Research on PM_(2.5) Concentration Model Based on MODIS Remote Sensing Retrieval

Aiming at the complex variation of haze and the influence of various factors,Xi'an is taken as the research area to study the qualitative and quantitative issues between aerosol optical depth(AOD)and haze before and after correction.Combining atmospheric water vapor content(PWV)and meteorological factor data,it is proposed to use"backward screening"method to carry out regression modeling and verification of the revised PM_(2.5) mass concentration,AOD,PWV and meteorological factors.The results show that the correlation between AOD and PM_(2.5) is significantly improved after vertical correction and humidity correction.From the model's decision coefficient R^(2) and the relative error of the estimated PM_(2.5) mass concentration,it can be seen that the estimation model of PM_(2.5) mass concentration based on multiple impact factors is better than the estimation model solely based on AOD.

Phase separation in cGAS-STING signaling

Biomolecular condensates formed by phase separation are widespread and play critical roles in many physiological and pathological processes.cGAS-STING signaling functions to detect aberrant DNA signals to initiate anti-infection defense and antitumor immunity.At the same time,cGAS-STING signaling must be carefully regulated to maintain immune homeostasis.Interestingly,exciting recent studies have reported that biomolecular phase separation exists and plays important roles in different steps of cGAS-STING signaling,including cGAS condensates,STING condensates,and IRF3 condensates.In addition,several intracellular and extracellular factors have been proposed to modulate the condensates in cGAS-STING signaling.These studies reveal novel activation and regulation mechanisms of cGAS-STING signaling and provide new opportunities for drug discovery.Here,we summarize recent advances in the phase separation of cGAS-STING signaling and the development of potential drugs targeting these innate immune condensates.