860073,81760074,and 82160439)Yunnan Provincial Department of Science and Technology(No.202001AT070039)Yunnan Health Training Project of High-Level Talents(No.H-2018032)100 Young and Middle-aged Academic and Technical Backbones of Kunming Medical University(No.60118260106)Young Talents of Yunnan Thousand Talents Plan(Nos.YNQR-QNRC-2019-006 and RLQN20200002)Graduate Student Innovation Fund of Kunming Medical University(No.2022S035)Clinical Medical Center for Cardiovascular and Cerebrovascular Disease of Yunnan Province(No.ZX2019-03-01),China.
文摘Non-exosomal non-coding RNAs(non-exo-ncRNAs)and exosomal ncRNAs(exo-ncRNAs)have been associated with the pathological development of myocardial infarction(MI).Accordingly,this analytical review provides an overview of current MI studies on the role of plasma non-exo/exo-ncRNAs.We summarize the features and crucial roles of ncRNAs and reveal their novel biological correlations via bioinformatics analysis.The following contributions are made:(1)we comprehensively describe the expression profile,competing endogenous RNA(ceRNA)network,and“pre-necrotic”biomarkers of non-exo/exo-ncRNAs for MI;(2)functional enrichment analysis indicates that the target genes of ncRNAs are enriched in the regulation of apoptotic signaling pathway and cellular response to chemical stress,etc.;(3)we propose an updated and comprehensive view on the mechanisms,pathophysiology,and biomarker roles of non-exo/exo-ncRNAs in MI,thereby providing a theoretical basis for the clinical management of MI.
