The progression of many diseases is accompanied by inflammation,in which inflammasomes play an important role.Inflammasomes are large multimolecular complexes present in the cytosol of stimulated immune cells,which me...The progression of many diseases is accompanied by inflammation,in which inflammasomes play an important role.Inflammasomes are large multimolecular complexes present in the cytosol of stimulated immune cells,which mediate the activation of caspase-1 and the secretion of cytokines,leading to cellular pyroptosis.During this process,metabolic regulation of the inflammasome is gaining increasing attention in this field.This review focuses on a major inflammasome,NOD-,LRR-and pyrin domain-containing protein 3(NLRP3),and discusses the role and significance of its metabolic regulation.展开更多
基金This work was supported by the National Natural Science Foundation of China(81930042,81730047,31670926,and 31800759)the National Key Research and Development Program of China(2018YFC1105203 and 2016YFC1100204).
文摘The progression of many diseases is accompanied by inflammation,in which inflammasomes play an important role.Inflammasomes are large multimolecular complexes present in the cytosol of stimulated immune cells,which mediate the activation of caspase-1 and the secretion of cytokines,leading to cellular pyroptosis.During this process,metabolic regulation of the inflammasome is gaining increasing attention in this field.This review focuses on a major inflammasome,NOD-,LRR-and pyrin domain-containing protein 3(NLRP3),and discusses the role and significance of its metabolic regulation.
