Recently,nanopores have been used in an essential technique for detecting single molecule with high sensitivity.The initial application of nanopores to DNA and RNA sequencing has been expanded to sensing proteins and ...Recently,nanopores have been used in an essential technique for detecting single molecule with high sensitivity.The initial application of nanopores to DNA and RNA sequencing has been expanded to sensing proteins and nanoparticles,including Bovine serum albumin,silica nanoparticles,polystyrene beads,and others.In our study,for the first time,a positively charged gold nanorod was investigated using a solid-state nanopore device.Various gold nanorods passed through the nanopore with different current blockages and duration times,providing a measurement of the nanorod diameter,length,and charge.Our findings indicate that nanopore sensing might be a new method for characterizing the size,shape,and charge of nanoparticles.展开更多
基金supported by the National Basic Research Program of China(2011CB707600)the National Natural Science Foundation of China(61071050)the National High Technology Research and Development Program of China(2012AA02A103)
文摘Recently,nanopores have been used in an essential technique for detecting single molecule with high sensitivity.The initial application of nanopores to DNA and RNA sequencing has been expanded to sensing proteins and nanoparticles,including Bovine serum albumin,silica nanoparticles,polystyrene beads,and others.In our study,for the first time,a positively charged gold nanorod was investigated using a solid-state nanopore device.Various gold nanorods passed through the nanopore with different current blockages and duration times,providing a measurement of the nanorod diameter,length,and charge.Our findings indicate that nanopore sensing might be a new method for characterizing the size,shape,and charge of nanoparticles.
