In practical multi-sensor information fusion systems, there exists uncertainty about the network structure, active state of sensors, and information itself （including fuzziness, randomness, incompleteness as well as ...In practical multi-sensor information fusion systems, there exists uncertainty about the network structure, active state of sensors, and information itself （including fuzziness, randomness, incompleteness as well as roughness, etc）. Hence it requires investigating the problem of uncertain information fusion. Robust learning algorithm which adapts to complex environment and the fuzzy inference algorithm which disposes fuzzy information are explored to solve the problem. Based on the fusion technology of neural networks and fuzzy inference algorithm, a multi-sensor uncertain information fusion system is modeled. Also RANFIS learning algorithm and fusing weight synthesized inference algorithm are developed from the ANFIS algorithm according to the concept of robust neural networks. This fusion system mainly consists of RANFIS confidence estimator, fusing weight synthesized inference knowledge base and weighted fusion section. The simulation result demonstrates that the proposed fusion model and algorithm have the capability of uncertain information fusion, thus is obviously advantageous compared with the conventional Kalman weighted fusion algorithm.展开更多
Plant-derived microRNAs have recently been reported to function in human blood and tissues. Controversy was immediately raised due to possible contamination and the lack of large sample sizes. Here, we report thousand...Plant-derived microRNAs have recently been reported to function in human blood and tissues. Controversy was immediately raised due to possible contamination and the lack of large sample sizes. Here, we report thousands of unique small RNAs derived from traditional Chinese medicine(TCM) herbs found in human blood cells and mouse lung tissues using a large-scale analysis.We extracted small RNAs from decoctions of 10 TCM plants(Ban Zhi Lian, Chai Hu, Chuan Xin Lian, Di Ding Zi Jin, Huang Qin, Jin Yin Hua, Lian Qiao, Pu Gong Ying, Xia Ku Cao, and Yu Xing Cao) and obtained millions of RNA sequences from each herb. We also obtained RNA-Seq data from the blood cells of humans who consumed herbal decoctions and from the lung tissues of mice administered RNAs from herbal decoctions via oral gavage. We identified thousands of unique small RNA sequences in human blood cells and mouse lung tissues. Some of these identified small RNAs from Chuan Xin Lian and Hong Jing Tian could be mapped to the genomes of the herbs, confirming their TCM plant origin. Small RNAs derived from herbs regulate mammalian gene expression in a sequence-specific manner, and thus are a superior novel class of herbal drug components that hold great potential as oral gene-targeted therapeutics, highlighting the important role of herbgenomics in their development.展开更多
To the Editor:Asthma is an abnormal chronic inflammatory disease characterized by the involvement of a complex network of cells.Barrier epithelial cells(ECs)represent the first line of defense and express pattern reco...To the Editor:Asthma is an abnormal chronic inflammatory disease characterized by the involvement of a complex network of cells.Barrier epithelial cells(ECs)represent the first line of defense and express pattern recognition receptors to recognize type-2 cell-mediated immune insults.An exaggerated abnormal barrier function or inadequate immune response may contribute to the pathophysiology of asthma.展开更多
Respiratory viruses are major human pathogens that cause approximately 200 million pneumonia cases annually and induce various comorbidities with chronic obstructive pulmonary disease(COPD),resulting in significant he...Respiratory viruses are major human pathogens that cause approximately 200 million pneumonia cases annually and induce various comorbidities with chronic obstructive pulmonary disease(COPD),resulting in significant health concerns and economic burdens.Clinical manifestations in respiratory viral infections and inflammations vary from asymptomatic,mild,to severe,depending on host immune cell responses to pathogens and interactions with airway epithelia.We critically review the activation,effector,and regulation of T cells in respiratory virus infections and chronic inflammations associated with COPD.Crosstalk among T cells,innate immune cells,and airway epithelial cells is discussed as essential parts of pathogenesis and protection in viral infections and COPD.We emphasize the specificity of peptide antigens and the functional heterogeneity of conventional CD4^(+) and CD8^(+) T cells to shed some light on potential cellular and molecular candidates for the future development of therapeutics and intervention against respiratory viral infections and inflammations.展开更多
Folic acid belongs to the group of water-soluble B vitamins and naturally exists in multiple forms in a wide variety of foods such as legumes,vegetables,liver,and milk(Iyer and Tomar,2009;Lyon et al.,2020).It is invol...Folic acid belongs to the group of water-soluble B vitamins and naturally exists in multiple forms in a wide variety of foods such as legumes,vegetables,liver,and milk(Iyer and Tomar,2009;Lyon et al.,2020).It is involved in many biochemical reactions critical for cell division,such as purine and pyrimidine biosynthesis,DNA/RNA biosynthesis,and amino acid metabolism(Iyer and Tomar,2009).Mammals cannot synthesize folic acid and thus they must acquire it from food.Although folic acid is ubiquitous in foods.展开更多
基金This project was supported by the National Natural Science Foundation of China (60572038)
文摘In practical multi-sensor information fusion systems, there exists uncertainty about the network structure, active state of sensors, and information itself （including fuzziness, randomness, incompleteness as well as roughness, etc）. Hence it requires investigating the problem of uncertain information fusion. Robust learning algorithm which adapts to complex environment and the fuzzy inference algorithm which disposes fuzzy information are explored to solve the problem. Based on the fusion technology of neural networks and fuzzy inference algorithm, a multi-sensor uncertain information fusion system is modeled. Also RANFIS learning algorithm and fusing weight synthesized inference algorithm are developed from the ANFIS algorithm according to the concept of robust neural networks. This fusion system mainly consists of RANFIS confidence estimator, fusing weight synthesized inference knowledge base and weighted fusion section. The simulation result demonstrates that the proposed fusion model and algorithm have the capability of uncertain information fusion, thus is obviously advantageous compared with the conventional Kalman weighted fusion algorithm.
