目的观察柴胡疏肝散加味治疗脑卒中后焦虑障碍患者临床疗效及其对心率变异性(HRV)的影响。方法根据纳入、排除标准选取2015年9月-2017年2月于湖南中医药大学第二附属医院脑病门诊及住院部诊断为脑卒中后焦虑障碍的患者90例,随机分为中药...目的观察柴胡疏肝散加味治疗脑卒中后焦虑障碍患者临床疗效及其对心率变异性(HRV)的影响。方法根据纳入、排除标准选取2015年9月-2017年2月于湖南中医药大学第二附属医院脑病门诊及住院部诊断为脑卒中后焦虑障碍的患者90例,随机分为中药组(45例)和对照组(45例)。对照组口服氢溴酸西酞普兰片,中药组在对照组基础上加用柴胡疏肝散加味,两组均治疗6周。比较两组治疗前、治疗2周、治疗4周、治疗6周汉密尔顿焦虑量表(HAMA)、精神性焦虑因子、躯体性焦虑因子评分,治疗后临床疗效,治疗前、治疗6周HRV[时域指标:24 h内全部窦性心律(NN)R-R间期标准差(SDNN),24 h内每5 min NN R-R间期平均值标准差(SDANN),24 h内相邻R-R间期差值的均方根(RMSSD),24 h内相邻NN R-R间期差值>50 ms占百分比(PNN50)。频域指标:低频功率(LF),高频功率(HF),LF/HF]。结果治疗方法与时间在HAMA评分及其因子评分上存在交互作用(P<0.05);时间在HAMA评分及其因子评分上主效应显著(P<0.05);治疗方法在HAMA评分、精神性焦虑因子评分上主效应显著(P<0.05);治疗方法在躯体性焦虑因子评分上主效应不显著(P>0.05)。治疗4、6周中药组患者HAMA评分、精神性焦虑因子评分低于对照组(P<0.05)。治疗2、4、6周两组患者HAMA评分、精神性焦虑因子评分低于治疗前(P<0.05),治疗4、6周两组患者躯体性焦虑因子评分低于治疗前(P<0.05)。中药组患者临床疗效优于对照组(P<0.05)。治疗6周,中药组患者SDNN、SDANN、PNN50、HF高于对照组(P<0.05);治疗6周,中药组患者LF、LF/HF低于对照组(P<0.05)。结论柴胡疏肝散加味治疗脑卒中后焦虑障碍疗效确切,可改善HRV。展开更多
Objective:To observe the therapeutic efficacy of acupuncture plus Tai Ji Quan (Tai Chi) in recovering the neurological function and treating depression state in post-stroke depression patients,together with a 12-mo...Objective:To observe the therapeutic efficacy of acupuncture plus Tai Ji Quan (Tai Chi) in recovering the neurological function and treating depression state in post-stroke depression patients,together with a 12-month follow-up.Methods:A total of 105 eligible post-stroke depression patients were randomized into an acupuncture plus Tai Ji group (53 cases) and a control group (52 cases) based on their visiting sequence.The patients all received routine treatment and rehabilitation training for stroke.In addition,the control group was given oral administration of citalopram hydrobromide tablets,1 month as a course of treatment,for 3 courses in total.Meanwhile,the acupuncture plus Tai Ji group received acupuncture and practiced Tai Ji Quan,for 1 month and 12 months respectively.Before the intervention,after 1-month intervention and 12 months later,the National Institute of Health stroke scale (NIHSS),Barthel index (BI) and Hamilton depression rating scale (HAMD) were adopted for efficacy evaluation.Results:Prior to the intervention,there were no significant differences in HAMD,NIHSS and BI scores between the two groups (all P〉0.05);after 1-month intervention,there were significant between-group differences in NIHSS,BI and HAMD scores (P〈0.05 or P〈0.01);the 12-month follow-up revealed significant between-group differences in NIHSS,BI and HAMD scores (all P〈0.01).In the treatment of stroke,the total effective rate was 84.4% in the acupuncture plus Tai Ji group,significantly higher than 68.9% in the control group (P〈0.05);in the treatment of depression,the total effective rate was 86.7% in the acupuncture plus Tai Ji group,significantly higher than 77.8% in the control group (P〈0.05).Conclusion:Acupuncture plus Tai Ji Quan can produce a significant efficacy in improving the limb motor function and depression in post-stroke depression patients.展开更多
Objective:To investigate the effect of combining acupuncture and auricular point sticking on heart rate variability(HRV)in patients with post-stroke depression(PSD).Methods:A total of 80 cases with PSD were randomized...Objective:To investigate the effect of combining acupuncture and auricular point sticking on heart rate variability(HRV)in patients with post-stroke depression(PSD).Methods:A total of 80 cases with PSD were randomized into a treatment group and a control group.The control group was intervened by oral administration of paroxetine hydrochloride,whereas the treatment group received acupuncture plus auricular point sticking base on the same oral administration.The Hamilton depression rating scale(HAMD)and HRV were measured before and after treatment in both groups.Results:The individual and global scores of HAMD significantly dropped after 8 weeks of treatment in both groups(all P〈0.05).In the treatment group,anxiety/somatization factor,sleep disturbance,hopelessness factor,cognition factor and global score were significantly different from those in the control group(all P〈0.05).The 24 h standard deviation of all normal-to-normal R-R interval(SDNN),standard deviation of 5-minute average of normal R-R intervals(SDANN),root mean square of successive differences(RMSSD),percent of differences between adjacent normal R-R intervals 50 ms(PNN50)and high frequency(HF)were increased while low frequency(LF)and LF/HF decreased significantly after 8 weeks of treatment in both groups(P〈0.05).All items in the treatment group were significantly different from those in the control group(all P〈0.05).Conclusion:Combining acupuncture and auricular point sticking can enhance the conventional medical treatment for HRV in patients with PSD.展开更多
