High crystallinity of TiOwas prepared by a modified alcohothermal method, in which titanium isopropoxide was used as the titania precursor, absolute ethanol as the reaction medium, and NHHCOas the raw materials for re...High crystallinity of TiOwas prepared by a modified alcohothermal method, in which titanium isopropoxide was used as the titania precursor, absolute ethanol as the reaction medium, and NHHCOas the raw materials for release of water, ammonia and carbon dioxides via in-situ decomposition. The X-ray powder diffraction（XRD） and transmission electron microscope（TEM） measurements showed that water and ammonia from the in-situ decomposition of NHHCOplayed an important role in conducting the size, shape, crystallinity and microstructure of TiO. The photoluminescence spectroscopy and photocurrent measurements indicated that enhanced crystallinity could hinder the recombination and promote the separation of electron-hole pairs in TiO, which contribute to the improvement of photocatalytic activity.Methyl orange photodegradation under UV light confirmed that high crystallinity of TiOdid present a high photocatalytic activity due to the effective separation of photoinduced charges.展开更多
The impaired differentiation ability of resident cells and disordered immune microenvironment in periodontitis pose a huge challenge for bone regeneration.Herein,we construct a piezoelectric hydrogel to rescue the imp...The impaired differentiation ability of resident cells and disordered immune microenvironment in periodontitis pose a huge challenge for bone regeneration.Herein,we construct a piezoelectric hydrogel to rescue the impaired osteogenic capability and rebuild the regenerative immune microenvironment through bioenergetic activation.Under local mechanical stress,the piezoelectric hydrogel generated piezopotential that initiates osteogenic differentiation of inflammatory periodontal ligament stem cells(PDLSCs)via modulating energy metabolism and promoting adenosine triphosphate(ATP)synthesis.Moreover,it also reshapes an anti-inflammatory and pro-regenerative niche through switching M1 macrophages to the M2 phenotype.The synergy of tilapia gelatin and piezoelectric stimulation enhances in situ regeneration in periodontal inflammatory defects of rats.These findings pave a new pathway for treating periodontitis and other immune-related bone defects through piezoelectric stimulation-enabled energy metabolism modulation and immunomodulation.展开更多
基金support of the National Natural Science Foundation of China(No.21163008,No.21366020)Jiangxi Collaborative Innovation Center for in vitro diagnostic reagents and instruments,the Natural Science Foundation of Jiangxi Province(No.20114BAB203009)+1 种基金Scientific & Technological Project of Jiangxi Science and Technology Normal University(No.2013ZDPYJD01,No.2015CXTD003)Graduate Innovation Foundation of Jiangxi Science and Technology Normal University(No.YC2014-X2)
文摘High crystallinity of TiOwas prepared by a modified alcohothermal method, in which titanium isopropoxide was used as the titania precursor, absolute ethanol as the reaction medium, and NHHCOas the raw materials for release of water, ammonia and carbon dioxides via in-situ decomposition. The X-ray powder diffraction（XRD） and transmission electron microscope（TEM） measurements showed that water and ammonia from the in-situ decomposition of NHHCOplayed an important role in conducting the size, shape, crystallinity and microstructure of TiO. The photoluminescence spectroscopy and photocurrent measurements indicated that enhanced crystallinity could hinder the recombination and promote the separation of electron-hole pairs in TiO, which contribute to the improvement of photocatalytic activity.Methyl orange photodegradation under UV light confirmed that high crystallinity of TiOdid present a high photocatalytic activity due to the effective separation of photoinduced charges.
基金grants from the National Natural Science Foundation of China(82271024,82072065,82202333)National Clinical Key Specialty(Z155080000004)+5 种基金Science and Technology Commission of Shanghai Municipality(22DZ2201300)Shanghai Pujiang Programme(23PJD050)Innovative Research Team of High-level Local Universities in Shanghai(SHSMU-ZLCX20212400)Research Discipline fund(KQXJXK2023)from Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine,and College of Stomatology,Shanghai Jiao Tong University,the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDA16021103)the Fundamental Research Funds for the Central Universities(E2EG6802X2,E2E46801)the National Youth Talent Support Program.
文摘The impaired differentiation ability of resident cells and disordered immune microenvironment in periodontitis pose a huge challenge for bone regeneration.Herein,we construct a piezoelectric hydrogel to rescue the impaired osteogenic capability and rebuild the regenerative immune microenvironment through bioenergetic activation.Under local mechanical stress,the piezoelectric hydrogel generated piezopotential that initiates osteogenic differentiation of inflammatory periodontal ligament stem cells(PDLSCs)via modulating energy metabolism and promoting adenosine triphosphate(ATP)synthesis.Moreover,it also reshapes an anti-inflammatory and pro-regenerative niche through switching M1 macrophages to the M2 phenotype.The synergy of tilapia gelatin and piezoelectric stimulation enhances in situ regeneration in periodontal inflammatory defects of rats.These findings pave a new pathway for treating periodontitis and other immune-related bone defects through piezoelectric stimulation-enabled energy metabolism modulation and immunomodulation.
基金supported by the National Natural Science Foundation of China(82072065 and 81471784)the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA16021103)+1 种基金the Fundamental Research Funds for the Central Universities(E2EG6802X2 and E2E46801)the National Youth Talent Support Program.