基金supported by the National Natural Science Foundation of China (81788104, 81490531)the Ministry of Science and Technology of China (2015CB553406)CAMS Innovation Fund for Medical Sciences (2017-I2M-1-009)
文摘Plant-derived microRNAs have recently been reported to function in human blood and tissues. Controversy was immediately raised due to possible contamination and the lack of large sample sizes. Here, we report thousands of unique small RNAs derived from traditional Chinese medicine(TCM) herbs found in human blood cells and mouse lung tissues using a large-scale analysis.We extracted small RNAs from decoctions of 10 TCM plants(Ban Zhi Lian, Chai Hu, Chuan Xin Lian, Di Ding Zi Jin, Huang Qin, Jin Yin Hua, Lian Qiao, Pu Gong Ying, Xia Ku Cao, and Yu Xing Cao) and obtained millions of RNA sequences from each herb. We also obtained RNA-Seq data from the blood cells of humans who consumed herbal decoctions and from the lung tissues of mice administered RNAs from herbal decoctions via oral gavage. We identified thousands of unique small RNA sequences in human blood cells and mouse lung tissues. Some of these identified small RNAs from Chuan Xin Lian and Hong Jing Tian could be mapped to the genomes of the herbs, confirming their TCM plant origin. Small RNAs derived from herbs regulate mammalian gene expression in a sequence-specific manner, and thus are a superior novel class of herbal drug components that hold great potential as oral gene-targeted therapeutics, highlighting the important role of herbgenomics in their development.
基金supported by grants from the National Key Research and Development Program of China(Nos.2022YFF0710800 and 2018YFC1313600)Major International(Regional)Joint Research Project of China(No.81820108001)+3 种基金National Natural Science Foundation of China(Nos.81670029 and 82000038)Jiangsu Key Principal Investigator of Medicine(No.ZDRCA2016018)Project 333 for Cultivation of High-Level Talents(Leading Talents of the Young and Middle-Aged)(No.BRA2019078)Nanjing Key Project of Science and Technology(No.2019060002)
文摘To the Editor:Asthma is an abnormal chronic inflammatory disease characterized by the involvement of a complex network of cells.Barrier epithelial cells(ECs)represent the first line of defense and express pattern recognition receptors to recognize type-2 cell-mediated immune insults.An exaggerated abnormal barrier function or inadequate immune response may contribute to the pathophysiology of asthma.
基金supported by grants from the National Key Research and Development Program of China(No.2018YFC1313602)Major International(Regional)Joint Research Project(No.81820108001)+7 种基金National Natural Science Foundation of China(No.81670029)Jiangsu Key Principal Investigator of Medicine(No.ZDRCA2016018)Project 333 for Cultivation of Young and Middle-aged Leading Talents(No.BRA2019078)Jiangsu Key Program of Social Development(No.BE2015651)Nanjing Key Project of Science and Technology(No.2019060002)(to Linfu Zhou)the National Institute of Environmental Health Sciences(No.ES006096)Center for Environmental Genetics,National Institute of Allergy and Infectious Diseases(No.All 15358)American Lung Association(No.IA-629987)(to Shouxiong Huang).
文摘Respiratory viruses are major human pathogens that cause approximately 200 million pneumonia cases annually and induce various comorbidities with chronic obstructive pulmonary disease(COPD),resulting in significant health concerns and economic burdens.Clinical manifestations in respiratory viral infections and inflammations vary from asymptomatic,mild,to severe,depending on host immune cell responses to pathogens and interactions with airway epithelia.We critically review the activation,effector,and regulation of T cells in respiratory virus infections and chronic inflammations associated with COPD.Crosstalk among T cells,innate immune cells,and airway epithelial cells is discussed as essential parts of pathogenesis and protection in viral infections and COPD.We emphasize the specificity of peptide antigens and the functional heterogeneity of conventional CD4^(+) and CD8^(+) T cells to shed some light on potential cellular and molecular candidates for the future development of therapeutics and intervention against respiratory viral infections and inflammations.
基金This work was supported by the National Basic Research Program(973)of China(No.2016YFF0200503)the National Natural Science Foundation of China(No.21876146).
文摘Folic acid belongs to the group of water-soluble B vitamins and naturally exists in multiple forms in a wide variety of foods such as legumes,vegetables,liver,and milk(Iyer and Tomar,2009;Lyon et al.,2020).It is involved in many biochemical reactions critical for cell division,such as purine and pyrimidine biosynthesis,DNA/RNA biosynthesis,and amino acid metabolism(Iyer and Tomar,2009).Mammals cannot synthesize folic acid and thus they must acquire it from food.Although folic acid is ubiquitous in foods.