文摘目的观察柴胡疏肝散加味治疗脑卒中后焦虑障碍患者临床疗效及其对心率变异性(HRV)的影响。方法根据纳入、排除标准选取2015年9月-2017年2月于湖南中医药大学第二附属医院脑病门诊及住院部诊断为脑卒中后焦虑障碍的患者90例,随机分为中药组(45例)和对照组(45例)。对照组口服氢溴酸西酞普兰片,中药组在对照组基础上加用柴胡疏肝散加味,两组均治疗6周。比较两组治疗前、治疗2周、治疗4周、治疗6周汉密尔顿焦虑量表(HAMA)、精神性焦虑因子、躯体性焦虑因子评分,治疗后临床疗效,治疗前、治疗6周HRV[时域指标:24 h内全部窦性心律(NN)R-R间期标准差(SDNN),24 h内每5 min NN R-R间期平均值标准差(SDANN),24 h内相邻R-R间期差值的均方根(RMSSD),24 h内相邻NN R-R间期差值>50 ms占百分比(PNN50)。频域指标:低频功率(LF),高频功率(HF),LF/HF]。结果治疗方法与时间在HAMA评分及其因子评分上存在交互作用(P<0.05);时间在HAMA评分及其因子评分上主效应显著(P<0.05);治疗方法在HAMA评分、精神性焦虑因子评分上主效应显著(P<0.05);治疗方法在躯体性焦虑因子评分上主效应不显著(P>0.05)。治疗4、6周中药组患者HAMA评分、精神性焦虑因子评分低于对照组(P<0.05)。治疗2、4、6周两组患者HAMA评分、精神性焦虑因子评分低于治疗前(P<0.05),治疗4、6周两组患者躯体性焦虑因子评分低于治疗前(P<0.05)。中药组患者临床疗效优于对照组(P<0.05)。治疗6周,中药组患者SDNN、SDANN、PNN50、HF高于对照组(P<0.05);治疗6周,中药组患者LF、LF/HF低于对照组(P<0.05)。结论柴胡疏肝散加味治疗脑卒中后焦虑障碍疗效确切,可改善HRV。
文摘Objective:To observe the therapeutic efficacy of acupuncture plus Tai Ji Quan (Tai Chi) in recovering the neurological function and treating depression state in post-stroke depression patients,together with a 12-month follow-up.Methods:A total of 105 eligible post-stroke depression patients were randomized into an acupuncture plus Tai Ji group (53 cases) and a control group (52 cases) based on their visiting sequence.The patients all received routine treatment and rehabilitation training for stroke.In addition,the control group was given oral administration of citalopram hydrobromide tablets,1 month as a course of treatment,for 3 courses in total.Meanwhile,the acupuncture plus Tai Ji group received acupuncture and practiced Tai Ji Quan,for 1 month and 12 months respectively.Before the intervention,after 1-month intervention and 12 months later,the National Institute of Health stroke scale (NIHSS),Barthel index (BI) and Hamilton depression rating scale (HAMD) were adopted for efficacy evaluation.Results:Prior to the intervention,there were no significant differences in HAMD,NIHSS and BI scores between the two groups (all P〉0.05);after 1-month intervention,there were significant between-group differences in NIHSS,BI and HAMD scores (P〈0.05 or P〈0.01);the 12-month follow-up revealed significant between-group differences in NIHSS,BI and HAMD scores (all P〈0.01).In the treatment of stroke,the total effective rate was 84.4% in the acupuncture plus Tai Ji group,significantly higher than 68.9% in the control group (P〈0.05);in the treatment of depression,the total effective rate was 86.7% in the acupuncture plus Tai Ji group,significantly higher than 77.8% in the control group (P〈0.05).Conclusion:Acupuncture plus Tai Ji Quan can produce a significant efficacy in improving the limb motor function and depression in post-stroke depression patients.
文摘Objective:To investigate the effect of combining acupuncture and auricular point sticking on heart rate variability(HRV)in patients with post-stroke depression(PSD).Methods:A total of 80 cases with PSD were randomized into a treatment group and a control group.The control group was intervened by oral administration of paroxetine hydrochloride,whereas the treatment group received acupuncture plus auricular point sticking base on the same oral administration.The Hamilton depression rating scale(HAMD)and HRV were measured before and after treatment in both groups.Results:The individual and global scores of HAMD significantly dropped after 8 weeks of treatment in both groups(all P〈0.05).In the treatment group,anxiety/somatization factor,sleep disturbance,hopelessness factor,cognition factor and global score were significantly different from those in the control group(all P〈0.05).The 24 h standard deviation of all normal-to-normal R-R interval(SDNN),standard deviation of 5-minute average of normal R-R intervals(SDANN),root mean square of successive differences(RMSSD),percent of differences between adjacent normal R-R intervals 50 ms(PNN50)and high frequency(HF)were increased while low frequency(LF)and LF/HF decreased significantly after 8 weeks of treatment in both groups(P〈0.05).All items in the treatment group were significantly different from those in the control group(all P〈0.05).Conclusion:Combining acupuncture and auricular point sticking can enhance the conventional medical treatment for HRV in patients with PSD.